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Advanced filters: Author: Angelika Caputo Clear advanced filters

Oral splicing modulator branaplam in Huntington’s disease: a phase 2 randomized controlled trial

Early results from the phase 2b VIBRANT-HD trial of the oral splicing modulator branaplam in Huntington’s disease suggested reduced cerebrospinal fluid huntingtin levels, but safety monitoring revealed signs of peripheral neurotoxicity, prompting early termination of the study.

Beth Borowsky
Harry Ramos
Blair R. Leavitt
ResearchOpen Access05 Jan 2026
Nature Medicine

Volume: 32, P: 103-112
TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease

Jane A. Gross
Janet Johnston
Christopher H. Clegg
Research27 Apr 2000
Nature

Volume: 404, P: 995-999

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Oral splicing modulator branaplam in Huntington’s disease: a phase 2 randomized controlled trial

TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease

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