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Showing 1–9 of 9 results
Advanced filters: Author: Ariel B. Lindner Clear advanced filters

  • The reconstitution of complex biological processes in cell-free systems can support the detailed characterisation of biochemical mechanisms which are difficult to probe in vivo. Here authors present an all-cell-free T7 phage cycle, consisting of cell-sized liposomes encapsulating a cell-free gene expression reaction and a phage receptor at the membrane.

    • Antoine Levrier
    • Paul Soudier
    • Vincent Noireaux
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-12

  • Authors report a codon language representation and a model, CodonTransformer, open access and with a user-friendly interface. CodonTransformer generates species-specific DNA sequences with natural-like profiles and with minimum negative regulatory elements.

    • Adibvafa Fallahpour
    • Vincent Gureghian
    • Amir Pandi
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-12

  • Bacteriophages have great potential in both medicine and biotechnology. Here the authors present PHEIGES, a cell-free method for phage genome engineering, synthesis and selection based on T7, which allows direct selection of engineered and mutant phages without compartmentalization.

    • Antoine Levrier
    • Ioannis Karpathakis
    • Vincent Noireaux
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13

  • Whole-cell screening for Mycobacterium tuberculosis inhibitors is complicated by the pathogen’s slow growth and biocontainment requirements. Here the authors develop engineered E. coli as a synthetic biology tool to express and screen metabolic targets from Mycobacterium tuberculosis.

    • Nadine Bongaerts
    • Zainab Edoo
    • Edwin H. Wintermute
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-11

  • To understand why genetically identical cells die at different times the authors measured damage dynamics in individual cells. They report lifespan variation comes not from initial conditions but from stochastic accumulation of damage that saturates repair systems.

    • Yifan Yang
    • Omer Karin
    • Uri Alon
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-11

  • Deinococcus radiodurans is able to withstand high doses of radiation, despite the DNA damage caused. Genome fragments with regions of complementary sequence meet and initiate synthesis by a DNA polymerase to form long single-stranded ends on the fragments. The complementary single-strand tails then pair and regenerate long double-stranded DNA molecules that are processed into the original circular genome.

    • Ksenija Zahradka
    • Dea Slade
    • Miroslav Radman
    Research
    Nature
    Volume: 443, P: 569-573

  • Synthetic cells are artificial constructs designed to mimic cellular functions, offering insights into fundamental biology, as well as promising impact in the fields of medicine, biotechnology, and bioengineering. In this perspective, the authors highlight major scientific hurdles, such as the integration of functional modules by ensuring compatibility across diverse synthetic subsystems, and propose strategies to advance the field.

    • S. Giaveri
    • Z. Abil
    • I. N. Westensee
    ReviewsOpen Access
    Nature Communications
    Volume: 16, P: 1-6