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Showing 1–7 of 7 results
Advanced filters: Author: Andrew Callan-Jones Clear advanced filters

  • The inverted-BAR domain protein IRSp53 associates with the inner leaflet of tubular membranes such as filopodia. Here, Prévostet al. demonstrate that the I-BAR domain of IRSp53 senses negative membrane curvature, and undergoes phase separation which may aid its clustering upon filopodia generation.

    • Coline Prévost
    • Hongxia Zhao
    • Patricia Bassereau
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-11

  • Within three-dimensional environments, leukocytes can migrate even in the complete absence of adhesive forces using the topographical features of the substrate to propel themselves.

    • Anne Reversat
    • Florian Gaertner
    • Michael Sixt
    Research
    Nature
    Volume: 582, P: 582-585

  • Mechanical load-sharing enables the long-range cooperative uptake of apoptotic cells by multiple epithelial cells; and clearance of these apoptotic cells facilitates error correction, which is necessary for developmental robustness and survival of the embryo.

    • Esteban Hoijman
    • Hanna-Maria Häkkinen
    • Verena Ruprecht
    Research
    Nature
    Volume: 590, P: 618-623

  • Adherent cells actively probe the rigidity of their substrates. Guptaet al. show that actin cytoskeleton rheology transitions from fluid to solid with increased substrate stiffness along with an isotropic to nematic ordering, implicating the remodelling of the whole actin network in rigidity sensing.

    • Mukund Gupta
    • Bibhu Ranjan Sarangi
    • Benoît Ladoux
    Research
    Nature Communications
    Volume: 6, P: 1-9

  • Membrane curvature induces sorting of GPCRs within live-cell-membrane protrusions, and the curvature-dependent sorting is affected by agonist binding. Thermodynamic modeling suggests that this is due to an energetic drive to match receptor shape and elasticity to membrane curvature.

    • Kadla R Rosholm
    • Natascha Leijnse
    • Dimitrios Stamou
    Research
    Nature Chemical Biology
    Volume: 13, P: 724-729