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Showing 1–13 of 13 results
Advanced filters: Author: Asya Rolls Clear advanced filters

  • How can you increase the success of hematopoietic stem cell (HSC) transplantation? In mice, Rolls et al. identify sleep in the donor as an important factor, finding that less sleep leads to 50% lower HSC engraftment, via miR-19b and suppressor of cytokine signaling genes, which prevent HSC homing.

    • Asya Rolls
    • Wendy W. Pang
    • Luis de Lecea
    Research
    Nature Communications
    Volume: 6, P: 1-9

  • Neural activation can have wide ranging effects beyond central and peripheral nervous system. This work shows that chemogenetic activation of the brain’s reward system ventral tegmental area (VTA) can boost mice’s immune function, confer anti-tumor immunity, and reduce tumor mass in experimental rodent models of lung carcinoma and melanoma.

    • Tamar L Ben-Shaanan
    • Maya Schiller
    • Asya Rolls
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-10

  • Haykin et al. show that activation of the brain’s reward system modulates adrenergic input to the liver and complement component 3 transcription, affecting vascularization and improving cardiac recovery after acute myocardial infarction.

    • H. Haykin
    • E. Avishai
    • A. Rolls
    Research
    Nature Cardiovascular Research
    Volume: 3, P: 841-856

  • The effects of the glial scar on regeneration after injury have traditionally been viewed as inhibitory. Schwartz and colleagues discuss the evidence that scar tissue can have a beneficial role in the repair process and propose that the timing of scar generation and degradation is crucial in determining its effects.

    • Asya Rolls
    • Ravid Shechter
    • Michal Schwartz
    Reviews
    Nature Reviews Neuroscience
    Volume: 10, P: 235-241

  • Chemogenetic activation of central nervous system reward circuitry in the mouse VTA is shown to strengthen immunological host defenses against subsequent bacterial exposure and infection.

    • Tamar L Ben-Shaanan
    • Hilla Azulay-Debby
    • Asya Rolls
    Research
    Nature Medicine
    Volume: 22, P: 940-944

  • In this Review, Rolls and colleagues discuss regulation of immune responses by the nervous system. The authors focus on the benefits of neuronal regulation of immunity, the mechanisms involved and the brain areas involved in neuro-immune crosstalk.

    • Maya Schiller
    • Tamar L. Ben-Shaanan
    • Asya Rolls
    Reviews
    Nature Reviews Immunology
    Volume: 21, P: 20-36

  • Korin et al. use CyTOF mass cytometry to characterize immune cell populations in the naive mouse brain (parenchyma, choroid plexus and meninges). This single-cell analysis of cell-surface proteins reveals the presence and phenotype of distinctive immune populations in the mouse brain compartment.

    • Ben Korin
    • Tamar L Ben-Shaanan
    • Asya Rolls
    Research
    Nature Neuroscience
    Volume: 20, P: 1300-1309

  • This protocol describes how to characterize immune cells in the mouse brain compartment using mass cytometry (CyTOF) and provides a step-by-step description from brain dissection to data analysis.

    • Ben Korin
    • Tania Dubovik
    • Asya Rolls
    Protocols
    Nature Protocols
    Volume: 13, P: 377-391