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Showing 1–4 of 4 results
Advanced filters: Author: Balvir Kunar Clear advanced filters

  • The kidney is vascularized with highly specialized and zonated endothelial cells that are essential for its filtration function. Here, Barry et al. provide a single-cell RNA sequencing analysis of the kidney vasculature that highlights its transcriptional heterogeneity and uncovers pathways important for its development and function.

    • David M. Barry
    • Elizabeth A. McMillan
    • Shahin Rafii
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14

  • The transient reactivation of ETV2 in adult human endothelial cells reprograms these cells to become adaptable vasculogenic endothelia that in three-dimensional matrices self-assemble into vascular networks that can transport blood and physiologically arborize organoids and decellularized tissues.

    • Brisa Palikuqi
    • Duc-Huy T. Nguyen
    • Shahin Rafii
    Research
    Nature
    Volume: 585, P: 426-432

  • Endothelial cells (ECs) are promising strategies to treat vasculopathies but little is known about the factors that sustain EC identity and govern functional integration into vasculature after transplantation. Here the authors show that Ets factors and Sox17 convert nonvascular cells to vascular cells with stable EC identity and function.

    • William Schachterle
    • Chaitanya R. Badwe
    • Shahin Rafii
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-12

  • The authors reprogram in vitro endothelial cells from adult mice into engraftable haematopoietic stem cells that display single-cell and multilineage properties, are capable of long-term self-renewal and can reconstitute T cell adaptive immune function.

    • Raphael Lis
    • Charles C. Karrasch
    • Shahin Rafii
    Research
    Nature
    Volume: 545, P: 439-445