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Showing 1–7 of 7 results
Advanced filters: Author: Aydan Bulut-Karslioglu Clear advanced filters

  • The authors provide a suite of in vitro protocols through which mouse and human pluripotent stem cells, mouse blastocysts and human blastoids can be reversibly induced to enter a diapause-like dormant state via pharmacological inhibition of mTOR

    • Dhanur P. Iyer
    • Heidar Heidari Khoei
    • Aydan Bulut-Karslioglu
    Protocols
    Nature Protocols
    P: 1-28

  • van der Weijden et al. perform genomic, proteomic and metabolic analyses and find that FOXO1-mediated fatty acid oxidation maintains mouse embryos in diapause.

    • Vera A. van der Weijden
    • Maximilian Stötzel
    • Aydan Bulut-Karslioglu
    ResearchOpen Access
    Nature Cell Biology
    Volume: 26, P: 181-193

  • The mechanisms that initiate heterochromatin formation and maintain its distinction from euchromatin have remained elusive. However, a new study reveals a pathway in which transcriptional repression of pericentric repeats by sequence-specific transcription factors is essential for the integrity of heterochromatin, thereby considerably expanding the role of transcription factors beyond euchromatic gene regulation.

    • Aydan Bulut-Karslioglu
    • Valentina Perrera
    • Thomas Jenuwein
    Research
    Nature Structural & Molecular Biology
    Volume: 19, P: 1023-1030

  • Here the authors show that active DNA demethylation and transcription factor occupation at distal regulatory elements is essential for pluripotency maintenance in dormancy conditions.

    • Maximilian Stötzel
    • Chieh-Yu Cheng
    • Aydan Bulut-Karslioğlu
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 31, P: 1625-1639

  • The chromatin remodeler Chd1 mediates hypertranscription in embryonic stem (ES) cells and has been shown to associate with genes transcribed by RNA Polymerase (Pol) I and II. Here the authors provide mechanistic insights into this process and reveal that Chd1 is involved in protecting genome integrity at promoter regions by preventing DNA break accumulation.

    • Aydan Bulut-Karslioglu
    • Hu Jin
    • Miguel Ramalho-Santos
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-11

  • Inhibition of mechanistic target of rapamycin (mTOR) suspends mouse blastocyst development and the cells remain ‘paused’ in a reversible pluripotent state, allowing prolonged culture.

    • Aydan Bulut-Karslioglu
    • Steffen Biechele
    • Miguel Ramalho-Santos
    Research
    Nature
    Volume: 540, P: 119-123