Membrane-adsorbed condensates are crucial for biomolecular localization and can induce significant changes in membrane morphology, but the underlying mechanisms remain underexplored. Here, the authors combine imaging experiments and coarse-grained simulations to study poly-Lysine/poly-Aspartate (K10/D10) coacervates with different unilamellar liposomes, showing that their membrane affinity can be tuned by the anionic lipid content and quantified through the intrinsic contact angle both in vitro and in silico.
- Sayantan Mondal
- Agustín Mangiarotti
- Qiang Cui
