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Methods to demonstrate genomic linkages between pathogens across One Health compartments have not been established. Here, the authors compile a collection of E coli genomes from humans, animals, and the environment in Australia and investigate genomic evidence of cross-source clusters.

Silicon ICs are key to neural implants but face reliability challenges. Here, the authors show bare die ICs can be inherently hermetic, and PDMS encapsulation limits degradation over 12 months, offering insights to enhance active implant longevity for biomedical use.

High plating currents are achieved in solid-state batteries without dendrites by densifying Li₆PS₅Cl, with modelling showing how specific microstructural changes increase the critical current density.

Here the authors show that the telomere repeat-containing RNA (TERRA) undergoes phase separation with the lysine-specific demethylase 1A (LSD1) to promote R-loop formation for homology-directed telomere DNA synthesis in the alternative lengthening of telomere (ALT) pathway.

Mesenchymal Stromal Cells are hard to expand whilst retaining immunomodulatory properties due to spontaneous differentiation and ageing in culture. Here, the authors describe a mechanotransductive link between metabolism and functional activity and identify bioactive metabolites to expand functional MSCs at cell therapy scale.

What are the minimal hardware requirements for a given class of sensing problems? Here, authors investigate this while proposing a miniaturized near-infrared spectral sensor, based on an array of resonant-cavity enhanced photodetectors, and capable of operating without the need for spectral reconstruction.

Effects of habitat restoration on belowground organisms and ecosystem processes are poorly understood. Morriën and colleagues show that changes in the composition and network interactions of soil biota lead to improved carbon uptake efficiency when formerly cultivated land is restored.

Association analyses in over 1 million individuals identify 535 new loci influencing blood pressure traits. The results provide new insights into blood pressure regulation and highlight shared genetic architecture between blood pressure and lifestyle exposures.

Vaccination is effective in protecting from COVID-19. Here the authors report immune responses and breakthrough infections in twice-vaccinated patients receiving anti-TNF treatments for inflammatory bowel disease, and find dampened vaccine responses that implicate the need of adapted vaccination schedules for these patients.

Transplantation of pancreatic islet cells encapsulated in alginate microspheres into the omental bursa of the peritoneal cavity of NHPs significantly reduces FBRs and extends the longevity of the cells.

Lymphocytes must rapidly scan lymph nodes for cognate antigens. Krummel and colleagues show that myosin IIA acts to optimize cell motility by regulating cell contacts through lymph node stromal environments.

The serial interval (time between symptom onset in an infector and infectee) is usually estimated from contact tracing data, but this is not always available. Here, the authors develop a method for estimation of serial intervals using whole genome sequencing data and apply it data from clusters of SARS-CoV-2 in Victoria, Australia.

Age-related macular degeneration (AMD) is a leading cause of vision loss, and there is no approved treatment for AMD with geographic atrophy. Here, the authors used transcriptomic and proteomic analyses of patient induced pluripotent stem cell-derived retinal pigment epithelium to better understand disease mechanisms.

Sustaining marine biodiversity and socio-ecological systems requires strategic planning. This study finds that a bioregional planning approach can protect representative environments in the Southern Ocean given the political will to iteratively adapt existing and proposed Marine Protected Areas.

Here, Reader et al. screen the Medicines for Malaria Venture Pandemic Response Box in parallel against Plasmodiumasexual and liver stage parasites, stage IV/V gametocytes, gametes, oocysts and as endectocides. They identify two potent transmission-blocking drugs: a histone demethylase inhibitor ML324 and the antitubercular SQ109.

Genetic and phenotypic analysis reveals expression quantitative trait loci in human induced pluripotent stem cell lines associated with cancer and disease.

Analysis of whole-genome sequences of 25,465 individuals of European ancestry shows that rare variants contribute substantially to the heritability of height and body mass index.

Whole-genome sequencing analysis of individuals with primary immunodeficiency identifies new candidate disease-associated genes and shows how the interplay between genetic variants can explain the variable penetrance and complexity of the disease.

Edward B. Barbier and colleagues call for governance and funds for deep-sea reserves and the restoration of ecosystems damaged by commercial interests.

Investigation of variation in three cohorts has identified multiple genetic signals associated with the pregnancy-specific liver disorder, intrahepatic cholestasis of pregnancy, giving insight into the disease which can cause preterm birth and stillbirth.

Mark Caulfield, Paul Elliott and colleagues use data from the UK Biobank to perform genome-wide association analysis for blood pressure traits. They identify and validate 107 novel loci and highlight new biological pathways for potential therapeutic intervention for hypertension.

The methylation of non-CpG residues is a poorly understood marker of pluripotent cells, gradually lost as cells differentiate. Here the authors show non-CG methylation can be used as a marker of differentiation potential.

Whole-genome sequencing and phenotype data sharing are introduced in a national health system to streamline diagnosis and to discover coding and non-coding variants that cause rare diseases.

Studying the genetic effects on early stages of human development is challenging due to a scarcity of biological material. Here, the authors utilise induced pluripotent stem cells from 125 donors to track gene expression changes and expression quantitative trait loci at single cell resolution during in vitro endoderm differentiation.

Predictions suggest that a high proportion of plant species will be threatened with extinction in the near future. A global assessment of the threat status of cacti suggests that these iconic plants are amongst the most threatened taxonomic groups, with 31% of the 1,478 evaluated species at risk of extinction.

This Review showcases the research progress and prospects of spintronic logic, which encodes information using spin and magnetism. Focusing on five exemplary types, we discuss the promise, challenges and future research directions in the context of high-performance computing needs.

Repair of defects in the common bile duct is hampered by a lack of healthy donor tissue. Developing human extrahepatic cholangiocyte organoids and testing them in mouse models may provide a way to overcome this limitation.

Digital technology is increasingly being used to address food security issues against the backdrop of anthropogenic stressors such as climate change and resource scarcity. This Perspective discusses ways to effectively deploy edge AI in food production systems to improve agricultural sustainability.

Large grassland and open savannah fires occurred during humid periods of the Holocene in subtropical Africa and contributed to increased carbon dioxide in the atmosphere, according to the concentration and morphotype of microcharcoals in marine sediments off Africa

Fibroblasts constitute the major mesenchymal cell type in the connective tissue and their functions are remarkably diverse: here, by characterising lineages of mouse skin fibroblasts, it is shown that distinct subpopulations contribute to skin development and repair during injury.

Cardelino leverages variant information from single-cell RNA-seq data for inferring clonal tree configuration and mapping cells to their clone of origin.