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Showing 1–19 of 19 results
Advanced filters: Author: Astrid Gillich Clear advanced filters

  • Here the authors show that FGF signaling initiates alveolus development in mouse lung by inducing AT2 fate and a secondary signal for AT1 fate, and continuously maintains AT2 cells throughout life. FGF inhibition triggers immediate AT2 apoptosis and compensatory regeneration.

    • Douglas G. Brownfield
    • Alex Diaz de Arce
    • Mark A. Krasnow
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-14

  • Cell type labelling in single-cell datasets remains a major bottleneck. Here, the authors present AnnDictionary, an open-source toolkit that enables atlas-scale analysis and provides the first benchmark of LLMs for de novo cell type annotation from marker genes, showing high accuracy at low cost.

    • George Crowley
    • Robert C. Jones
    • Stephen R. Quake
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • The pluripotent state is first established in the primitive ectoderm cells of blastocysts but is progressively and irreversibly lost during development. For example, the transition from primitive ectoderm cell to epiblast cell, post implantation, involves significant transcriptional and epigenetic changes. A technique for reprogramming advanced epiblast cells from embryonic day 5.5–7.5 mouse embryos to embryonic-stem-cell-like cells — representing a return to pluripotency — is now demonstrated.

    • Siqin Bao
    • Fuchou Tang
    • M. Azim Surani
    Research
    Nature
    Volume: 461, P: 1292-1295

  • Together with a companion paper, the generation of a transcriptomic atlas for the mouse lemur and analyses of example cell types establish this animal as a molecularly tractable primate model organism.

    • Antoine de Morree
    • Iwijn De Vlaminck
    • Mark A. Krasnow
    ResearchOpen Access
    Nature
    Volume: 644, P: 173-184

  • Together with an accompanying paper presenting a transcriptomic atlas of the mouse lemur, interrogation of the atlas provides a rich body of data to support the use of the organism as a model for primate biology and health.

    • Camille Ezran
    • Shixuan Liu
    • Mark A. Krasnow
    ResearchOpen Access
    Nature
    Volume: 644, P: 185-196

  • Single-cell analysis of blood vessels in the alveolus, the site of chronic disease and virus-induced lung injury, reveals two intermingled endothelial cell types with specialized gas exchange and stem cell functions.

    • Astrid Gillich
    • Fan Zhang
    • Ross J. Metzger
    Research
    Nature
    Volume: 586, P: 785-789

  • Bin Zhou and colleagues use genetic labeling in mice to show that endocardial cells of the sinus venosus substantially contribute to the liver vasculature, which thus shares a common developmental origin with coronary arteries. Inhibition of endocardial angiogenesis leads to reduced endocardial contribution to the liver vasculature and to defects in liver organogenesis.

    • Hui Zhang
    • Wenjuan Pu
    • Bin Zhou
    Research
    Nature Genetics
    Volume: 48, P: 537-543

  • An integrated analysis of over 100 single-cell and single-nucleus transcriptomics studies illustrates severe acute respiratory syndrome coronavirus 2 viral entry gene coexpression patterns across different human tissues, and shows association of age, smoking status and sex with viral entry gene expression in respiratory cell populations.

    • Christoph Muus
    • Malte D. Luecken
    • Xiaohui Zhang
    Research
    Nature Medicine
    Volume: 27, P: 546-559

  • Endocrinologists have traditionally focused on studying one hormone or organ system at a time. Here the authors use transcriptomic data from the mouse lemur to globally characterize primate hormonal signaling, describing hormone sources and targets, identifying conserved and primate specific regulation, and elucidating principles of the network.

    • Shixuan Liu
    • Camille Ezran
    • James E. Ferrell Jr.
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-27

  • A transcriptomics study demonstrates cell-type-specific responses to differentially aged blood and shows young blood to have restorative and rejuvenating effects that may be invoked through enhanced mitochondrial function.

    • Róbert Pálovics
    • Andreas Keller
    • Tony Wyss-Coray
    Research
    Nature
    Volume: 603, P: 309-314

  • Bulk RNA sequencing of organs and plasma proteomics at different ages across the mouse lifespan is integrated with data from the Tabula Muris Senis, a transcriptomic atlas of ageing mouse tissues, to describe organ-specific changes in gene expression during ageing.

    • Nicholas Schaum
    • Benoit Lehallier
    • Tony Wyss-Coray
    Research
    Nature
    Volume: 583, P: 596-602