The human gut virome includes understudied viruses that infect archaea. Here, Baquero et al. characterize a temperate archaeal virus that infects the dominant methanogenic archaeon of the human gut, shedding light on archaeal virus-host interactions and highlighting similarities with gut bacteriophages in establishing stable coexistence with their hosts.
- Diana P. Baquero
- Sofia Medvedeva
- Mart Krupovic