Bacteria can infect tumour cells which may affect the biological characteristics of the tumour or even the therapeutic outcome. Here authors show that Stenotrophomonas, upon entering tumour cells, trigger endoplasmic reticulum stress, leading to STING degradation and inhibition of MHC-II+ macrophages, which ultimately cause tumour progression and immunotherapy resistance.
- Huolun Feng
- Kunling Chen
- Yong Li
