FcγRI binds immune complex (IC) to contribute to various autoimmune diseases, but a specific blocking antibody has not been reported. Here the authors characterize two anti-FcγRI antibodies that block and replace IC-binding to FcγRI in the context of patient-derived samples or a mouse immune thrombocytopenia model to implicate potential clinical translation.
- Tosca Holtrop
- Arianne M. Brandsma
- Jeanette H. W. Leusen
