Methods to access bicyclo[1.1.1]pentane building blocks are limited, with current routes requiring multiple steps. Now, a diverse array of bicyclo[1.1.1]pentane boronates can be accessed via a multi-component reaction in a single step. Alkyl, aryl and alkenyl substructures can be installed onto bicyclo[1.1.1]pentane boronates by the use of carboxylic acids and organohalides.
- Weizhe Dong
- Expédite Yen-Pon
- Gary A. Molander
