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Showing 1–8 of 8 results
Advanced filters: Author: Ansgar Zoch Clear advanced filters

  • In mice, a SPOCD1–TPR-dependent ‘nowhere-to-hide’ mechanism is required for complete non-stochastic piRNA-directed LINE1 DNA methylation by preventing transposons from escaping surveillance within heterochromatin.

    • Tamoghna Chowdhury
    • Shelagh Boyle
    • Dónal O’Carroll
    Research
    Nature
    P: 1-7

  • In male mouse germline development, the precise DNA methylation of young, active transposons requires a two-step process in which SPIN1 and SPOCD1 mark young LINE1 elements before the piRNA pathway triggers DNA methylation.

    • Madeleine Dias Mirandela
    • Ansgar Zoch
    • Dónal O’Carroll
    ResearchOpen Access
    Nature
    Volume: 634, P: 979-985

  • Cells often migrate in tightly connected groups with coordinated movement and polarity. The collective migration of epithelial cell sheets is now shown to be mediated by a signalling axis that involves the merlin tumour-suppressor protein, the tight-junction-associated angiomotin–Rich1 complex and the Rac1 small GTPase.

    • Ansgar Zoch
    • Helen Morrison
    News & Views
    Nature Cell Biology
    Volume: 17, P: 212-213

  • The PIWI protein MIWI2 counteracts transposon activity by transcriptional silencing in the mammalian germline. Here, the authors show that TEX15 interacts with MIWI2 and is required for piRNA-directed methylation of transposable elements in male germ cells.

    • Theresa Schöpp
    • Ansgar Zoch
    • Dónal O’Carroll
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-8

  • Neurofibromatosis type 2 (NF2) is caused by inactivation of the NF2 gene, which encodes merlin. NF2 patients develop peripheral neuropathies. The authors show that NF2 inactivation decreases axonal integrity in mice and NF2 patient tissue. Their data suggest that merlin activates RhoA and promotes neurofilament heavy chain phosphorylation to maintain axonal integrity.

    • Alexander Schulz
    • Stephan L Baader
    • Helen Morrison
    Research
    Nature Neuroscience
    Volume: 16, P: 426-433

  • PIWI-interacting RNAs (piRNAs) have numerous crucial biological roles, particularly transposon silencing in the germ line. In this Review, the authors describe our latest understanding of piRNA biogenesis and functions across diverse species, highlighting how, despite the universal importance of transposon control, different species have evolved intriguingly distinct mechanistic routes to achieve this.

    • Deniz M. Ozata
    • Ildar Gainetdinov
    • Phillip D. Zamore
    Reviews
    Nature Reviews Genetics
    Volume: 20, P: 89-108