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Showing 1–6 of 6 results
Advanced filters: Author: Arnaud Amzallag Clear advanced filters

  • Combination of drugs within cancer treatment is a popular way to overcome resistance and increase efficacy. Here, the authors analyse over 5000 targeted agent combinations in non-small cell lung cancer to identify potentially effective drug strategies.

    • Nishanth Ulhas Nair
    • Patricia Greninger
    • Cyril H. Benes
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-19

  • Synthetic lethality (SL) offers a new precision oncology approach, which is based on targeting cancer-specific vulnerabilities across the whole genome, going beyond cancer drivers. The authors develop an approach termed ISLE to identify clinically relevant SL interactions and use them for patient stratification and novel target identification.

    • Joo Sang Lee
    • Avinash Das
    • Eytan Ruppin
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-12

  • Here, a covalent inhibitor targeting cyclin-dependent kinase 7 (CDK7) demonstrates in vitro and in vivo efficacy against T-cell acute lymphoblastic leukaemia by downregulating oncogenic transcriptional programs.

    • Nicholas Kwiatkowski
    • Tinghu Zhang
    • Nathanael S. Gray
    Research
    Nature
    Volume: 511, P: 616-620

  • In panels of cancer cell lines analysed for their response to drug libraries, some studies have proposed distinct pharmacological sensitivities for some cell lines while other studies have not seen the same trends; here the data in the Cancer Cell Line Encyclopedia and the Genomics of Drug Sensitivity in Cancer are reassessed, and the authors report a stronger degree of concordance between the two data sets than that in a previous study.

    • Nicolas Stransky
    • Mahmoud Ghandi
    • Julio Saez-Rodriguez
    Research
    Nature
    Volume: 528, P: 84-87