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Showing 1–3 of 3 results
Advanced filters: Author: Annabelle Biscans Clear advanced filters

  • Therapeutic modulation of Janus kinase family enzymes is an established approach for inflammatory and autoimmune skin diseases. Here the authors rationally design small interfering RNAs to enable single Janus kinase targeting and test this new therapeutic approach in a skin disease model for maintaining efficacy and improving selectivity.

    • Qi Tang
    • Hassan H. Fakih
    • John E. Harris
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15

  • Progress in the development of RNA-based therapeutics has been accelerated by the identification of organ-enriching carriers and cell-specific targeting conjugates, leading to their approval for a range of indications. However, attempts to develop RNA-based therapeutics for kidney diseases have proved challenging. This Review describes the physiological, technological and pharmacological hurdles that need to be overcome to realize the potential of RNA therapeutic approaches to kidney diseases.

    • Jurriën Prins
    • Annabelle Biscans
    • Eric P. van der Veer
    Reviews
    Nature Reviews Nephrology
    Volume: 22, P: 12-29