An aromatic hydrogen bond—an interaction between the π-electron cloud of an aromatic ring and a hydrogen-bond donor—can substitute for a conventional hydrogen bond in sequence-specific protein—DNA interactions and can contribute 0.5–1 kcal mol−1 to binding and 1–2 kcal mol−1 to specificity.
- Gary Parkinson
- Angelo Gunasekera
- Richard H. Ebright
