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SMARCA4/2 loss reduces BCL-xL expression and confers a druggable MCL1 dependency in cancer

Jialin Jiang
Xianbing Zhu
Sidong Huang
ResearchOpen Access10 Mar 2026
npj Precision Oncology

P: 1-10
Neutrophil oxidative stress mediates obesity-associated vascular dysfunction and metastatic transmigration

Quail and colleagues demonstrate that neutrophil-derived ROS and extracellular traps (NETs) mediate breast cancer metastasis to the lungs by altering endothelial junctional adhesions, thus favoring vascular permeability and transendothelial migration of cancer cells.

Sheri A. C. McDowell
Robin B. E. Luo
Daniela F. Quail
Research03 May 2021
Nature Cancer

Volume: 2, P: 545-562
Exploring the prognostic significance of arm-level copy number alterations in triple-negative breast cancer

Samuel Doré
Mariam Ali
Logan A. Walsh
ResearchOpen Access14 May 2024
Oncogene

Volume: 43, P: 2015-2024

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SMARCA4/2 loss reduces BCL-xL expression and confers a druggable MCL1 dependency in cancer

Neutrophil oxidative stress mediates obesity-associated vascular dysfunction and metastatic transmigration

Exploring the prognostic significance of arm-level copy number alterations in triple-negative breast cancer

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