Nature Search

Paternal SARS-CoV-2 infection impacts sperm small noncoding RNAs and increases anxiety in offspring in a sex-dependent manner

Whether paternal pre-conceptual SARS-CoV-2 infection impacts sperm RNA content, or effects offspring phenotypes, has not been previously investigated. Here authors report changes in sperm noncoding RNAs in SARS-CoV-2 infected sires and increased anxiety-like behaviors in offspring.

Elizabeth A. Kleeman
Carolina Gubert
Anthony J. Hannan
ResearchOpen Access11 Oct 2025
Nature Communications

Volume: 16, P: 1-21
Characterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Cecilia Anza-Ramirez
J. Jaime Miranda
Yves Miel H. Zuniga
ResearchOpen Access07 May 2025
Nature Communications

Volume: 16, P: 1-36
A novel PLpro inhibitor improves outcomes in a pre-clinical model of long COVID

A novel antiviral targeting the SARS-CoV-2 PLpro protease shows strong efficacy in a mouse model, preventing lung pathology and reducing brain dysfunction. The study provides proof-of-principle that PLpro inhibition may be a viable strategy for preventing and treating long COVID.

Stefanie M. Bader
Dale J. Calleja
David Komander
ResearchOpen Access03 Apr 2025
Nature Communications

Volume: 16, P: 1-20
Repeat DNA expands our understanding of autism spectrum disorder

A link has been found between repetitive stretches of DNA called tandem repeats and autism spectrum disorder. The discovery might inform approaches to studying tandem repeats in a wide range of other human disorders.

Anthony J. Hannan
News & Views13 Jan 2021
Nature

Volume: 589, P: 200-202
The HASTER lncRNA promoter is a cis-acting transcriptional stabilizer of HNF1A

Beucher et al. show that the promoter of lncRNA HASTER is a cis-regulatory feedback element that stabilizes HNF1A concentrations.

Anthony Beucher
Irene Miguel-Escalada
Jorge Ferrer
ResearchOpen Access06 Oct 2022
Nature Cell Biology

Volume: 24, P: 1528-1540
Transcriptomic signatures in brain and blood related to cognitive and psychiatric phenotypes of Prader–Willi syndrome

Shokouh Shahrokhi
Emma K. Baker
David E. Godler
ResearchOpen Access24 Dec 2025
Scientific Reports

Volume: 16, P: 1-11
Developmental origins of mental health and disorders (DOMHaD): an approach to understanding, preventing and treating psychiatric disorders

This Perspective presents the developmental origins of mental health and disorders (DOMHaD) framework, emphasizing genetic, environmental and epigenetic influences on psychiatric conditions. It highlights interactions over time, revealing pathways for understanding, preventing and treating these complex disorders effectively.

Sonali N. Reisinger
Anthony J. Hannan
Reviews18 Sept 2025
Nature Mental Health

Volume: 3, P: 1116-1136
LINE-1 retrotransposons contribute to mouse PV interneuron development

LINE-1 retrotransposons are a type of mobile DNA element normally repressed in the body. Here the authors show that LINE-1 sequences can jump in mouse parvalbumin interneurons and also promote the transcription of key parvalbumin interneuron genes.

Gabriela O. Bodea
Juan M. Botto
Geoffrey J. Faulkner
ResearchOpen Access21 May 2024
Nature Neuroscience

Volume: 27, P: 1274-1284
Viral regulation of host cell biology by hijacking of the nucleolar DNA-damage response

Many RNA viruses that replicate in the cytoplasm express proteins that localize to nucleoli, but the nucleolar functions remain largely unknown. Here, the authors show that the Henipavirus matrix protein mimics an endogenous Treacle partner of the DNA-damage response, resulting in suppression of rRNA biogenesis.

Stephen M. Rawlinson
Tianyue Zhao
Gregory W. Moseley
ResearchOpen Access03 Aug 2018
Nature Communications

Volume: 9, P: 1-13
Delaying the onset of Huntington's in mice

This unremitting disease develops later in animals stimulated by their environment.

Anton van Dellen
Colin Blakemore
Anthony J. Hannan
Research13 Apr 2000
Nature

Volume: 404, P: 721-722
PLC-β1, activated via mGluRs, mediates activity-dependent differentiation in cerebral cortex

Anthony J. Hannan
Colin Blakemore
Peter C. Kind
Research01 Mar 2001
Nature Neuroscience

Volume: 4, P: 282-288
Exercise mimetics: harnessing the therapeutic effects of physical activity

Physical activity has demonstrated positive effects in preventing and ameliorating a broad range of diseases, particularly central nervous system disorders. Accordingly, strategies to therapeutically mimic the effects of exercise are gaining interest. Here, Gubert and Hannan focus on the molecular and cellular effects of physical activity in the central nervous system, assessing opportunities for the development of therapeutic exercise mimetics.

Carolina Gubert
Anthony J. Hannan
Reviews08 Jun 2021
Nature Reviews Drug Discovery

Volume: 20, P: 862-879
Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission

In this study, Aggarwal and colleagues perform prospective sequencing of SARS-CoV-2 isolates derived from asymptomatic student screening and symptomatic testing of students and staff at the University of Cambridge. They identify important factors that contributed to within university transmission and onward spread into the wider community.

Dinesh Aggarwal
Ben Warne
Ian G. Goodfellow
ResearchOpen Access08 Feb 2022
Nature Communications

Volume: 13, P: 1-16
Genomic characterisation of Eμ-Myc mouse lymphomas identifies Bcor as a Myc co-operative tumour-suppressor gene

The Eμ-Myc lymphoma mouse model has been invaluable in the study of this disease. Here, the authors use multiple sequencing strategies to analyse the tumours in these mice and find recurrent inactivating mutations in Bcor, suggesting that this gene has a negative role in Mycsignalling.

Marcus Lefebure
Richard W. Tothill
Ricky W. Johnstone
ResearchOpen Access06 Mar 2017
Nature Communications

Volume: 8, P: 1-10
Environmental Enrichment Ameliorates Behavioral Impairments Modeling Schizophrenia in Mice Lacking Metabotropic Glutamate Receptor 5

Emma L Burrows
Caitlin E McOmish
Anthony J Hannan
Research10 Feb 2015
Neuropsychopharmacology

Volume: 40, P: 1947-1956
Neurodesk: an accessible, flexible and portable data analysis environment for reproducible neuroimaging

Neurodesk is a platform for analyzing human neuroimaging data, which provides numerous tools in a containerized form, thereby ensuring reproducibility and portability.

Angela I. Renton
Thuy T. Dao
Steffen Bollmann
Research08 Jan 2024
Nature Methods

Volume: 21, P: 804-808
Touchscreen testing reveals clinically relevant cognitive abnormalities in a mouse model of schizophrenia lacking metabotropic glutamate receptor 5

Ariel M. Zeleznikow-Johnston
Thibault Renoir
Anthony J. Hannan
ResearchOpen Access06 Nov 2018
Scientific Reports

Volume: 8, P: 1-10
Professor Sir Colin Blakemore FRS, a brilliant force for good within neuroscience and beyond (1944–2022)

Zoltán Molnár
Anthony J. Hannan
Comments & Opinion01 Aug 2022
Nature Neuroscience

Volume: 25, P: 1249-1250
Enriched environments, experience-dependent plasticity and disorders of the nervous system

Enhanced novelty and complexity in the environment can have impressive effects on experience-dependent plasticity under normal conditions. Moreover, such enriched environments can delay the onset and progression of a range of CNS disorders, with important implications for therapeutic strategies.

Jess Nithianantharajah
Anthony J. Hannan
Reviews01 Sept 2006
Nature Reviews Neuroscience

Volume: 7, P: 697-709
Tandem repeats mediating genetic plasticity in health and disease

DNA repeats are more liable to mutation than other genetic variants, which enables them to mediate genetic plasticity. The expansion of tandem repeats can cause a range of monogenic disorders, contribute to the missing heritability of polygenic disorders and regulate gene expression, as well as RNA and protein function, in healthy individuals.

Anthony J. Hannan
Reviews05 Feb 2018
Nature Reviews Genetics

Volume: 19, P: 286-298
Plasma metabolites are altered before and after diagnosis of preeclampsia or fetal growth restriction

Lucy A. Bartho
Daniel R. McKeating
Tu’uhevaha J. Kaitu’u-Lino
ResearchOpen Access09 Jul 2024
Scientific Reports

Volume: 14, P: 1-11
Chronically high stress hormone levels dysregulate sperm long noncoding RNAs and their embryonic microinjection alters development and affective behaviours

L. B. Hoffmann
B. Li
A. J. Hannan
Research19 Dec 2023
Molecular Psychiatry

Volume: 29, P: 590-601
Of mice, molecules and mental health: establishment of the consortium for preclinical psychiatric research to find solutions to the translational gap

Rachel A. Hill
Eslam M. Bastawy
Suresh Sundram
Comments & Opinion28 Nov 2025
Molecular Psychiatry

Volume: 31, P: 1167-1170
Letter to the editor: Comments on ‘Striking long-term beneficial effects of single-dose psilocybin and psychedelic mushroom extract in the SAPAP3 rodent model of OCD-like excessive self-grooming’ by Brownstien et al. (2024)

James J. Gattuso
Carey Wilson
Thibault Renoir
Comments & OpinionOpen Access06 Apr 2025
Molecular Psychiatry

Volume: 30, P: 3829-3832
Transgenerational epigenetic influences of paternal environmental exposures on brain function and predisposition to psychiatric disorders

Shlomo Yeshurun
Anthony J. Hannan
Reviews08 Mar 2018
Molecular Psychiatry

Volume: 24, P: 536-548
Exercise alters mouse sperm small noncoding RNAs and induces a transgenerational modification of male offspring conditioned fear and anxiety

A K Short
S Yeshurun
A J Hannan
ResearchOpen Access02 May 2017
Translational Psychiatry

Volume: 7, P: e1114
Phospholipase C-β1 knockout mice exhibit endophenotypes modeling schizophrenia which are rescued by environmental enrichment and clozapine administration

C E McOmish
E Burrows
A J Hannan
Research31 Jul 2007
Molecular Psychiatry

Volume: 13, P: 661-672
CaMKK2 as an emerging treatment target for bipolar disorder

Jacqueline Kaiser
Kevin Nay
John W. Scott
ReviewsOpen Access20 Sept 2023
Molecular Psychiatry

Volume: 28, P: 4500-4511
How the evolution of multicellularity set the stage for cancer

Anna S Trigos
Richard B Pearson
David L Goode
ReviewsOpen Access16 Jan 2018
British Journal of Cancer

Volume: 118, P: 145-152

Search

Paternal SARS-CoV-2 infection impacts sperm small noncoding RNAs and increases anxiety in offspring in a sex-dependent manner

Characterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019

A novel PLpro inhibitor improves outcomes in a pre-clinical model of long COVID

Repeat DNA expands our understanding of autism spectrum disorder

The HASTER lncRNA promoter is a cis-acting transcriptional stabilizer of HNF1A

Transcriptomic signatures in brain and blood related to cognitive and psychiatric phenotypes of Prader–Willi syndrome

Developmental origins of mental health and disorders (DOMHaD): an approach to understanding, preventing and treating psychiatric disorders

LINE-1 retrotransposons contribute to mouse PV interneuron development

Viral regulation of host cell biology by hijacking of the nucleolar DNA-damage response

Delaying the onset of Huntington's in mice

PLC-β1, activated via mGluRs, mediates activity-dependent differentiation in cerebral cortex

Exercise mimetics: harnessing the therapeutic effects of physical activity

Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission

Genomic characterisation of Eμ-Myc mouse lymphomas identifies Bcor as a Myc co-operative tumour-suppressor gene

Environmental Enrichment Ameliorates Behavioral Impairments Modeling Schizophrenia in Mice Lacking Metabotropic Glutamate Receptor 5

Neurodesk: an accessible, flexible and portable data analysis environment for reproducible neuroimaging

Touchscreen testing reveals clinically relevant cognitive abnormalities in a mouse model of schizophrenia lacking metabotropic glutamate receptor 5

Professor Sir Colin Blakemore FRS, a brilliant force for good within neuroscience and beyond (1944–2022)

Enriched environments, experience-dependent plasticity and disorders of the nervous system

Tandem repeats mediating genetic plasticity in health and disease

Plasma metabolites are altered before and after diagnosis of preeclampsia or fetal growth restriction

Chronically high stress hormone levels dysregulate sperm long noncoding RNAs and their embryonic microinjection alters development and affective behaviours

Of mice, molecules and mental health: establishment of the consortium for preclinical psychiatric research to find solutions to the translational gap

Letter to the editor: Comments on ‘Striking long-term beneficial effects of single-dose psilocybin and psychedelic mushroom extract in the SAPAP3 rodent model of OCD-like excessive self-grooming’ by Brownstien et al. (2024)

Transgenerational epigenetic influences of paternal environmental exposures on brain function and predisposition to psychiatric disorders

Exercise alters mouse sperm small noncoding RNAs and induces a transgenerational modification of male offspring conditioned fear and anxiety

Phospholipase C-β1 knockout mice exhibit endophenotypes modeling schizophrenia which are rescued by environmental enrichment and clozapine administration

CaMKK2 as an emerging treatment target for bipolar disorder

How the evolution of multicellularity set the stage for cancer

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