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Showing 1–8 of 8 results
Advanced filters: Author: Antonina Hafner Clear advanced filters

  • Transcription factors (TFs) represent an emerging class of therapeutic targets in oncology. Here, the authors develop Epiregulon, a computational method that constructs gene regulatory networks from ChIP-seq, ATAC-seq and RNA-seq data for accurate prediction of TF activity at the single-cell level, thereby facilitating the discovery of therapeutics targeting TFs.

    • Tomasz Włodarczyk
    • Aaron Lun
    • Xiaosai Yao
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19

  • Non-coding variants can regulate transcription factor binding and gene expression at variable chromatin modules. Here, the authors show that a germline variant induces transcription factor nucleation through chromatin compaction leading to AXIN2 up-regulation and is associated to better prognosis in chronic lymphocytic leukaemia.

    • Gerard Llimos
    • Vincent Gardeux
    • Bart Deplancke
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-21

  • Chemical genetic dissection of the SWI/SNF–Polycomb axis in mouse stem cells identifies an unexpected role for mSWI/SNF in repression, providing mechanistic insight into the dynamic ‘tug of war’ between transcriptional activation and repression.

    • Christopher M. Weber
    • Antonina Hafner
    • Gerald R. Crabtree
    Research
    Nature Structural & Molecular Biology
    Volume: 28, P: 501-511

  • This Review discusses how chromosome tracing has deepened our understanding of the role of 3D chromatin topology in transcriptional regulation by helping to resolve open questions and opposing models rising from data generated by sequencing-based approaches, such as 3C and HiC.

    • Antonina Hafner
    • Alistair Boettiger
    Reviews
    Nature Reviews Genetics
    Volume: 24, P: 53-68

  • Following DNA damage, the transcription factor p53 determines whether cells undergo apoptosis or cell cycle arrest and DNA repair. To enable different cellular outcomes, p53 is regulated through its temporal expression dynamics and post-translational modification, and by interactions with chromatin, chromatin regulators and transcription factors.

    • Antonina Hafner
    • Martha L. Bulyk
    • Galit Lahav
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 20, P: 199-210