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Showing 1–6 of 6 results
Advanced filters: Author: Arthur Zalevsky Clear advanced filters

  • X-ray crystallography, cryo-electron microscopy, structural modelling, biochemistry, cell biology, and evolutionary analysis enable characterization of ORF2p, the reverse transcriptase of the ancient ‘parasitic’ LINE-1 retrotransposon that has written around one-third of the human genome.

    • Eric T. Baldwin
    • Trevor van Eeuwen
    • Martin S. Taylor
    ResearchOpen Access
    Nature
    Volume: 626, P: 194-206

  • Here, the authors evaluate the performance of AlphaFold2 and its predicted structures on common structural biological applications, including missense variants, function and ligand binding site prediction, modeling of interactions and modeling of experimental structural data.

    • Mehmet Akdel
    • Douglas E. V. Pires
    • Pedro Beltrao
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 29, P: 1056-1067

  • Orphan transporters can be found in over 20 families in the SLC superfamily. Here, the authors show that human SLC22A10 is a unitary pseudogene due to a fixed missense mutation, P220; while in great apes, its orthologs transport sex steroid conjugates.

    • Sook Wah Yee
    • Luis Ferrández-Peral
    • Kathleen M. Giacomini
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17

  • Ancient, asexual lineages are rare as a lack of recombination is usually an evolutionary dead end. Here, authors compare complete genomes of 11 individual bdelloid rotifers that suggest evidence of regular genetic exchange between individuals in a species that was previously thought to be asexual.

    • Olga A. Vakhrusheva
    • Elena A. Mnatsakanova
    • Alexey S. Kondrashov
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-17

  • Lushpa et al report the structure and dynamics of the TLR1 toll-interleukin like (TIR) cytoplasmic domain in both crystal and solution. They demonstrate that the TLR1 TIR domain is capable of specific binding of Zn with nanomolar affinity, which appears to be critical for receptor activation, and provide potential structures TLR1-TIR/Zn complex based on in silico data.

    • Vladislav A. Lushpa
    • Marina V. Goncharuk
    • Konstantin S. Mineev
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-12