Nature Search

Structure and dynamics of the pyroglutamylated RF-amide peptide QRFP receptor GPR103

GPR103, a GPCR activated by pyroglutamylated RF-amide peptide QRFP, has various physiological functions, such as energy metabolism and appetite regulation. Here, the authors determined the cryoEM structure of the QRFP26- GPR103-Gq complex, revealing its peptide recognition mechanism.

Aika Iwama
Ryoji Kise
Osamu Nureki
ResearchOpen Access19 Jun 2024
Nature Communications

Volume: 15, P: 1-13
Hard magnetic ferrite with a gigantic coercivity and high frequency millimetre wave rotation

Permanent magnets based on magnetic ferrites such as Fe₃O₄ and Fe₂O₃ are used in a wide range of applications. This study demonstrates that introducing rhodium into nanoparticles consisting of the ε phase of Fe₂O₃gives rise to a very high coercivity.

Asuka Namai
Marie Yoshikiyo
Shin-ichi Ohkoshi
ResearchOpen Access04 Sept 2012
Nature Communications

Volume: 3, P: 1-6
Phase I/II trial of iPS-cell-derived dopaminergic cells for Parkinson’s disease

After transplantation into the brain of patients with Parkinson’s disease, allogeneic dopaminergic progenitors derived from induced pluripotent stem cells survived, produced dopamine and did not form tumours, therefore suggesting safety and potential clinical benefits for Parkinson’s disease.

Nobukatsu Sawamoto
Daisuke Doi
Jun Takahashi
ResearchOpen Access16 Apr 2025
Nature

Volume: 641, P: 971-977
Heteroduplex oligonucleotide technology boosts oligonucleotide splice switching activity of morpholino oligomers in a Duchenne muscular dystrophy mouse model

Here, the authors develop a PMO-based heteroduplex oligonucleotide technology that enhances PMO delivery to tissues and normalizes motor/cardiac function and CNS symptoms in a mouse model of Duchenne muscular dystrophy.

Juri Hasegawa
Tetsuya Nagata
Takanori Yokota
ResearchOpen Access26 Sept 2024
Nature Communications

Volume: 15, P: 1-15
Proteomic Dataset of Sparganum proliferum and Spirometra mansoni to Understand Asexual Proliferation in Hosts

Akito Fujihira
Kensei Kinoshita
Taisei Kikuchi
ResearchOpen Access10 Dec 2025
Scientific Data

Volume: 12, P: 1-8
Randomized study of two endo-knives for the traction-assisted endoscopic submucosal dissection of early esophageal squamous cell carcinoma

Yoshiyasu Kitagawa
Asuka Ishigaki
Takuto Suzuki
ResearchOpen Access17 Mar 2022
Scientific Reports

Volume: 12, P: 1-8
Validity, reliability, and user perspectives of the newly developed joint angle measurement system: a preliminary study

Taiki Yoshida
Shintaro Uehara
Yohei Otaka
ResearchOpen Access24 Nov 2025
Scientific Reports

Volume: 15, P: 1-10
Flattened 1D fragments of fullerene C₆₀ that exhibit robustness toward multi-electron reduction

Fullerenes are compelling molecular materials, but the reason for their high robustness to multi-electron reduction is still debated. Here, the authors synthesize flattened 1D fragments of fullerene C₆₀ with high robustness against multi-electron reduction.

Masahiro Hayakawa
Naoyuki Sunayama
Aiko Fukazawa
ResearchOpen Access15 May 2023
Nature Communications

Volume: 14, P: 1-12
Differences in stress response between two altitudes assessed by salivary cortisol levels within circadian rhythms in long-distance runners

Katsuhiko Tsunekawa
Kazumi Ushiki
Masami Murakami
ResearchOpen Access13 Jun 2022
Scientific Reports

Volume: 12, P: 1-9
Pre-clinical study of induced pluripotent stem cell-derived dopaminergic progenitor cells for Parkinson’s disease

Induced pluripotent stem cell (iPSC) derived dopaminergic neurons are a promising source for cell-based Parkinson’s disease (PD) therapy. Here the authors report a comprehensive pre-clinical evaluation of the safety and efficacy of dopaminergic progenitors derived from a clinical-grade human iPSC line.

Daisuke Doi
Hiroaki Magotani
Jun Takahashi
ResearchOpen Access06 Jul 2020
Nature Communications

Volume: 11, P: 1-14
A functional deficiency of TERA/VCP/p97 contributes to impaired DNA repair in multiple polyglutamine diseases

Mutations in polyglutamine proteins are implicated in neurodegenerative disorders. Okazawa and colleagues now demonstrate that mutant polyQ proteins interact directly with the ATPase TERA, resulting in reduced DNA double-strand break repair, which is a feature of neurodegenerative diseases.

Kyota Fujita
Yoko Nakamura
Hitoshi Okazawa
Research07 May 2013
Nature Communications

Volume: 4, P: 1-13
A novel efficient feeder-free culture system for the derivation of human induced pluripotent stem cells

Masato Nakagawa
Yukimasa Taniguchi
Shinya Yamanaka
ResearchOpen Access08 Jan 2014
Scientific Reports

Volume: 4, P: 1-7
Heterotrimeric Gq proteins act as a switch for GRK5/6 selectivity underlying β-arrestin transducer bias

GPCR kinases (GRKs) phosphorylate active-form G-protein-coupled receptors (GPCRs). Here, the authors reveal that Gq heterotrimer coupled with the angiotensin II type-1 receptor (AT1R) determines the GRK subtypes recruited to the complex in a microdomain, thus defining subsequent AT1R phosphorylation patterns, β-arrestin conformation and functionality.

Kouki Kawakami
Masataka Yanagawa
Asuka Inoue
ResearchOpen Access25 Jan 2022
Nature Communications

Volume: 13, P: 1-16
A more efficient method to generate integration-free human iPS cells

Human induced pluripotent stem cells are generated with episomal plasmid vectors at increased efficiency using non-transforming L-Myc and knockdown of p53. Also in this issue, Chen et al. report defined conditions for human cell reprogramming and culture.

Keisuke Okita
Yasuko Matsumura
Shinya Yamanaka
Research03 Apr 2011
Nature Methods

Volume: 8, P: 409-412
Comprehensive experimental datasets of quasicrystals and their approximants

Erina Fujita
Chang Liu
Yukari Katsura
ResearchOpen Access13 Nov 2024
Scientific Data

Volume: 11, P: 1-9
Localized fluid discharge by tensile cracking during the post-seismic period in subduction zones

Makoto Otsubo
Jeanne L. Hardebeck
Gaku Kimura
ResearchOpen Access03 Aug 2020
Scientific Reports

Volume: 10, P: 1-8
Nanometer-size hard magnetic ferrite exhibiting high optical-transparency and nonlinear optical-magnetoelectric effect

Shin-ichi Ohkoshi
Asuka Namai
Hiroko Tokoro
ResearchOpen Access06 Oct 2015
Scientific Reports

Volume: 5, P: 1-9
Orexin neurons play contrasting roles in itch and pain neural processing via projecting to the periaqueductal gray

The optogenetic approach sheds light on the diametric roles of ORX neurons in processing itch and pain. The neural circuit of ORX neurons from LH to the PAG region plays a crucial part in this bidirectional modulation of itch and pain processing.

Tatsuroh Kaneko
Asuka Oura
Hideki Kashiwadani
ResearchOpen Access08 Mar 2024
Communications Biology

Volume: 7, P: 1-12
Small non-coding RNAs have predicted roles in reproductive biology and transposable element regulation in the parasitic worm Strongyloides venezuelensis

Dominika Lastik
Asuka Kounosu
Taisei Kikuchi
ResearchOpen Access01 Jul 2025
Scientific Reports

Volume: 15, P: 1-16
Maternal immune activation followed by peripubertal stress combinedly produce reactive microglia and confine cerebellar cognition

Early developmental stress alters microglial function, linked to schizophrenia and autism. In a mouse model, inflammatory 2HIT stress increased cerebellar microglia and its turnover, causing Purkinje neuron loss and cerebellar dysfunction, which was improved by microglia replacement.

Momoka Hikosaka
Md Sorwer Alam Parvez
Gen Ohtsuki
ResearchOpen Access03 Mar 2025
Communications Biology

Volume: 8, P: 1-26
Differential brain volume between obese and underweight cognitively normal older adults with frailty in the JPSC-AD

Naoki Ishizuka
Hiroshi Akasaka
Yutaka Kiyohara
ResearchOpen Access04 Jun 2025
Scientific Reports

Volume: 15, P: 1-12
Profiling of runs of homozygosity from whole-genome sequence data in Japanese biobank

Aye Ko Ko Minn
Motomichi Matsuzaki
Gen Tamiya
ResearchOpen Access03 Apr 2025
Journal of Human Genetics

Volume: 70, P: 287-296
Structural insights into ligand recognition by the lysophosphatidic acid receptor LPA₆

Determination of the crystal structure of the zebrafish LPA₆ receptor shows that the lipid ligand binds to an unusual ligand-binding pocket in the receptor that is laterally accessible through the membrane.

Reiya Taniguchi
Asuka Inoue
Osamu Nureki
Research09 Aug 2017
Nature

Volume: 548, P: 356-360
New reference values for ultrasound fetal biometry in Japanese population and comparison with other studies

Sumito Nagasaki
Keisuke Ishii
Hirokazu Yorioka
ResearchOpen Access20 Aug 2025
Scientific Reports

Volume: 15, P: 1-12
piRNA-like small RNAs target transposable elements in a Clade IV parasitic nematode

Mona Suleiman
Asuka Kounosu
Vicky L. Hunt
ResearchOpen Access16 Jun 2022
Scientific Reports

Volume: 12, P: 1-17
Correlates of neutralizing/SARS-CoV-2-S1-binding antibody response with adverse effects and immune kinetics in BNT162b2-vaccinated individuals

Kenji Maeda
Masayuki Amano
Hiroaki Mitsuya
ResearchOpen Access24 Nov 2021
Scientific Reports

Volume: 11, P: 1-10
Draft genome of the brown alga, Nemacystus decipiens, Onna-1 strain: Fusion of genes involved in the sulfated fucan biosynthesis pathway

Koki Nishitsuji
Asuka Arimoto
Eiichi Shoguchi
ResearchOpen Access14 Mar 2019
Scientific Reports

Volume: 9, P: 1-11
Elevated β-catenin pathway as a novel target for patients with resistance to EGF receptor targeting drugs

Asuka Nakata
Ryo Yoshida
Noriko Gotoh
ResearchOpen Access13 Aug 2015
Scientific Reports

Volume: 5, P: 1-13
A Periodontal pathogen Porphyromonas gingivalis deteriorates Isoproterenol-Induced myocardial remodeling in mice

Hiroki Sato
Jun-ichi Suzuki
Yuichi Izumi
Research08 Sept 2016
Hypertension Research

Volume: 40, P: 35-40
Toll-like receptor-2 has a critical role in periodontal pathogen-induced myocardial fibrosis in the pressure-overloaded murine hearts

Makoto Kaneko
Jun-ichi Suzuki
Mitsuaki Isobe
Research01 Sept 2016
Hypertension Research

Volume: 40, P: 110-116
Correction: Corrigendum: Toll-like receptor-2 has a critical role in periodontal pathogen-induced myocardial fibrosis in the pressure-overloaded murine hearts

Makoto Kaneko
Jun-ichi Suzuki
Mitsuaki Isobe
Amendments and Corrections06 Feb 2017
Hypertension Research

Volume: 40, P: 212
Lymphocyte-to-monocyte ratio as a prognostic and potential tumor microenvironment indicator in advanced soft tissue sarcoma treated with first-line doxorubicin therapy

Sho Watanabe
Tatsunori Shimoi
Kan Yonemori
ResearchOpen Access03 Jul 2023
Scientific Reports

Volume: 13, P: 1-13
Identification of Gα₁₂-vs-Gα₁₃-coupling determinants and development of a Gα_12/13-coupled designer GPCR

Manae Tatsumi
Christian Cruz
Asuka Inoue
ResearchOpen Access15 May 2024
Scientific Reports

Volume: 14, P: 1-12
Influence of sipunculan (peanut worm) activity on orifice formation in scleractinian Heterocyathus for adaptation to soft substrates

Yuki Tokuda
Shuya Kawakita
Susumu Ohtsuka
ResearchOpen Access29 Apr 2024
Scientific Reports

Volume: 14, P: 1-14
Serum high-sensitivity C-reactive protein and dementia in a community-dwelling Japanese older population (JPSC-AD)

Ayumi Tachibana
Jun-ichi Iga
Yutaka Kiyohara
ResearchOpen Access28 Mar 2024
Scientific Reports

Volume: 14, P: 1-9
Simulating metabolic pathways to enhance interpretations of metabolome genome-wide association studies

Shun Kodate
Mitsuharu Sato
Kengo Kinoshita
ResearchOpen Access16 May 2025
Scientific Reports

Volume: 15, P: 1-11
Improved 18S and 28S rDNA primer sets for NGS-based parasite detection

Asuka Kounosu
Kazunori Murase
Taisei Kikuchi
ResearchOpen Access31 Oct 2019
Scientific Reports

Volume: 9, P: 1-12
Novel avian paramyxovirus-based vaccine vectors expressing the Ebola virus glycoprotein elicit mucosal and humoral immune responses in guinea pigs

Asuka Yoshida
Shin-Hee Kim
Siba K. Samal
ResearchOpen Access02 Apr 2019
Scientific Reports

Volume: 9, P: 1-10
Myotonic dystrophy type 1 patient-derived iPSCs for the investigation of CTG repeat instability

Junko Ueki
Masayuki Nakamori
Hidetoshi Sakurai
ResearchOpen Access13 Feb 2017
Scientific Reports

Volume: 7, P: 1-12
MicroRNA-302 switch to identify and eliminate undifferentiated human pluripotent stem cells

Callum J. C. Parr
Shota Katayama
Hirohide Saito
ResearchOpen Access09 Sept 2016
Scientific Reports

Volume: 6, P: 1-14
TIARP attenuates autoantibody-mediated arthritis via the suppression of neutrophil migration by reducing CXCL2/CXCR2 and IL-6 expression

Asuka Inoue
Isao Matsumoto
Takayuki Sumida
ResearchOpen Access20 Dec 2016
Scientific Reports

Volume: 6, P: 1-13
Discovery of an antibody for pan-ebolavirus therapy

Wakako Furuyama
Andrea Marzi
Ayato Takada
ResearchOpen Access10 Feb 2016
Scientific Reports

Volume: 6, P: 1-10
Periodontitis and myocardial hypertrophy

Jun-ichi Suzuki
Hiroki Sato
Issei Komuro
Reviews10 Nov 2016
Hypertension Research

Volume: 40, P: 324-328
Genome of the fatal tapeworm Sparganum proliferum uncovers mechanisms for cryptic life cycle and aberrant larval proliferation

Kikuchi et al. sequence the genome of the fatal tapeworm Sparganum proliferum and a closely related non–life-threatening tapeworm Spirometra erinaceieuropaei, and describe its genomic features suggesting the natural history and molecular mechanisms underlying pathogenicity. Their findings indicate that nonordinal extracellular matrix coordination is important for its asexual reproduction, and suggest that loss of sexual maturity contributes to the fatal pathogenicity of S. proliferum to humans.

Taisei Kikuchi
Mehmet Dayi
Haruhiko Maruyama
ResearchOpen Access31 May 2021
Communications Biology

Volume: 4, P: 1-12
Green tea consumption and cerebral white matter lesions in community-dwelling older adults without dementia

Shutaro Shibata
Moeko Noguchi-Shinohara
Yutaka Kiyohara
ResearchOpen Access07 Jan 2025
npj Science of Food

Volume: 9, P: 1-8
Hepatic tumor classification using texture and topology analysis of non-contrast-enhanced three-dimensional T1-weighted MR images with a radiomics approach

Asuka Oyama
Yasuaki Hiraoka
Jun’ichi Kotoku
ResearchOpen Access19 Jun 2019
Scientific Reports

Volume: 9, P: 1-10
Genetic profiles of Propionibacterium acnes and identification of a unique transposon with novel insertion sequences in sarcoid and non-sarcoid isolates

Kana Minegishi
Takayasu Watanabe
Yoshinobu Eishi
ResearchOpen Access12 May 2015
Scientific Reports

Volume: 5, P: 1-8
Glucose metabolism and smaller hippocampal volume in elderly people with normal cognitive function

Ayano Shima
Moeko Noguchi-Shinohara
Yutaka Kiyohara
ResearchOpen Access09 Sept 2024
npj Aging

Volume: 10, P: 1-10
Syntheses of methylated catechins and theaflavins using 2-nitrobenzenesulfonyl group to protect and deactivate phenol

Tomohiro Asakawa
Yusuke Kawabe
Toshiyuki Kan
Research24 Feb 2016
The Journal of Antibiotics

Volume: 69, P: 299-312

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