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Showing 1–3 of 3 results
Advanced filters: Author: Annerieke Sierksma Clear advanced filters

  • Muscularis macrophages, housekeepers of enteric nervous system integrity and intestinal homeostasis, modulate α-synuclein pathology and neurodegeneration in models of Parkinson’s disease, and understanding the accompanying mechanisms could pave the way for early-stage biomarkers.

    • Sebastiaan De Schepper
    • Viktoras Konstantellos
    • Tim Bartels
    ResearchOpen Access
    Nature
    P: 1-11

  • While polygenic risk scores have been shown to be correlated with disease risk, there is little agreement on how the score should be calculated. Here the authors investigate risk scores for Alzheimer’s disease, finding that the most effective approach includes an APOE score and a polygenic score excluding APOE.

    • Ganna Leonenko
    • Emily Baker
    • Valentina Escott-Price
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-10

  • Human stem cell-derived microglia integrate into mouse brain, displaying transcriptome signatures of microglia directly isolated from human brain and providing a chimeric model to study human-specific aspects of Alzheimer’s disease and other brain diseases.

    • Renzo Mancuso
    • Johanna Van Den Daele
    • Bart De Strooper
    Research
    Nature Neuroscience
    Volume: 22, P: 2111-2116