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Hippocampal network activity forecasts epileptic seizures

Momentary snapshots of hippocampal brain activity may provide daily seizure forecasts in epilepsy.

Ankit N. Khambhati
Edward F. Chang
Vikram R. Rao
Research12 Jul 2024
Nature Medicine

Volume: 30, P: 2787-2790
Decoding naturalistic affective behaviour from spectro-spatial features in multiday human iEEG

How do brain networks encode naturalistic affective behaviours? Bijanzadeh et al. show that positive and negative affective behaviours are associated with increased high-frequency and decreased low-frequency activity across the mesolimbic network.

Maryam Bijanzadeh
Ankit N. Khambhati
Edward F. Chang
Research10 Mar 2022
Nature Human Behaviour

Volume: 6, P: 823-836
Functional brain network reconfiguration during learning in a dynamic environment

Adaptive adjustments in learning dynamics are accompanied by dynamic changes in a pattern of whole-brain functional connectivity characterized by integration between fronto-parietal and other networks. These dynamic functional connectivity changes also track individual differences in learning.

Chang-Hao Kao
Ankit N. Khambhati
Joseph W. Kable
ResearchOpen Access03 Apr 2020
Nature Communications

Volume: 11, P: 1-13
Invasive brain mapping identifies personalized therapeutic neuromodulation targets that suppress OCD network activity

A. Moses Lee
Audrey Kist
Andrew D. Krystal
ResearchOpen Access31 Oct 2025
Translational Psychiatry

Volume: 15, P: 1-7
Closed-loop neuromodulation in an individual with treatment-resistant depression

This case report describes a biomarker-driven closed-loop therapy for depression using implanted electrodes to continually sense brain activity and automatically trigger direct brain electrical stimulation in high-depression states.

Katherine W. Scangos
Ankit N. Khambhati
Edward F. Chang
Research04 Oct 2021
Nature Medicine

Volume: 27, P: 1696-1700
Closed-loop neurostimulation for the treatment of psychiatric disorders

Kristin K. Sellers
Joshua L. Cohen
Andrew D. Krystal
Reviews27 Jun 2023
Neuropsychopharmacology

Volume: 49, P: 163-178

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Hippocampal network activity forecasts epileptic seizures

Decoding naturalistic affective behaviour from spectro-spatial features in multiday human iEEG

Functional brain network reconfiguration during learning in a dynamic environment

Invasive brain mapping identifies personalized therapeutic neuromodulation targets that suppress OCD network activity

Closed-loop neuromodulation in an individual with treatment-resistant depression

Closed-loop neurostimulation for the treatment of psychiatric disorders

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