Type II chaperonins, such as CCT, and Hsp70 class chaperones, such as Hsc70, have crucial roles in protein folding and share some substrate overlap. Structural data now indicate that a complex forms between the β subunit of CCT and Hsc70, suggesting a coordinated hand-off mechanism for substrate interactions.
- Jorge Cuéllar
- Jaime Martín-Benito
- José M Valpuesta
