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Two-qubit operations exceeding 99% fidelity have been demonstrated by silicon devices made with standard semiconductor tooling in a 300-mm foundry environment.

Silicon-based spin qubits are promising candidates for a scalable quantum computer. Here the authors demonstrate the violation of Bell’s inequality in gate-defined quantum dots in silicon, marking a significant advancement that showcases the maturity of this platform.

The coherent operation of individual ³¹P electron and nuclear spin qubits in a ²⁸Si substrate shows new benchmark decoherence times and provides essential information on the dechorence mechanism.

A materials platform using tantalum as a base layer and silicon as the substrate to construct superconducting qubits enables device performance improvements such as millisecond lifetimes and coherence times, as well as high time-averaged quality factors.

Initialization and operation of spin qubits in silicon above 1 K reach fidelities sufficient for fault-tolerant operations at these temperatures.

A single electron spin in silicon is dressed by a microwave field to create a new qubit with tangible advantages for quantum computation and nanoscale research.

Superradiance is usually driven by light-mediated couplings, leaving the role of direct emitter interactions unclear. Now, it is shown that dipole–dipole interactions in diamond spins drive self-induced pulsed and continuous superradiant masing.

Global control of a qubits using a single microwave field is a promising strategy for scalable quantum computing. Here the authors demonstrate individual addressability vial local electrodes and two-qubit gates in an array of Si quantum dot spin qubits dressed by a global microwave field and driven on-resonance.

The coherent manipulation of an individual electron spin qubit bound to a single phosphorus donor atom in natural silicon provides an excellent platform on which to build a scalable quantum computer.

Donors spins in silicon are coherent, high-performance qubits, but scale-up has been challenging. Here the authors present the first experimental demonstration of exchange-based, entangling two qubit gates between electrons bound to ³¹P donors in Si.

As the performance of silicon-based qubits has improved, there has been increasing focus on developing designs that are compatible with industrial processes. Here, Jock et al. exploit spin-orbit coupling to demonstrate full, all-electrical control of a metal-oxide-semiconductor electron spin qubit.

High-performance all-electrical control is a prerequisite for scalable silicon quantum computing. The switchable interaction between spins and orbital motion of electrons in silicon quantum dots now enables the electrical control of a spin qubit with high fidelity and speed, without the need for integrating a micromagnet.

Covalency in actinide–­ligand bonding is poorly understood compared to that in other parts of the periodic table due to the lack of experimental data. Here, pulsed electron paramagnetic resonance methods are used to directly measure the electron spin densities at coordinated ligands in molecular thorium and uranium complexes.

LRFN2 in cone photoreceptors is vital for building the OFF pathway. Here authors report this cell-adhesion molecule stabilizes contacts with OFF bipolar cells, clusters their ionotropic receptors, and is required for negative-contrast vision and predator-detection behaviors.

For solid-state qubits, the material environment hosts sources of errors that vary in time and space. This systematic analysis of errors affecting high-fidelity two-qubit gates in silicon can inform the design of large-scale quantum computers.

CMOS-based circuits can be integrated with silicon-based spin qubits and can be controlled at milli-kelvin temperatures, which can potentially help scale up these systems.

A large nuclear spin has been successfully placed in a Schrödinger cat state, a superposition of its two most widely separated spin coherent states. This can be used as an error-correctable qubit.

Scalable quantum information processing requires controllable high-coherence qubits. Here, the authors present superconducting flux qubits with broad frequency tunability, strong anharmonicity and high reproducibility, identifying photon shot noise as the main source of dephasing for further improvements.

Using a cryogenic 300-mm wafer prober, a new approach for the testing of hundreds of industry-manufactured spin qubit devices at 1.6 K provides high-volume data on performance, allowing optimization of the complementary metal–oxide–semiconductor (CMOS)-compatible fabrication process.

Nuclear spins are excellent qubits, but long-range interactions are difficult to establish. Here, the authors couple a ²⁹Si nuclear spin to electrons in a lithographically defined quantum dot and show initialization, readout and entanglement with the electron spin. The ²⁹Si retains its coherence under electron transfer between quantum dots.

Starble, Sun, and colleagues identify an epigenetic priming mechanism that promotes oncogene amplification in acquired resistance to tyrosine kinase inhibitors and establishes a role of METTL7A in this process.

Myeloid-specific mechanotransduction ablation downregulates pro-fibrotic fibroblast transcriptional profiles to reduce scar formation in human cells

Bidirectional, cyanobacteriochrome-based light-inducible dimers (BICYCL)s enable optogenetic control of protein–protein interactions with green and red light, allowing multiplexing with existing blue light-controlled tools.

A genome-wide association study including over 76,000 individuals with schizophrenia and over 243,000 control individuals identifies common variant associations at 287 genomic loci, and further fine-mapping analyses highlight the importance of genes involved in synaptic processes.

This study used fine-mapping to analyze genetic regions associated with bipolar disorder, identifying specific risk genes and providing new insights into the biology of the condition that may guide future research and treatment approaches.

Using multi-ancestry genome-wide association study and fine-mapping, 298 loci and 36 credible genes are identified in the aetiology of bipolar disorder.

Structural and morphological control of crystalline nanoparticles is crucial in heterogeneous catalysis. Applying DFT-assisted solid-state NMR spectroscopy, we determine the surface crystal and electronic structure of Ni₂P nanoparticles, unveiling NMR nanocrystallography as an emerging tool in facet-engineered nanocatalysts.

Clinical management of pancreatic cancer remains challenging. Here, the authors suggest SMARCD3 as a potential epigenetic dependency establishing the metabolic landscape in aggressive pancreatic cancer cells and as a potential therapeutic target in pancreatic cancer.

Proteins separated on sodium dodecyl sulphate-polyacrylamide gels can be detected in subpicogram quantities by radioactivation of silver-treated protein molecules.

Genetic, structural and biochemical analysis identifies GacH as a glycerol phosphate transferase that modifies N-acetylglucosamine components of group A carbohydrates (GAC) in streptococcal cell walls.

Humans tend to adopt one of a limited number of different bacterial community structures in the gut, known as enterotypes. Moeller et al.now show that these microbial fingerprints are conserved in chimpanzees, and that individuals can switch between enterotypes over periods of several years.

Glycan synthesis is regulated by the concerted activity of many genes. Here, Tsui et al. present a generalizable strategy utilizing CRISPR screens and lectin microarrays to identify and characterize regulators of glycosylation.

Viscous Dirac fluid flow in room-temperature graphene is imaged using quantum diamond magnetometry, revealing a parabolic Poiseuille profile for electron flow in a high-mobility graphene channel near the charge-neutrality point.

EchoNext, a deep learning model for electrocardiograms trained and validated in diverse health systems, successfully detects many forms of structural heart disease, supporting the potential of artificial intelligence to expand access to heart disease screening at scale.

Identifying therapeutic targets in rare cancers is challenging due to the lack of relevant pre-clinical models. Here, the authors generate a cancer cell line from a paediatric patient with a rare undifferentiated sarcoma and through functional genomics and chemical screens identified CDK4 and XPO1 as potential therapeutic targets in this cancer.

Stratified medicine promises to tailor treatment for individual patients, however it remains a major challenge to leverage genetic risk data to aid patient stratification. Here the authors introduce an approach to stratify individuals based on the aggregated impact of their genetic risk factor profiles on tissue-specific gene expression levels, and highlight its ability to identify biologically meaningful and clinically actionable patient subgroups, supporting the notion of different patient ‘biotypes’ characterized by partially distinct disease mechanisms.