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Showing 1–6 of 6 results
Advanced filters: Author: Andrew Olander Clear advanced filters

  • Here, the authors investigate the proteome trajectory of human iPSCs differentiating into hepatic stellate cells (diHSCs) and identify RORA as a key transcription factor that governs metabolic reprogramming essential for diHSCs’ commitment, identity, and quiescent phenotype.

    • Raquel A. Martínez García de la Torre
    • Julia Vallverdú
    • Pau Sancho-Bru
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19

  • An orally bioavailable small-molecule active-site inhibitor of the phosphatases PTPN2 and PTPN1, ABBV-CLS-484, demonstrates immunotherapeutic efficacy in mouse models of cancer resistant to PD-1 blockade.

    • Christina K. Baumgartner
    • Hakimeh Ebrahimi-Nik
    • Robert T. Manguso
    ResearchOpen Access
    Nature
    Volume: 622, P: 850-862

  • A challenge for testing mechanisms of past climate change is the precise correlation of palaeoclimate records. Here, through climate modelling and the alignment of terrestrial, ice and marine 14C and 10Be records, the authors show that Southern Ocean freshwater hosing can trigger global change.

    • Chris S. M. Turney
    • Richard T. Jones
    • Alan Cooper
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-9

  • Rich evidence of the potential co-benefits and trade-offs of natural climate solutions is available but remains poorly understood. Assessing the literature with machine learning methods, this study maps and analyses the growing evidence of trade-offs in natural climate solutions globally.

    • Charlotte H. Chang
    • James T. Erbaugh
    • Yuta J. Masuda
    Research
    Nature Sustainability
    Volume: 8, P: 75-85

  • Evidence-based approaches to sustainability challenges must draw on knowledge from the environment, development and health communities. To be practicable, this requires an approach to evidence that is broader and less hierarchical than the standards often applied within disciplines.

    • Edward T. Game
    • Heather Tallis
    • William J. Sutherland
    Comments & Opinion
    Nature Sustainability
    Volume: 1, P: 452-454