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Showing 1–3 of 3 results
Advanced filters: Author: Andrea Ruiz-Velasco Clear advanced filters

  • The mechanistic link between metabolic stress and associated cardiomyopathy is unknown. Here the authors show that high fat diet causes calpain-1-dependent degradation of ERK5 leading to mitochondrial dysfunction, suggesting the maintenance of cardiac ERK5 as a therapeutic approach for cardiomyopathy prevention and/or treatment.

    • Wei Liu
    • Andrea Ruiz-Velasco
    • Xin Wang
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-16

  • Modelling cardiomyocyte geometry reveals that mitochondrial–sarcoplasmic architecture enhances respiration by facilitating ion and lipid transfer for efficient cardiac metabolism.

    • Charlène Jouve
    • Andrea Ruiz-Velasco
    • Jean-Sébastien Hulot
    ResearchOpen Access
    Communications Biology
    Volume: 8, P: 1-14

  • Androgen receptor can promote tumour progression in desmoplastic small round cell tumour (DSRCT), an aggressive paediatric malignancy that predominantly affects young males. Here, the authors show that DSRCT is an AR-driven malignancy and sensitive to androgen deprivation therapy

    • Salah-Eddine Lamhamedi-Cherradi
    • Mayinuer Maitituoheti
    • Joseph A. Ludwig
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16