Nature Search

Geriatric nutritional risk index and newly developed scoring system as prognosis prediction for unresectable hepatocellular carcinoma patients treated with lenvatinib

Hideko Ohama
Atsushi Hiraoka
Takashi Kumada
ResearchOpen Access02 Jan 2025
Scientific Reports

Volume: 15, P: 1-11
Allogeneic iPSC-derived iNKT cells in recurrent head and neck cancer: a phase 1 trial

A first-in-human clinical trial of iPS cell-derived invariant natural killer T cells in patients with recurrent head and neck cancer demonstrated safety and early signs of efficacy, showing tumor growth suppression and activation of immune pathways.

Tomohisa Iinuma
Tomoya Kurokawa
Shinichiro Motohashi
ResearchOpen Access26 Nov 2025
Nature Communications

Volume: 16, P: 1-13
Associations of family history of hypertension, genetic, and lifestyle risks with incident hypertension

Masato Takase
Takumi Hirata
Masayuki Yamamoto
ResearchOpen Access13 Aug 2025
Hypertension Research

Volume: 48, P: 2606-2617
Direct reprogramming of human umbilical vein- and peripheral blood-derived endothelial cells into hepatic progenitor cells

The conditions to induce human hepatic progenitor cells from other cell types are unclear. Here, the authors reprogram human endothelial cells to hepatic progenitor cells by expressing FOXA3, HNF1A and HNF6, capable of giving rise to hepatocytes and cholangiocytes that reconstitute damaged liver tissues on transplantation.

Hiroki Inada
Miyako Udono
Atsushi Suzuki
ResearchOpen Access21 Oct 2020
Nature Communications

Volume: 11, P: 1-17
Correction: Corrigendum: Enhanced role of eddies in the Arctic marine biological pump

Eiji Watanabe
Jonaotaro Onodera
Michio J. Kishi
Amendments and Corrections30 Sept 2015
Nature Communications

Volume: 6, P: 1-3
Histone acetylation mediated by Brd1 is crucial for Cd8 gene activation during early thymocyte development

Regulation of CD4 and CD8 expression during thymic development is a classical model to study control of lineage determination. Here the authors show that Brd1 epigenetically marks CD8 enhancer for activation by mediating H3K14 acetylation, which is necessary for establishing the CD8 T-cell lineage.

Yuta Mishima
Changshan Wang
Atsushi Iwama
Research18 Dec 2014
Nature Communications

Volume: 5, P: 1-11
p53-inducible lncRNA LOC644656 causes genotoxic stress-induced stem cell maldifferentiation and cancer chemoresistance

The tumor suppressor p53 prevents malignant transformation and regulates stem cell function and differentiation. Here, the authors discover a p53-induced lncRNA, LOC644656, that regulates genotoxic stress-induced stem cell maldifferentiation and chemoresistance in cancer cells.

Ai Tamura
Kazuyuki Yamagata
Tomoaki Tanaka
ResearchOpen Access23 May 2025
Nature Communications

Volume: 16, P: 1-22
Enhanced role of eddies in the Arctic marine biological pump

Arctic sea ice has been in rapid decline in recent decades, yet the impact on biogeochemical cycling is unknown due to insufficient sampling. Watanabe et al.combine year-long mooring observations with numerical models to show that an eddy-induced biological pump would be enhanced by sea ice retreat.

Eiji Watanabe
Jonaotaro Onodera
Michio J. Kishi
ResearchOpen Access27 May 2014
Nature Communications

Volume: 5, P: 1-12
Inherited C-terminal TREX1 variants disrupt homology-directed repair to cause senescence and DNA damage phenotypes in Drosophila, mice, and humans

Variants of the 3′−5′ exonuclease TREX1 can cause retinal vasculopathy with cerebral leukoencephalopathy (RVCL). Here, the authors show that RVCL-associated TREX1 variants trigger DNA damage in humans, mice, and Drosophila, and render cells more vulnerable to DNA damage inducing agents.

Samuel D. Chauvin
Shoichiro Ando
Jonathan J. Miner
ResearchOpen Access01 Jun 2024
Nature Communications

Volume: 15, P: 1-23
Too much of a good thing

Maintenance of the peripheral naive CD8⁺ T cell pool depends on T cell antigen receptor (TCR) signals and interleukin 7 (IL-7). TCR signaling limits the duration of IL-7 signals to avoid an interferon-γ-mediated mechanism of apoptotic death of naive CD8⁺ T cells.

Atsushi Onodera
Damon John Tumes
Toshinori Nakayama
News & Views18 Jan 2013
Nature Immunology

Volume: 14, P: 112-114
Structural delineation and computational design of SARS-CoV-2-neutralizing antibodies against Omicron subvariants

In this study, the authors isolated SARS-CoV-2 receptor binding site monoclonal antibodies resistant to Omicron mutations. An amino acid in the receptor binding domain, tyrosine-489, is a virus-vulnerable site and a common footprint of broadly neutralizing antibodies.

Saya Moriyama
Yuki Anraku
Yoshimasa Takahashi
ResearchOpen Access14 Jul 2023
Nature Communications

Volume: 14, P: 1-17
Profiling of runs of homozygosity from whole-genome sequence data in Japanese biobank

Aye Ko Ko Minn
Motomichi Matsuzaki
Gen Tamiya
ResearchOpen Access03 Apr 2025
Journal of Human Genetics

Volume: 70, P: 287-296
Liver group 2 innate lymphoid cells regulate blood glucose levels through IL-13 signaling and suppression of gluconeogenesis

Besides hepatocytes, resident immune cells of the liver are also contributing to the body’s energy homeostasis. Here authors show that group 2 innate lymphoid cells interact with a specific set of hepatocytes in suppressing gluconeogenesis and regulate blood glucose levels via Interleukin-13 signalling.

Masanori Fujimoto
Masataka Yokoyama
Tomoaki Tanaka
ResearchOpen Access15 Sept 2022
Nature Communications

Volume: 13, P: 1-21
Hepatocytes differentiate into intestinal epithelial cells through a hybrid epithelial/mesenchymal cell state in culture

Hepatocytes dedifferentiate into progenitor-like cells in culture. Here, authors elucidate the dynamics and mechanisms of hepatocyte dedifferentiation and find an unexpected differentiation potential of hepatocytes into intestinal epithelial cells.

Shizuka Miura
Kenichi Horisawa
Atsushi Suzuki
ResearchOpen Access15 May 2024
Nature Communications

Volume: 15, P: 1-18
Serum C-reactive protein and albumin are useful biomarkers for tight control management of Crohn’s disease in Japan

Hisashi Shiga
Izuru Abe
Atsushi Masamune
ResearchOpen Access16 Jan 2020
Scientific Reports

Volume: 10, P: 1-8
ACC1 determines memory potential of individual CD4⁺ T cells by regulating de novo fatty acid biosynthesis

ACC1 is a rate-limiting enzyme during fatty acid biosynthesis. Here the authors describe how loss of ACC1 enhances CD4⁺ memory T cell formation and improves outcome in a murine model of parasite infection, indicating that lipid biosynthesis directs cell-fate determination during the generation of memory T cells.

Yusuke Endo
Atsushi Onodera
Toshinori Nakayama
Research14 Jan 2019
Nature Metabolism

Volume: 1, P: 261-275
CD103^hi T_reg cells constrain lung fibrosis induced by CD103^lo tissue-resident pathogenic CD4 T cells

Tissue-resident memory T cells (T_RM cells) are important for the localized protection of specific body compartments. Nakayama and colleagues identify heterogeneity in lung T_RM cells, with one subset driving fibrosis and inflammation and another reining in pathology in response to fungal challenge.

Tomomi Ichikawa
Kiyoshi Hirahara
Toshinori Nakayama
Research07 Oct 2019
Nature Immunology

Volume: 20, P: 1469-1480
Simulating metabolic pathways to enhance interpretations of metabolome genome-wide association studies

Shun Kodate
Mitsuharu Sato
Kengo Kinoshita
ResearchOpen Access16 May 2025
Scientific Reports

Volume: 15, P: 1-11
DUSP10 constrains innate IL-33-mediated cytokine production in ST2^hi memory-type pathogenic Th2 cells

T helper 2 (Th2) cells and type 2 innate lymphoid cells (ILC2) respond differently to interleukin-33 (IL-33) stimulation. Here the authors show that a phosphatase, Dusp10, is expressed in Th2, but not ILC2, to dephosphorylate p38 kinase, reduce GATA3 transcription factor activity, and suppress the induction of IL-5 in response to IL-33.

Takeshi Yamamoto
Yusuke Endo
Toshinori Nakayama
ResearchOpen Access12 Oct 2018
Nature Communications

Volume: 9, P: 1-15
The transcription factor Sox4 is a downstream target of signaling by the cytokine TGF-β and suppresses T_H2 differentiation

The mechanisms of TGF-β-mediated inhibition of T_H2 differentiation remain unclear. Nakayama and colleagues show that TGF-β induces the transcription factor Sox4, which negatively regulates the transcription factor GATA-3 by two independent mechanisms.

Makoto Kuwahara
Masakatsu Yamashita
Toshinori Nakayama
Research01 Jul 2012
Nature Immunology

Volume: 13, P: 778-786
Resequencing of the common marmoset genome improves genome assemblies and gene-coding sequence analysis

Kengo Sato
Yoko Kuroki
Yasubumi Sakakibara
ResearchOpen Access20 Nov 2015
Scientific Reports

Volume: 5, P: 1-8
Raf/MAPK and rapamycin-sensitive pathways mediate the anti-apoptotic function of p21Ras in IL-3-dependent hematopoietic cells

Taisei Kinoshita
Mikako Shirouzu
Atsushi Miyajima
Research07 Aug 1997
Oncogene

Volume: 15, P: 619-627
Blood pressure during long-term cilostazol-based dual antiplatelet therapy after stroke: a post hoc analysis of the CSPS.com trial

Kazunori Toyoda
Masatoshi Koga
Hiroaki Tanaka
ResearchOpen Access09 Jul 2024
Hypertension Research

Volume: 47, P: 2238-2249
Integrated molecular analysis of clear-cell renal cell carcinoma

Seishi Ogawa and colleagues report an integrated genomics analysis of more than 100 clear-cell renal carcinoma samples. They analyze whole genomes or exomes, RNA sequences and DNA methylation in ∼100 paired specimens and perform SNP array-based copy number analysis for 240 specimens. They identify new recurrently mutated pathways and new associations between DNA methylation, mutations, gene expression and copy number profiles.

Yusuke Sato
Tetsuichi Yoshizato
Seishi Ogawa
Research24 Jun 2013
Nature Genetics

Volume: 45, P: 860-867
Naphthacemycins, novel circumventors of β-lactam resistance in MRSA, produced by Streptomyces sp. KB-3346-5. I. The taxonomy of the producing strain, and the fermentation, isolation and antibacterial activities

Atsushi Fukumoto
Yong-Pil Kim
Kazuro Shiomi
Research15 Mar 2017
The Journal of Antibiotics

Volume: 70, P: 562-567
New reference values for ultrasound fetal biometry in Japanese population and comparison with other studies

Sumito Nagasaki
Keisuke Ishii
Hirokazu Yorioka
ResearchOpen Access20 Aug 2025
Scientific Reports

Volume: 15, P: 1-12
Palindromic amplification of the ERBB2 oncogene in primary HER2-positive breast tumors

Michael Marotta
Taku Onodera
Hisashi Tanaka
ResearchOpen Access17 Feb 2017
Scientific Reports

Volume: 7, P: 1-12
Influence of hospital capabilities and prehospital time on outcomes of thrombectomy for stroke in Japan from 2013 to 2016

Ai Kurogi
Daisuke Onozuka
Masayuki Yokota
ResearchOpen Access28 Feb 2022
Scientific Reports

Volume: 12, P: 1-17
Immunoglobulin subtype-coated bacteria are correlated with the disease activity of inflammatory bowel disease

Yutaro Masu
Yoshitake Kanazawa
Atsushi Masamune
ResearchOpen Access17 Aug 2021
Scientific Reports

Volume: 11, P: 1-12
Establishment of induced pluripotent stem cells from normal B cells and inducing AID expression in their differentiation into hematopoietic progenitor cells

Fumihiko Kawamura
Makoto Inaki
Akira Sakai
ResearchOpen Access10 May 2017
Scientific Reports

Volume: 7, P: 1-11
Transcription factor-mediated direct cellular reprogramming yields cell-type specific DNA methylation signature

Kenichi Horisawa
Shizuka Miura
Atsushi Suzuki
ResearchOpen Access15 Dec 2023
Scientific Reports

Volume: 13, P: 1-13
Anemia in Patients with Severe Aortic Stenosis

Kazuya Nagao
Tomohiko Taniguchi
Mitsuru Kitano
ResearchOpen Access13 Feb 2019
Scientific Reports

Volume: 9, P: 1-11
Asymptomatic versus Symptomatic Patients with Severe Aortic Stenosis

Norio Kanamori
Tomohiko Taniguchi
Mitsuru Kitano
ResearchOpen Access04 Jul 2018
Scientific Reports

Volume: 8, P: 1-10

Search

Geriatric nutritional risk index and newly developed scoring system as prognosis prediction for unresectable hepatocellular carcinoma patients treated with lenvatinib

Allogeneic iPSC-derived iNKT cells in recurrent head and neck cancer: a phase 1 trial

Associations of family history of hypertension, genetic, and lifestyle risks with incident hypertension

Direct reprogramming of human umbilical vein- and peripheral blood-derived endothelial cells into hepatic progenitor cells

Correction: Corrigendum: Enhanced role of eddies in the Arctic marine biological pump

Histone acetylation mediated by Brd1 is crucial for Cd8 gene activation during early thymocyte development

p53-inducible lncRNA LOC644656 causes genotoxic stress-induced stem cell maldifferentiation and cancer chemoresistance

Enhanced role of eddies in the Arctic marine biological pump

Inherited C-terminal TREX1 variants disrupt homology-directed repair to cause senescence and DNA damage phenotypes in Drosophila, mice, and humans

Too much of a good thing

Structural delineation and computational design of SARS-CoV-2-neutralizing antibodies against Omicron subvariants

Profiling of runs of homozygosity from whole-genome sequence data in Japanese biobank

Liver group 2 innate lymphoid cells regulate blood glucose levels through IL-13 signaling and suppression of gluconeogenesis

Hepatocytes differentiate into intestinal epithelial cells through a hybrid epithelial/mesenchymal cell state in culture

Serum C-reactive protein and albumin are useful biomarkers for tight control management of Crohn’s disease in Japan

ACC1 determines memory potential of individual CD4⁺ T cells by regulating de novo fatty acid biosynthesis

CD103^hi T_reg cells constrain lung fibrosis induced by CD103^lo tissue-resident pathogenic CD4 T cells

Simulating metabolic pathways to enhance interpretations of metabolome genome-wide association studies

DUSP10 constrains innate IL-33-mediated cytokine production in ST2^hi memory-type pathogenic Th2 cells

The transcription factor Sox4 is a downstream target of signaling by the cytokine TGF-β and suppresses T_H2 differentiation

Resequencing of the common marmoset genome improves genome assemblies and gene-coding sequence analysis

Raf/MAPK and rapamycin-sensitive pathways mediate the anti-apoptotic function of p21Ras in IL-3-dependent hematopoietic cells

Blood pressure during long-term cilostazol-based dual antiplatelet therapy after stroke: a post hoc analysis of the CSPS.com trial

Integrated molecular analysis of clear-cell renal cell carcinoma

Naphthacemycins, novel circumventors of β-lactam resistance in MRSA, produced by Streptomyces sp. KB-3346-5. I. The taxonomy of the producing strain, and the fermentation, isolation and antibacterial activities

New reference values for ultrasound fetal biometry in Japanese population and comparison with other studies

Palindromic amplification of the ERBB2 oncogene in primary HER2-positive breast tumors

Influence of hospital capabilities and prehospital time on outcomes of thrombectomy for stroke in Japan from 2013 to 2016

Immunoglobulin subtype-coated bacteria are correlated with the disease activity of inflammatory bowel disease

Establishment of induced pluripotent stem cells from normal B cells and inducing AID expression in their differentiation into hematopoietic progenitor cells

Transcription factor-mediated direct cellular reprogramming yields cell-type specific DNA methylation signature

Anemia in Patients with Severe Aortic Stenosis

Asymptomatic versus Symptomatic Patients with Severe Aortic Stenosis

Search

Quick links

Search

Filter By:

Search

Quick links