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Showing 1–16 of 16 results
Advanced filters: Author: Andrew Willmore Clear advanced filters

  • AlphaFold 3 has a substantially updated architecture that is capable of predicting the joint structure of complexes including proteins, nucleic acids, small molecules, ions and modified residues with greatly improved accuracy over many previous specialized tools.

    • Josh Abramson
    • Jonas Adler
    • John M. Jumper
    ResearchOpen Access
    Nature
    Volume: 630, P: 493-500

  • Auditory contrast gain control helps us perceive sounds as constant despite changes in the environment or background noise. Here, the authors show that neurons in the auditory thalamus and midbrain of mice display independent contrast gain control, not just the cortex as previously thought.

    • Michael Lohse
    • Victoria M. Bajo
    • Ben D. B. Willmore
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-13

    • ANDREW MILLER
    Books & Arts
    Nature
    Volume: 241, P: 222

  • Jayavelu, Samaha et al., apply machine learning models on hospital admission data, including antibody titers and viral load, to identify patients at high risk for Long COVID. Low antibody levels, high viral loads, chronic diseases, and female sex are key predictors, supporting early, targeted interventions.

    • Naresh Doni Jayavelu
    • Hady Samaha
    • Matthew C. Altman
    ResearchOpen Access
    Communications Medicine
    Volume: 6, P: 1-10

  • Here, the authors perform transcriptional profiling on tracheal aspirates of adults requiring mechanical ventilation for SARS-CoV2-induced acute respiratory distress syndrome (ARDS) and identify a dysregulated host response predicted to predicted to be potentially modulated by dexamethasone.

    • Aartik Sarma
    • Stephanie A. Christenson
    • Charles R. Langelier
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-10

  • Dexamethasone has been used in the treatment of critically ill COVID-19 patients. Here the authors apply transcriptomics to investigate the effects of dexamethasone treatment in COVID-19 patients, and show both systemic and compartment-specific effects.

    • Lucile P. A. Neyton
    • Ravi K. Patel
    • Gabriela K. Fragiadakis
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-14

  • Solid organ transplant recipients are at increased risk of infectious disease and have unique molecular pathophysiology. Here the authors use host-microbe profiling to assess SARS-CoV-2 infection and immunity in solid organ transplant recipients, showing enhanced viral abundance, impaired clearance, and increased expression of innate immunity genes.

    • Harry Pickering
    • Joanna Schaenman
    • Charles R. Langelier
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • The role of IgG glycosylation in the immune response has been studied, but less is known about IgM glycosylation. Here the authors characterize glycosylation of SARS-CoV-2 spike specific IgM and show that it correlates with COVID-19 severity and affects complement deposition.

    • Benjamin S. Haslund-Gourley
    • Kyra Woloszczuk
    • Mary Ann Comunale
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-19

  • The clinical course of chronic lymphocytic leukaemia (CLL) is variable and difficult to predict. Here, the authors conduct a genome wide association study meta-analysis for time to first treatment in CLL patients and report two loci associating with progressive disease.

    • Wei-Yu Lin
    • Sarah E. Fordham
    • James M. Allan
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-8

  • Post-acute sequelae of SARS-CoV-2 (PASC) is still not well understood. Here the authors provide patient reported outcomes from 590 hospitalized COVID-19 patients and show association of PASC with higher respiratory SARS-CoV-2 load and circulating antibody titers, and in some an elevation in circulating fibroblast growth factor 21.

    • Al Ozonoff
    • Naresh Doni Jayavelu
    • Nadine Rouphael
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17

  • In this work, authors assess airway microbiome dynamics to show bacterial pneumonia in critically ill COVID-19 patients is significantly associated with death, corticosteroid treatment, disruption of the lung microbiome and a distinct pulmonary host response.

    • Natasha Spottiswoode
    • Alexandra Tsitsiklis
    • Charles R. Langelier
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16

  • The authors use chromophore-targeted laser photolysis to selectively kill pyramidal neurons that project from auditory cortex to the inferior colliculus. They find that this eliminates the experience-dependent recalibration of sound localization, while leaving normal sound localization intact, implicating this pathway in learning-induced plasticity.

    • Victoria M Bajo
    • Fernando R Nodal
    • Andrew J King
    Research
    Nature Neuroscience
    Volume: 13, P: 253-260

  • This study shows that auditory development is guided by multiple adaptive processes. This flexibility can help maintain accurate perception in different environments and provides a more unified account of developmental plasticity across species. The adaptive plasticity observed also provides insight into the nature of distributed neural representations underlying spatial hearing.

    • Peter Keating
    • Johannes C Dahmen
    • Andrew J King
    Research
    Nature Neuroscience
    Volume: 18, P: 185-187

  • Primary auditory cortex is usually thought to be directly analogous to primary visual cortex, with stimulus physical properties being represented at this level. This perspective argues that the auditory system has unique operating principles that make it different from the visual system, such as considerably greater subcortical processing.

    • Andrew J King
    • Israel Nelken
    Reviews
    Nature Neuroscience
    Volume: 12, P: 698-701