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Showing 1–4 of 4 results
Advanced filters: Author: Argyro Kalogeropoulou Clear advanced filters

  • Re-replication is a driving force of tumorigenesis and genomic instability. Here, the authors show that upon re-replication, FANCD2 localizes at early origins to limit replisome progression, ssDNA gap accumulation and fork breakage, revealing a vulnerability for selective targeting of cancer cells.

    • Nibal Badra-Fajardo
    • Elena Karydi
    • Zoi Lygerou
    ResearchOpen Access
    Nature Communications
    P: 1-22

  • Epithelioids are genetically stable, self-sustaining three-dimensional cultures. They may be used to investigate various aspects of epithelial biology over several months without need for passaging. In this paper, mouse epithelioids are used to identify drivers of clonal expansion in the esophagus.

    • Albert Herms
    • David Fernandez-Antoran
    • Philip H. Jones
    ResearchOpen Access
    Nature Genetics
    Volume: 56, P: 2158-2173

  • Malignant pleural effusion (MPE) is a life-threatening cancer-related disorder. Here, the authors show that KRAS-mutant tumor cells require IKKα, activated via host-provided IL-1β, to promote MPE development and that co-inhibition of both KRAS and IKKα ameliorates the development of MPE in mouse models.

    • Antonia Marazioti
    • Ioannis Lilis
    • Georgios T. Stathopoulos
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-16