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Advanced filters: Author: Ava V. Papetti Clear advanced filters

A myeloid trisomy 21-associated gene variant is protective from Alzheimer’s disease

Engineering human microglia with a Down-syndrome-linked myeloid gene variant resists tau-induced dysfunction and protects neurons in chimeric brains, offering proof of concept for transformative microglial replacement therapies in Alzheimer’s disease.

Mengmeng Jin
Ziyuan Ma
Peng Jiang
Research24 Nov 2025
Nature Neuroscience

Volume: 29, P: 25-39
Deep phenotyping in 3q29 deletion syndrome: recommendations for clinical care

Rossana Sanchez Russo
Michael J. Gambello
Jennifer Gladys Mulle
ResearchOpen Access09 Feb 2021
Genetics in Medicine

Volume: 23, P: 872-880
Convergent and distributed effects of the 3q29 deletion on the human neural transcriptome

Esra Sefik
Ryan H. Purcell
Jennifer G. Mulle
ResearchOpen Access15 Jun 2021
Translational Psychiatry

Volume: 11, P: 1-14