Nature Search

Prevention of type 2 diabetes through prediabetes remission without weight loss

A post hoc analysis of a multicentre, randomised trial showed that prediabetes remission is possible without total weight loss—providing weight is distributed to subcutaneous deposits as opposed to visceral ones.

Arvid Sandforth
Elsa Vazquez Arreola
Reiner Jumpertz von Schwartzenberg
ResearchOpen Access29 Sept 2025
Nature Medicine

Volume: 31, P: 3330-3340
The interplay of central insulin and menstrual cycle on functional brain networks and neural food cue reactivity in women

Central insulin effects on brain networks and food cue reactivity in the hippocampus and striatum vary dynamically across the menstrual cycle in premenopausal women, with estradiol and progesterone predicting these changes.

Julia Hummel
Sixiu Zhao
Stephanie Kullmann
ResearchOpen Access06 Jan 2026
Communications Biology

Volume: 9, P: 1-12
Elevated circulating follistatin associates with an increased risk of type 2 diabetes

Follistatin promotes in type 2 diabetes (T2D) pathogenesis in model animals and is elevated in patients with T2D. Here the authors report that plasma follistatin associates with increased risk of incident T2D in two longitudinal cohorts, and show that follistatin regulates insulin-induced suppression lipolysis in cultured human adipocytes.

Chuanyan Wu
Yan Borné
Yang De Marinis
ResearchOpen Access10 Nov 2021
Nature Communications

Volume: 12, P: 1-10
A future without needles: non-invasive glucose measurements in patients with diabetes

Optical measurements through the skin are challenging because they usually represent averages across the various layers of skin that are illuminated. A study in Nature Metabolism uses a depth-selective variant of Raman spectroscopy to probe glucose levels specifically in the skin vasculature, and thereby achieves improved glucose sensing in humans.

Andreas L. Birkenfeld
Vasilis Ntziachristos
News & Views05 Feb 2025
Nature Metabolism

Volume: 7, P: 247-248
Author Correction: Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1-dependent manner

Utpal B. Pajvani
Carrie J. Shawber
Domenico Accili
Amendments and Corrections01 Dec 2023
Nature Medicine

Volume: 30, P: 604
No modulation of postprandial metabolism by transcutaneous auricular vagus nerve stimulation: a cross-over study in 15 healthy men

Andreas Vosseler
Dongxing Zhao
Martin Heni
ResearchOpen Access24 Nov 2020
Scientific Reports

Volume: 10, P: 1-9
Identification and characterization of two functional variants in the human longevity gene FOXO3

FOXO3 is one of the few established longevity genes. Here, the authors fine-map the FOXO3-longevity association to two intronic SNPs and, using luciferase assays and EMSAs, show that these SNPs affect binding of transcription factors CTCF and SRF and associate with FOXO3 expression.

Friederike Flachsbart
Janina Dose
Almut Nebel
ResearchOpen Access12 Dec 2017
Nature Communications

Volume: 8, P: 1-12
Reduced insulin clearance is linked to subclinical atherosclerosis in individuals at risk for type 2 diabetes mellitus

Elko Randrianarisoa
Angela Lehn-Stefan
Martin Heni
ResearchOpen Access31 Dec 2020
Scientific Reports

Volume: 10, P: 1-8
A short-term, high-caloric diet has prolonged effects on brain insulin action in men

Short-term overeating with calorie-rich snacks is shown to disrupt insulin action in the brain of men, which outlasted the time-frame of overeating.

Stephanie Kullmann
Lore Wagner
Andreas L. Birkenfeld
ResearchOpen Access21 Feb 2025
Nature Metabolism

Volume: 7, P: 469-477
Prediabetes remission for type 2 diabetes mellitus prevention

Current guidelines for the delay and prevention of type 2 diabetes mellitus recommend for people with prediabetes to lose at least 7% of their body weight. Here, we advocate to use glycaemic remission as a goal of prevention in people with prediabetes and those who are at high risk for type 2 diabetes mellitus.

Andreas L. Birkenfeld
Viswanathan Mohan
Comments & Opinion28 May 2024
Nature Reviews Endocrinology

Volume: 20, P: 441-442
Enhanced maximum intensity projection (eMIP) for improving the fidelity of optoacoustic images

Manuel Gehmeyr
María Begoña Rojas López
Vasilis Ntziachristos
ResearchOpen Access06 Oct 2025
npj Imaging

Volume: 3, P: 1-13
Brain insulin action on peripheral insulin sensitivity in women depends on menstrual cycle phase

In young women, brain insulin action enhances peripheral insulin sensitivity, but only during the follicular phase of the menstrual cycle. This effect is absent in the luteal phase, possibly due to hypothalamic insulin resistance.

Julia Hummel
Charlotte Benkendorff
Martin Heni
ResearchOpen Access21 Sept 2023
Nature Metabolism

Volume: 5, P: 1475-1482
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Slow deep breathing modulates cardiac vagal activity but does not affect peripheral glucose metabolism in healthy men

Andreas Vosseler
Dongxing Zhao
Martin Heni
ResearchOpen Access13 Oct 2021
Scientific Reports

Volume: 11, P: 1-8
Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1-dependent manner

Notch, a molecule widely known for its role in development and cancer, regulates hepatic glucose metabolism by offsetting excessive glucose production. Given that a series of Notch antagonists are in clinical trials against cancer, they could also be useful against type 2 diabetes.

Utpal B Pajvani
Carrie J Shawber
Domenico Accili
Research31 Jul 2011
Nature Medicine

Volume: 17, P: 961-967
Pathophysiology-based subphenotyping of individuals at elevated risk for type 2 diabetes

Clustering of patients with prediabetes using simple clinical features reveals six distinct groups with differing risk of developing type 2 diabetes and its associated complications.

Robert Wagner
Martin Heni
Andreas Fritsche
Research04 Jan 2021
Nature Medicine

Volume: 27, P: 49-57
Retinol saturase coordinates liver metabolism by regulating ChREBP activity

Fatty liver is one of the major features of metabolic syndrome and its development is associated with deregulation of systemic lipid and glucose homeostasis. Here Heidenreich et al. show that retinol saturase is implicated in hepatic lipid metabolism by regulating the activity of the transcription factor ChREBP.

Steffi Heidenreich
Nicole Witte
Michael Schupp
ResearchOpen Access30 Aug 2017
Nature Communications

Volume: 8, P: 1-10
Dapagliflozin effects on haematocrit, red blood cell count and reticulocytes in insulin-treated patients with type 2 diabetes

Jens Aberle
Markus Menzen
Andreas L. Birkenfeld
ResearchOpen Access28 Dec 2020
Scientific Reports

Volume: 10, P: 1-8
Regulation of body weight and energy homeostasis by neuronal cell adhesion molecule 1

The precise mechanisms that cause human obesity remain unknown. Here the authors illustrate how increased expression of Cadm1, a mediator of synapse assembly, is relevant to weight gain. Reduction of Cadm1 in multiple brain regions promoted weight loss, and these observations provide insight into the neuronal pathways contributing to obesity.

Thomas Rathjen
Xin Yan
Matthew N Poy
Research19 Jun 2017
Nature Neuroscience

Volume: 20, P: 1096-1103
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Free fatty acids, glicentin and glucose-dependent insulinotropic polypeptide as potential major determinants of fasting substrate oxidation

Julia Hummel
Louise Fritsche
Martin Heni
ResearchOpen Access17 Aug 2021
Scientific Reports

Volume: 11, P: 1-9
Deletion of the diabetes candidate gene Slc16a13 in mice attenuates diet-induced ectopic lipid accumulation and insulin resistance

Schumann et al. demonstrate that the loss of a lactate transporter Slc16a13 increases mitochondrial respiration in the liver, which reduces hepatic lipid accumulation while increasing hepatic insulin sensitivity in mice fed a high-fat diet. This study suggests SLC16A13 as a potential target for the treatment of type 2 diabetes and non-alcoholic fatty liver disease.

Tina Schumann
Jörg König
Andreas L. Birkenfeld
ResearchOpen Access01 Jul 2021
Communications Biology

Volume: 4, P: 1-17
Obesity and impaired metabolic health in patients with COVID-19

Preliminary data suggest that people with obesity are at increased risk of severe COVID-19. However, as data on metabolic parameters (such as BMI and levels of glucose and insulin) in patients with COVID-19 are scarce, increased reporting is needed to improve our understanding of COVID-19 and the care of affected patients.

Norbert Stefan
Andreas L. Birkenfeld
David S. Ludwig
Comments & Opinion23 Apr 2020
Nature Reviews Endocrinology

Volume: 16, P: 341-342
Acute and long-term exercise adaptation of adipose tissue and skeletal muscle in humans: a matched transcriptomics approach after 8-week training-intervention

Transcriptional alterations demonstrate that adipose tissue responded to exercise completely distinct from skeletal muscle in the same human subjects. Adipose tissue showed acute and repeated reduction in transcripts of lipid uptake, synthesis and storage. The data also suggest the restoration of a healthier circadian rhythm in adipose tissue of subjects with obesity after regularly performed exercise. The interconnection of circadian rhythm with lipid metabolism possibly contributes to improved metabolic health and prevention of diabetes.

Simon I. Dreher
Martin Irmler
Anja Moller
ResearchOpen Access11 Feb 2023
International Journal of Obesity

Volume: 47, P: 313-324
Metabolic implications of pancreatic fat accumulation

There is growing evidence that fat accumulation in the pancreas can have consequences for metabolic health. This Review discusses the methods for detecting pancreatic fat and the potential causes and pathogenic consequences of pancreatic fat accumulation.

Robert Wagner
Sabine S. Eckstein
Martin Heni
Reviews20 Oct 2021
Nature Reviews Endocrinology

Volume: 18, P: 43-54
Consequences of the COVID-19 pandemic for patients with metabolic diseases

The COVID-19 pandemic has stretched healthcare resources and caused severe knock-on effects on patients with metabolic diseases worldwide. We encourage clinicians and patient-interest groups in the field of diabetes and metabolism to raise their voices to ensure adequate care and admission of patients.

Stefan R. Bornstein
Francesco Rubino
Geltrude Mingrone
Comments & Opinion25 Feb 2021
Nature Metabolism

Volume: 3, P: 289-292
The anorexigenic peptide neurotensin relates to insulin sensitivity in obese patients after BPD or RYGB metabolic surgery

Christian von Loeffelholz
Lidia Castagneto Gissey
Andreas L. Birkenfeld
Research24 May 2018
International Journal of Obesity

Volume: 42, P: 2057-2061
Sex differences in central insulin action: Effect of intranasal insulin on neural food cue reactivity in adults with normal weight and overweight

Lore Wagner
Ralf Veit
Stephanie Kullmann
ResearchOpen Access17 Jun 2022
International Journal of Obesity

Volume: 46, P: 1662-1670
New insight into the mechanisms of ectopic fat deposition improvement after bariatric surgery

Giulia Angelini
Lidia Castagneto Gissey
Giovanni Casella
ResearchOpen Access21 Nov 2019
Scientific Reports

Volume: 9, P: 1-15
Exposure to gestational diabetes mellitus in utero impacts hippocampal functional connectivity in response to food cues in children

Sixiu Zhao
Lorenzo Semeia
Stephanie Kullmann
ResearchOpen Access28 Aug 2024
International Journal of Obesity

Volume: 48, P: 1728-1734
Network-targeted transcranial direct current stimulation of the hypothalamus appetite-control network: a feasibility study

Theresa Ester-Nacke
Katharina Berti
Stephanie Kullmann
ResearchOpen Access18 May 2024
Scientific Reports

Volume: 14, P: 1-11
Global pandemics interconnected — obesity, impaired metabolic health and COVID-19

This Review highlights how obesity and impaired metabolic health increase complications and mortality in coronavirus disease 2019 (COVID-19) and summarizes the consequences of infection with severe acute respiratory syndrome coronavirus 2 for organ function. In addition, there is a discussion on the implications of the COVID-19 pandemic for the obesity pandemic.

Norbert Stefan
Andreas L. Birkenfeld
Matthias B. Schulze
Reviews21 Jan 2021
Nature Reviews Endocrinology

Volume: 17, P: 135-149
The Journey to a FAIR CORE DATA SET for Diabetes Research in Germany

Esther Thea Inau
Angela Dedié
Dagmar Waltemath
ResearchOpen Access21 Oct 2024
Scientific Data

Volume: 11, P: 1-13
Publisher Correction: New insight into the mechanisms of ectopic fat deposition improvement after bariatric surgery

Giulia Angelini
Lidia Castagneto Gissey
Giovanni Casella
Amendments and CorrectionsOpen Access12 Feb 2020
Scientific Reports

Volume: 10, P: 1
Endoplasmic reticulum stress and the unfolded protein response in skeletal muscle of subjects suffering from peritoneal sepsis

Uta Barbara Metzing
Christian von Loeffelholz
Paul Horn
ResearchOpen Access11 Jan 2022
Scientific Reports

Volume: 12, P: 1-11
Effects of adrenergic-stimulated lipolysis and cytokine production on in vitro mouse adipose tissue–islet interactions

Morgana Barroso Oquendo
Estela Lorza-Gil
Felicia Gerst
ResearchOpen Access22 Sept 2022
Scientific Reports

Volume: 12, P: 1-12
IK_Ca channels control breast cancer metabolism including AMPK-driven autophagy

Dominic Gross
Helmut Bischof
Robert Lukowski
ResearchOpen Access27 Oct 2022
Cell Death & Disease

Volume: 13, P: 1-14
FFA2-, but not FFA3-agonists inhibit GSIS of human pseudoislets: a comparative study with mouse islets and rat INS-1E cells

Estela Lorza-Gil
Gabriele Kaiser
Susanne Ullrich
ResearchOpen Access05 Oct 2020
Scientific Reports

Volume: 10, P: 1-11
Publisher Correction: Deletion of the diabetes candidate gene Slc16a13 in mice attenuates diet-induced ectopic lipid accumulation and insulin resistance

Tina Schumann
Jörg König
Andreas L. Birkenfeld
Amendments and CorrectionsOpen Access14 Jul 2021
Communications Biology

Volume: 4, P: 1
Extra-viral DNA in adeno-associated viral vector preparations induces TLR9-dependent innate immune responses in human plasmacytoid dendritic cells

Kirsten Bucher
Eduardo Rodríguez-Bocanegra
M. Dominik Fischer
ResearchOpen Access02 Feb 2023
Scientific Reports

Volume: 13, P: 1-13
Renal effects of the serine protease inhibitor aprotinin in healthy conscious mice

Stefan Wörner
Bernhard N. Bohnert
Ferruh Artunc
ResearchOpen Access23 Mar 2021
Acta Pharmacologica Sinica

Volume: 43, P: 111-120
Analysis of naturally occurring mutations in the human uptake transporter NaCT important for bone and brain development and energy metabolism

Stefan Selch
Anja Chafai
Jörg König
ResearchOpen Access27 Jul 2018
Scientific Reports

Volume: 8, P: 1-12
Development and validation of a reinforcement learning algorithm to dynamically optimize mechanical ventilation in critical care

Arne Peine
Ahmed Hallawa
Lukas Martin
ResearchOpen Access19 Feb 2021
npj Digital Medicine

Volume: 4, P: 1-12
Pharmacogenomics in type 2 diabetes: oral antidiabetic drugs

M A Daniels
C Kan
A L Birkenfeld
Reviews19 Jul 2016
The Pharmacogenomics Journal

Volume: 16, P: 399-410

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