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Showing 1–17 of 17 results
Advanced filters: Author: Arthur Mortha Clear advanced filters

  • A preprint by Guo et al. reports a mechanism of transcriptional control of RORγt expression in intestinal antigen-presenting cells that are important for oral tolerance involving the cis-regulatory region OCR369.

    • Alisa Iakupova
    • Arthur Mortha
    Research Highlights
    Nature Reviews Immunology
    Volume: 26, P: 4

  • A preprint by Wu et al. identifies BRD4 as a sensor of pH, with notable implications for the regulation of inflammatory genes.

    • Siu Ling Tai
    • Arthur Mortha
    Research Highlights
    Nature Reviews Immunology
    Volume: 25, P: 635

  • Circadian oscillation of gene expression controls gut tissue homeostasis. The transcription factors REV-ERBα and REV-ERBβ, which control the expression of clock genes, are also central to maintaining innate lymphoid cells in a state that facilitates the maintenance of a balanced and healthy intestine.

    • Siu Ling Tai
    • Louis Ngai
    • Arthur Mortha
    News & Views
    Nature Immunology
    Volume: 26, P: 1428-1429

  • A preprint by Kaltenbach et al. shows a role for cytoskeletal control mechanisms in contributing to the tissue maintenance of mast cells.

    • Louis Ngai
    • Arthur Mortha
    Research Highlights
    Nature Reviews Immunology
    Volume: 24, P: 541

  • Mouse lymphoid tissue–inducer (LTi) cells require the transcription factor RORγt. Cupedo's group identifies RORγt+ human LTi cell equivalents as committed natural killer cell precursors, and teams led by Vivier and Diefenbach describe RORγt-expressing interleukin 22–producing natural killer cells in mouse gut.

    • Stephanie L Sanos
    • Viet L Bui
    • Andreas Diefenbach
    Research
    Nature Immunology
    Volume: 10, P: 83-91

  • A preprint by Dhariwala et al. reports that monocytes in the skin of newborn mice suppress microbiota-driven inflammatory responses by sequestering IL-1 to prevent T cell activation.

    • Siu Ling Tai
    • Arthur Mortha
    Research Highlights
    Nature Reviews Immunology
    Volume: 24, P: 3

  • A preprint by Ramanan et al. examines the roles of accessory transcription factors in regulating subsets of colonic regulatory T cells, independently of the microbiota and T cell specificity.

    • Kyle Burrows
    • Arthur Mortha
    Research Highlights
    Nature Reviews Immunology
    Volume: 23, P: 544

  • Early dissemination of cancer cells has been reported to occur in certain breast cancer models. Here the authors show that intra-epithelial macrophages in the early pre-cancer lesions drive early cancer cell dissemination through Wnt-1 secretion and that such events impact the later development of metastasis.

    • Nina Linde
    • Maria Casanova-Acebes
    • Julio A. Aguirre-Ghiso
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-14

  • Eric Schadt and colleagues present a predictive causal model of the immune component of inflammatory bowel disease through integration of genetic, regulatory and transcriptional data. They prioritize and validate 12 of the top key drivers experimentally in mouse colitis models and human macrophages.

    • Lauren A Peters
    • Jacqueline Perrigoue
    • Eric E Schadt
    Research
    Nature Genetics
    Volume: 49, P: 1437-1449

  • Macrophages populate the body's tissues and organs, where they become highly specialized to preserve organ integrity in the event of microbial invasion or injury. A dynamic crosstalk between the macrophages and their surrounding tissue cells is crucial to ensuring this homeostatic function. This Review highlights the key molecules and mechanisms involved in macrophage–tissue interactions.

    • Yonit Lavin
    • Arthur Mortha
    • Miriam Merad
    Reviews
    Nature Reviews Immunology
    Volume: 15, P: 731-744

  • Neutrophil ageing, which encourages inflammation and vaso-occlusion in a mouse model of sickle-cell disease, is shown to depend on the intestinal microbiota and activation of the TLR/Myd88 signalling pathways.

    • Dachuan Zhang
    • Grace Chen
    • Paul S. Frenette
    Research
    Nature
    Volume: 525, P: 528-532

  • Nature Immunology’s 20th anniversary is a good opportunity to reminisce about the ImmGen collective endeavor — its goals, successes and horror stories — and the group’s exploration of various modes of scientific publishing.

    • Stephanie Vargas Aguilar
    • Oscar Aguilar
    • Caroline Ziemkiewicz
    Comments & Opinion
    Nature Immunology
    Volume: 21, P: 700-703