Nature Search

Neuroanatomical dimensions in major depression linked to cognition, adverse life events, self-harm, metabolomics and genetics

Xiao, Woodham, Cui, et al. apply machine learning to brain MRI data from major depression and the UK Biobank. They identify two neuroanatomical dimensions, one linked to preserved brain structure and healthier outcomes, and the other to reduced volumes, impaired cognition, self-harm, and adverse metabolic and genetic profiles.

Wenyi Xiao
Rachel D. Woodham
Cynthia H. Y. Fu
ResearchOpen Access15 Nov 2025
Communications Medicine

Volume: 5, P: 1-16
In vivo detection of antigen-specific CD8⁺ T cells by immuno-positron emission tomography

Antigen-specific CD8⁺ T cells can be imaged by immunoPET with the help of synTacs, MHC-based tools that bind to relevant T-cell receptors.

Andrew W. Woodham
Stad H. Zeigler
Hidde L. Ploegh
Research14 Sept 2020
Nature Methods

Volume: 17, P: 1025-1032
Improved GPCR ligands from nanobody tethering

Antibodies conjugated to bioactive compounds can allow targeted delivery of therapeutics. Here the authors present a strategy for fusing nanobodies to suboptimal GPCR peptide ligands to potently and selectively activate receptors.

Ross W. Cheloha
Fabian A. Fischer
Hidde L. Ploegh
ResearchOpen Access29 Apr 2020
Nature Communications

Volume: 11, P: 1-11
Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency

Tait and colleagues show that caspase-independent cell death induced by mitochondrial permeabilization stimulates NF-κB activity through downregulation of inhibitor of apoptosis, and enhances anti-tumour effects.

Evangelos Giampazolias
Barbara Zunino
Stephen W. G. Tait
Research28 Aug 2017
Nature Cell Biology

Volume: 19, P: 1116-1129
Mapping B-cell responses to Salmonella enterica serovars Typhimurium and Enteritidis in chickens for the discrimination of infected from vaccinated animals

Ibrahim A. Naqid
Jonathan P. Owen
Kevin C. Gough
ResearchOpen Access11 Aug 2016
Scientific Reports

Volume: 6, P: 1-7
The variability and seasonality of the environmental reservoir of Mycobacterium bovis shed by wild European badgers

Hayley C. King
Andrew Murphy
Elizabeth M. Wellington
ResearchOpen Access06 Aug 2015
Scientific Reports

Volume: 5, P: 1-7
Extracellular Protein Fibulin-7 and Its C-Terminal Fragment Have In Vivo Antiangiogenic Activity

Tomoko Ikeuchi
Susana de Vega
Yoshihiko Yamada
ResearchOpen Access05 Dec 2018
Scientific Reports

Volume: 8, P: 1-11
An RNA nanoparticle vaccine against Zika virus elicits antibody and CD8+ T cell responses in a mouse model

Jasdave S. Chahal
Tao Fang
Hidde L. Ploegh
ResearchOpen Access21 Mar 2017
Scientific Reports

Volume: 7, P: 1-9
Assessing effects from four years of industry-led badger culling in England on the incidence of bovine tuberculosis in cattle, 2013–2017

Sara H. Downs
Alison Prosser
Jessica E. Parry
ResearchOpen Access11 Oct 2019
Scientific Reports

Volume: 9, P: 1-14
Automating the assessment of biofouling in images using expert agreement as a gold standard

Evelyn J. Mannix
Susan Wei
Andrew P. Robinson
ResearchOpen Access02 Feb 2021
Scientific Reports

Volume: 11, P: 1-10
Detection and characterisation of multiple herpesviruses in free-living Western European hedgehogs (Erinaceus europaeus)

Helle B. Hydeskov
Akbar Dastjerdi
Becki Lawson
ResearchOpen Access17 Sept 2018
Scientific Reports

Volume: 8, P: 1-8
Mapping polyclonal antibody responses to bacterial infection using next generation phage display

Ibrahim A. Naqid
Jonathan P. Owen
Kevin C. Gough
ResearchOpen Access13 Apr 2016
Scientific Reports

Volume: 6, P: 1-11
Forensic microbiology reveals that Neisseria animaloris infections in harbour porpoises follow traumatic injuries by grey seals

Geoffrey Foster
Adrian M. Whatmore
Lonneke L. IJsseldijk
ResearchOpen Access11 Oct 2019
Scientific Reports

Volume: 9, P: 1-8

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Neuroanatomical dimensions in major depression linked to cognition, adverse life events, self-harm, metabolomics and genetics

In vivo detection of antigen-specific CD8⁺ T cells by immuno-positron emission tomography

Improved GPCR ligands from nanobody tethering

Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency

Mapping B-cell responses to Salmonella enterica serovars Typhimurium and Enteritidis in chickens for the discrimination of infected from vaccinated animals

The variability and seasonality of the environmental reservoir of Mycobacterium bovis shed by wild European badgers

Extracellular Protein Fibulin-7 and Its C-Terminal Fragment Have In Vivo Antiangiogenic Activity

An RNA nanoparticle vaccine against Zika virus elicits antibody and CD8+ T cell responses in a mouse model

Assessing effects from four years of industry-led badger culling in England on the incidence of bovine tuberculosis in cattle, 2013–2017

Automating the assessment of biofouling in images using expert agreement as a gold standard

Detection and characterisation of multiple herpesviruses in free-living Western European hedgehogs (Erinaceus europaeus)

Mapping polyclonal antibody responses to bacterial infection using next generation phage display

Forensic microbiology reveals that Neisseria animaloris infections in harbour porpoises follow traumatic injuries by grey seals

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