Nature Search

cellSTAAR: incorporating single-cell-sequencing-based functional data to boost power in rare variant association testing of noncoding regions

cellSTAAR advances noncoding rare variant association analysis by integrating single-cell genomics data.

Eric Van Buren
Yi Zhang
Xihong Lin
Research31 Dec 2025
Nature Methods

P: 1-12
Programmable trans-splicing riboregulators for complex cellular logic computation

Scaling up genetic circuits is a longstanding challenge in synthetic biology. Here Gao et al. engineer split introns for programmable RNA-level gene regulation and integrate them with protein splicing for single-layer multi-input logic computation.

Yuanli Gao
Rizki Mardian
Baojun Wang
Research02 Jan 2025
Nature Chemical Biology

Volume: 21, P: 758-766
Northward rupture and early afterslip of two graben-bounding normal faults during the 2025 Dingri earthquake of Tibet

A wedge-shaped graben extension mechanism for the 2025 Dingri earthquake involved two graben-bounding faults, highlighting that early postseismic deformation is mainly driven by shallow afterslip and viscoelastic relaxation, with the afterslip spatially complementing coseismic slip, according to integration of field observations, geodetic and seismic data.

Wenbin Xu
Chengyuan Bai
Feng Shi
ResearchOpen Access26 Dec 2025
Communications Earth & Environment

Volume: 7, P: 1-12
Integrated metabolomic and transcriptomic analyses identify MYB genes regulating key metabolites and agronomic traits in upland cotton Gossypium hirsutum

A multiomics dataset including genomics, transcriptomics and metabolomic variations across 403 upland cotton accessions identifies MYB genes regulating key metabolites and agronomic traits during cotton ovule and fiber development.

Xiaomeng Zhang
Xinquan Tian
Xiongming Du
Research03 Nov 2025
Nature Genetics

Volume: 57, P: 2819-2830
Targeting STING elicits GSDMD-dependent pyroptosis and boosts anti-tumor immunity in renal cell carcinoma

Shengpan Wu
Baojun Wang
Xin Ma
Research04 Jan 2026
Oncogene

Volume: 45, P: 620-635
Reprogrammed tracrRNAs enable repurposing of RNAs as crRNAs and sequence-specific RNA biosensors

In type II CRISPR systems, the guide RNA (gRNA) comprises a CRISPR RNA (crRNA) and a hybridized trans-acting CRISPR RNA (tracrRNA), both being essential in guided DNA targeting functions. Here the authors investigate the programmability of crRNA-tracrRNA hybridization for Cas9 and apply this to biosensing.

Yang Liu
Filipe Pinto
Baojun Wang
ResearchOpen Access11 Apr 2022
Nature Communications

Volume: 13, P: 1-12
Quantifying the impact of heterogeneous particle distributions on riming in isolated mixed-phase cumulus clouds

Yunjia Qi
Xinlian Wu
Pengcheng Lin
ResearchOpen Access21 Nov 2025
npj Climate and Atmospheric Science

Volume: 8, P: 1-9
Engineered CRISPRa enables programmable eukaryote-like gene activation in bacteria

CRISPR activation strategies in bacteria are limited due to the reliance on σ⁷⁰ promoters. Here the authors demonstrate eukaryote-like gene activation with high dynamic ranges using σ⁵⁴- dependent promoters.

Yang Liu
Xinyi Wan
Baojun Wang
ResearchOpen Access26 Aug 2019
Nature Communications

Volume: 10, P: 1-16
Non-cell autonomous and spatiotemporal signalling from a tissue organizer orchestrates root vascular development

Cytokinin influences various aspects of plant growth and development, including vascular development. The TMO5/LHW complex regulates a precise balance of cytokinin in xylem and procambium, therefore organizing root vascular patterning in Arabidopsis.

BaoJun Yang
Max Minne
Bert De Rybel
Research15 Nov 2021
Nature Plants

Volume: 7, P: 1485-1494
Self-preservation strategy for approaching global warming targets in the post-Paris Agreement era

The emission allocation strategies of global scenarios do not specify the potential benefits from extra climate mitigation efforts. Here the authors show that compared to the current Nationally Distributed Contributions, the proposed self-preservation strategy might generate 126–616 trillion dollars of additional benefits by 2100.

Yi-Ming Wei
Rong Han
Zili Yang
ResearchOpen Access14 Apr 2020
Nature Communications

Volume: 11, P: 1-13
Validation of human telomere length multi-ancestry meta-analysis association signals identifies POP5 and KBTBD6 as human telomere length regulation genes

Here the authors conduct a multi-ancestry meta-analysis of telomere length, used diverse approaches to identify genes underlying association signals, and experimentally validated POP5 and KBTBD6 as regulators of telomere length in human cells.

Rebecca Keener
Surya B. Chhetri
Alexis Battle
ResearchOpen Access24 May 2024
Nature Communications

Volume: 15, P: 1-21
A Ce-CuZn catalyst with abundant Cu/Zn-O_V-Ce active sites for CO₂ hydrogenation to methanol

Carbon dioxide hydrogenation is an important industrial reaction. Here, the authors design a CeCuZn catalyst through a metal organic framework template for CO₂ hydrogenation to methanol with excellent methanol yield and stability.

Runping Ye
Lixuan Ma
Jian Liu
ResearchOpen Access09 Mar 2024
Nature Communications

Volume: 15, P: 1-14
A statistical framework for multi-trait rare variant analysis in large-scale whole-genome sequencing studies

MultiSTAAR provides a general and flexible statistical framework for functionally informed multi-trait rare variant analysis of biobank-scale sequencing studies by jointly analyzing multiple traits and incorporating annotation information.

Xihao Li
Han Chen
Xihong Lin
Research07 Feb 2025
Nature Computational Science

Volume: 5, P: 125-143
An expanded library of orthogonal split inteins enables modular multi-peptide assemblies

Inteins allow the joining of protein segments through scarless ligation. Here the authors assess 34 inteins to establish a library of 15 mutually orthogonal split inteins for in vivo applications, 10 of which are also active in vitro.

Filipe Pinto
Ella Lucille Thornton
Baojun Wang
ResearchOpen Access23 Mar 2020
Nature Communications

Volume: 11, P: 1-15
The therapeutic potential of Zuogui Wan in oligoasthenozoospermia: insights from network pharmacology, molecular docking, molecular dynamics simulation, and experimental validation

Mingzhao Zhang
Jisheng Wang
Xiao Li
ResearchOpen Access04 Nov 2025
Scientific Reports

Volume: 15, P: 1-22
Retraction Note: Targeting STING elicits GSDMD-dependent pyroptosis and boosts anti-tumor immunity in renal cell carcinoma

Shengpan Wu
Baojun Wang
Xin Ma
Amendments and Corrections08 Aug 2025
Oncogene

Volume: 44, P: 3154
Liquid biopsy-based single-cell metabolic phenotyping of lung cancer patients for informative diagnostics

Non-invasive methods to predict treatment response are urgently needed. Here in lung cancer, the authors develop a single-cell on-chip cytometry method to metabolically phenotype disseminated tumor cells, revealing metabolic heterogeneity and predictors of therapy response and survival.

Ziming Li
Zhuo Wang
Qihui Shi
ResearchOpen Access26 Aug 2019
Nature Communications

Volume: 10, P: 1-16
Dynamic monitoring of oscillatory enzyme activity of individual live bacteria via nanoplasmonic optical antennas

Nanoplasmonic antennas enable label-free monitoring of bacterial enzymes released via outer membrane vesicles. Real-time monitoring reveals the oscillatory behaviour of enzymatic release from individual bacteria as well as the effects of coupled oscillation from neighbouring bacteria.

Dengyun Lu
Guoshuai Zhu
Hongbao Xin
Research07 Aug 2023
Nature Photonics

Volume: 17, P: 904-911
Observation of full-parameter Jones matrix in bilayer metasurface

The realization of Jones matrix with full eight free parameters is particularly challenging. Here, the authors construct spatially varying Jones matrix with eight free parameters by cascading two-layer metasurfaces and use it for new optical functionalities.

Yanjun Bao
Fan Nan
Baojun Li
ResearchOpen Access07 Dec 2022
Nature Communications

Volume: 13, P: 1-8
Total glucosides of paeony ameliorates chemotherapy-induced neuropathic pain by suppressing microglia pyroptosis through the inhibition of KAT2A-mediated p38 pathway activation and succinylation

Rong Chen
Jiantao Hu
Baojun Min
ResearchOpen Access30 Dec 2024
Scientific Reports

Volume: 14, P: 1-11
Platelet-derived exosomal LINC00183 facilitate colorectal cancer malignant progression driven by histone lactylation through stabilizing ENO1

Guoqing Su
Jinghang Qian
Liu Yang
ResearchOpen Access07 Aug 2025
Cell Death & Disease

Volume: 16, P: 1-18
CCR2⁺ monocytes promote memory CD8⁺ T-cell differentiation via membrane-bound TGF-β

Lina Sun
Cangang Zhang
Baojun Zhang
Research03 Jun 2025
Cellular & Molecular Immunology

Volume: 22, P: 869-888
RETRACTED ARTICLE: Targeting STING elicits GSDMD-dependent pyroptosis and boosts anti-tumor immunity in renal cell carcinoma

Shengpan Wu
Baojun Wang
Xin Ma
Research28 Mar 2024
Oncogene

Volume: 43, P: 1534-1548
The chromosome-level genome assembly and annotation of the silver-lipped pearl oyster, Pinctada maxima

Qianqian Mu
Zijian Li
Pingping Liu
ResearchOpen Access26 Jul 2025
Scientific Data

Volume: 12, P: 1-8
FTO controls CD8⁺ T cell survival and effector response by modulating m⁶A methylation of Fas

Lina Sun
Tianzhe Zhang
Baojun Zhang
ResearchOpen Access15 Apr 2025
Cell Death & Disease

Volume: 16, P: 1-16
Single-cell biomagnifier for optical nanoscopes and nanotweezers

Yuchao Li
Xiaoshuai Liu
Baojun Li
ResearchOpen Access03 Jul 2019
Light: Science & Applications

Volume: 8, P: 1-12
Research on the comparison of impact resistance characteristics between energy absorption and conventional hydraulic columns in fluid–solid coupling

Jianzhuo Zhang
Hao Guo
Fengnian Zhao
ResearchOpen Access25 Nov 2023
Scientific Reports

Volume: 13, P: 1-20
Targeting a disintegrin and metalloprotease (ADAM) 17-CD122 axis enhances CD8⁺ T cell effector differentiation and anti-tumor immunity

Lina Sun
Anjun Jiao
Baojun Zhang
ResearchOpen Access26 Jun 2024
Signal Transduction and Targeted Therapy

Volume: 9, P: 1-15
circDYRK1A tethers biological behaviors of gastric carcinoma using novel bioinformatics analysis and experimental validations

Zirui Zhu
Huiwen Lu
Baojun Huang
ResearchOpen Access22 May 2023
Scientific Reports

Volume: 13, P: 1-15
Neural stimulation and modulation with sub-cellular precision by optomechanical bio-dart

We report a non-genetic optical neural stimulation and modulation strategy with sub-cellular precision based on optomechanical bio-dart, which also enables in vivo neural stimulation.

Guoshuai Zhu
Jianyun Xiong
Hongbao Xin
ResearchOpen Access19 Sept 2024
Light: Science & Applications

Volume: 13, P: 1-12
Inhibition of primary cilia-hedgehog signaling axis triggers autophagic cell death and suppresses malignant progression of VHL wild-type ccRCC

Shuo Tian
Songliang Du
Yan Huang
ResearchOpen Access10 Oct 2024
Cell Death & Disease

Volume: 15, P: 1-13
RETRACTED ARTICLE: Evolution of substrate-specific gene expression and RNA editing in brown rot wood-decaying fungi

Baojun Wu
Jill Gaskell
David S. Hibbett
Research04 Feb 2019
The ISME Journal

Volume: 13, P: 1391-1403
Synergistic and compensatory effects of two point mutations conferring target-site resistance to fipronil in the insect GABA receptor RDL

Yixi Zhang
Xiangkun Meng
Zewen Liu
ResearchOpen Access25 Aug 2016
Scientific Reports

Volume: 6, P: 1-11
PCaseek: ultraspecific urinary tumor DNA detection using deep learning for prostate cancer diagnosis and Gleason grading

Gaojie Li
Ye Wang
Weimin Ci
CorrespondenceOpen Access03 Sept 2024
Cell Discovery

Volume: 10, P: 1-3
MiR-708 promotes steroid-induced osteonecrosis of femoral head, suppresses osteogenic differentiation by targeting SMAD3

Cheng Hao
Shuhua Yang
Yong Feng
ResearchOpen Access02 Mar 2016
Scientific Reports

Volume: 6, P: 1-13
Genetic dissection of seed oil and protein content and identification of networks associated with oil content in Brassica napus

Hongbo Chao
Hao Wang
Maoteng Li
ResearchOpen Access10 Apr 2017
Scientific Reports

Volume: 7, P: 1-16
Bibliometrics and visualization analysis of literature on male hypogonadism from 2000 to 2023: research focus and frontiers

Jingyi Zhang
Yifeng Shen
Xujun Yu
Reviews05 Dec 2023
International Journal of Impotence Research

Volume: 36, P: 312-323

Search

cellSTAAR: incorporating single-cell-sequencing-based functional data to boost power in rare variant association testing of noncoding regions

Programmable trans-splicing riboregulators for complex cellular logic computation

Northward rupture and early afterslip of two graben-bounding normal faults during the 2025 Dingri earthquake of Tibet

Integrated metabolomic and transcriptomic analyses identify MYB genes regulating key metabolites and agronomic traits in upland cotton Gossypium hirsutum

Targeting STING elicits GSDMD-dependent pyroptosis and boosts anti-tumor immunity in renal cell carcinoma

Reprogrammed tracrRNAs enable repurposing of RNAs as crRNAs and sequence-specific RNA biosensors

Quantifying the impact of heterogeneous particle distributions on riming in isolated mixed-phase cumulus clouds

Engineered CRISPRa enables programmable eukaryote-like gene activation in bacteria

Non-cell autonomous and spatiotemporal signalling from a tissue organizer orchestrates root vascular development

Self-preservation strategy for approaching global warming targets in the post-Paris Agreement era

Validation of human telomere length multi-ancestry meta-analysis association signals identifies POP5 and KBTBD6 as human telomere length regulation genes

A Ce-CuZn catalyst with abundant Cu/Zn-O_V-Ce active sites for CO₂ hydrogenation to methanol

A statistical framework for multi-trait rare variant analysis in large-scale whole-genome sequencing studies

An expanded library of orthogonal split inteins enables modular multi-peptide assemblies

The therapeutic potential of Zuogui Wan in oligoasthenozoospermia: insights from network pharmacology, molecular docking, molecular dynamics simulation, and experimental validation

Retraction Note: Targeting STING elicits GSDMD-dependent pyroptosis and boosts anti-tumor immunity in renal cell carcinoma

Liquid biopsy-based single-cell metabolic phenotyping of lung cancer patients for informative diagnostics

Dynamic monitoring of oscillatory enzyme activity of individual live bacteria via nanoplasmonic optical antennas

Observation of full-parameter Jones matrix in bilayer metasurface

Total glucosides of paeony ameliorates chemotherapy-induced neuropathic pain by suppressing microglia pyroptosis through the inhibition of KAT2A-mediated p38 pathway activation and succinylation

Platelet-derived exosomal LINC00183 facilitate colorectal cancer malignant progression driven by histone lactylation through stabilizing ENO1

CCR2⁺ monocytes promote memory CD8⁺ T-cell differentiation via membrane-bound TGF-β

RETRACTED ARTICLE: Targeting STING elicits GSDMD-dependent pyroptosis and boosts anti-tumor immunity in renal cell carcinoma

The chromosome-level genome assembly and annotation of the silver-lipped pearl oyster, Pinctada maxima

FTO controls CD8⁺ T cell survival and effector response by modulating m⁶A methylation of Fas

Single-cell biomagnifier for optical nanoscopes and nanotweezers

Research on the comparison of impact resistance characteristics between energy absorption and conventional hydraulic columns in fluid–solid coupling

Targeting a disintegrin and metalloprotease (ADAM) 17-CD122 axis enhances CD8⁺ T cell effector differentiation and anti-tumor immunity

circDYRK1A tethers biological behaviors of gastric carcinoma using novel bioinformatics analysis and experimental validations

Neural stimulation and modulation with sub-cellular precision by optomechanical bio-dart

Inhibition of primary cilia-hedgehog signaling axis triggers autophagic cell death and suppresses malignant progression of VHL wild-type ccRCC

RETRACTED ARTICLE: Evolution of substrate-specific gene expression and RNA editing in brown rot wood-decaying fungi

Synergistic and compensatory effects of two point mutations conferring target-site resistance to fipronil in the insect GABA receptor RDL

PCaseek: ultraspecific urinary tumor DNA detection using deep learning for prostate cancer diagnosis and Gleason grading

MiR-708 promotes steroid-induced osteonecrosis of femoral head, suppresses osteogenic differentiation by targeting SMAD3

Genetic dissection of seed oil and protein content and identification of networks associated with oil content in Brassica napus

Bibliometrics and visualization analysis of literature on male hypogonadism from 2000 to 2023: research focus and frontiers

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