Nature Search

Identification and characterization of binders to a cryptic and functional pocket in KRAS

In this work, Beyer and colleagues have utilized display screening technologies to comprehensively chart RAS proteins “druggability” and in doing so unravel a targetable ligand-induced pocket in RAS opening unprecedented anti-RAS targeted opportunities.

Kim S. Beyer
Jessica Klein
Sauveur-Michel Maira
ResearchOpen Access02 Dec 2025
Nature Communications

Volume: 16, P: 1-15
Author Correction: Direct and selective pharmacological disruption of the YAP–TEAD interface by IAG933 inhibits Hippo-dependent and RAS–MAPK-altered cancers

Emilie A. Chapeau
Laurent Sansregret
Tobias Schmelzle
Amendments and CorrectionsOpen Access17 Jun 2024
Nature Cancer

Volume: 5, P: 1130
Biosynthesis of magnetic nanostructures in a foreign organism by transfer of bacterial magnetosome gene clusters

Magnetic nanoparticles are synthesized in a foreign host after gene transfer from magnetotactic bacteria.

Isabel Kolinko
Anna Lohße
Dirk Schüler
Research23 Feb 2014
Nature Nanotechnology

Volume: 9, P: 193-197
Direct and selective pharmacological disruption of the YAP–TEAD interface by IAG933 inhibits Hippo-dependent and RAS–MAPK-altered cancers

Chapeau et al. develop a nonallosteric inhibitor of the interaction between YAP and all four TEAD proteins. Treatment with the inhibitor, either as monotherapy or in combination with other treatment modalities, leads to induction of cell death in several in vivo cancer models.

Emilie A. Chapeau
Laurent Sansregret
Tobias Schmelzle
ResearchOpen Access02 Apr 2024
Nature Cancer

Volume: 5, P: 1102-1120
Isolated NIBPL missense mutations that cause Cornelia de Lange syndrome alter MAU2 interaction

Diana Braunholz
Melanie Hullings
Frank J Kaiser
Research21 Sept 2011
European Journal of Human Genetics

Volume: 20, P: 271-276
Chromosome organization by a conserved condensin-ParB system in the actinobacterium Corynebacterium glutamicum

The regulation of higher-order chromosome folding and segregation in bacteria is poorly understood. Here, Böhm et al. provide insights into the roles of DNA partitioning protein ParB and SMC condensin complexes in Corynebacterium glutamicum.

Kati Böhm
Giacomo Giacomelli
Marc Bramkamp
ResearchOpen Access20 Mar 2020
Nature Communications

Volume: 11, P: 1-17
Evidence for the sexual origin of heterokaryosis in arbuscular mycorrhizal fungi

Arbuscular mycorrhizal fungi have traditionally been considered an ancient asexual lineage. Comparative genomic analyses of Rhizophagus irregularis provides evidence of sexual reproduction in these fungi.

Jeanne Ropars
Kinga Sędzielewska Toro
Nicolas Corradi
Research21 Mar 2016
Nature Microbiology

Volume: 1, P: 1-9
Plastiphily is linked to generic virulence traits of important human pathogenic fungi

Compositional and phylogenetic differences between soil and plastisphere fungal communities indicate selection of pathogens in the plastisphere, according to metagenomic analyses and neutral community modelling applied to soil samples from Kenya.

Gerasimos Gkoutselis
Stephan Rohrbach
Gerhard Rambold
ResearchOpen Access25 Jan 2024
Communications Earth & Environment

Volume: 5, P: 1-18
Microplastics accumulate fungal pathogens in terrestrial ecosystems

Gerasimos Gkoutselis
Stephan Rohrbach
Gerhard Rambold
ResearchOpen Access15 Jul 2021
Scientific Reports

Volume: 11, P: 1-13
Ant-infecting Ophiocordyceps genomes reveal a high diversity of potential behavioral manipulation genes and a possible major role for enterotoxins

Charissa de Bekker
Robin A Ohm
David P. Hughes
ResearchOpen Access02 Oct 2017
Scientific Reports

Volume: 7, P: 1-13

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Identification and characterization of binders to a cryptic and functional pocket in KRAS

Author Correction: Direct and selective pharmacological disruption of the YAP–TEAD interface by IAG933 inhibits Hippo-dependent and RAS–MAPK-altered cancers

Biosynthesis of magnetic nanostructures in a foreign organism by transfer of bacterial magnetosome gene clusters

Direct and selective pharmacological disruption of the YAP–TEAD interface by IAG933 inhibits Hippo-dependent and RAS–MAPK-altered cancers

Isolated NIBPL missense mutations that cause Cornelia de Lange syndrome alter MAU2 interaction

Chromosome organization by a conserved condensin-ParB system in the actinobacterium Corynebacterium glutamicum

Evidence for the sexual origin of heterokaryosis in arbuscular mycorrhizal fungi

Plastiphily is linked to generic virulence traits of important human pathogenic fungi

Microplastics accumulate fungal pathogens in terrestrial ecosystems

Ant-infecting Ophiocordyceps genomes reveal a high diversity of potential behavioral manipulation genes and a possible major role for enterotoxins

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