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Showing 1–13 of 13 results
Advanced filters: Author: Behnam Nabet Clear advanced filters

  • While EGFR tyrosine kinase inhibitors (TKIs) are often effective in EGFR mutant lung cancer, resistance often occurs. Here, the authors identify intratumoural heterogeneity of EGFR expression and find that EGFR-low cells are more tolerant to EGFR-TKI, promoting resistance.

    • Bassel Alsaed
    • Linh Lin
    • Heidi M. Haikala
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17

  • The dTAG system is used to rapidly deplete tagged target proteins in vitro and in vivo, but there are context- and protein-specific differences in its effectiveness. Here, the authors develop a second generation dTAG molecule that can degrade previously recalcitrant target proteins in cells and mice.

    • Behnam Nabet
    • Fleur M. Ferguson
    • Nathanael S. Gray
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-8

  • A highly selective inhibitor of the DCLK1/2 kinases is used to uncover the consequences of DCLK1 inhibition on viability, phosphosignaling and the transcriptome in patient-derived organoid models of pancreatic ductal adenocarcinoma.

    • Fleur M. Ferguson
    • Behnam Nabet
    • Nathanael S. Gray
    Research
    Nature Chemical Biology
    Volume: 16, P: 635-643

  • The dTAG system pairs potent heterobifunctional degraders and extensible tagging strategies to achieve immediate and reversible degradation of divergent proteins, facilitating biological investigation and drug target validation in cells and in mice.

    • Behnam Nabet
    • Justin M. Roberts
    • James E. Bradner
    Research
    Nature Chemical Biology
    Volume: 14, P: 431-441

  • A highly selective covalent peptide inhibitor of the peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 (Pin1) is used to show that Pin1 cooperates with mutant KRAS to promote pancreatic ductal adenocarcinoma (PDAC) transformation.

    • Benika J. Pinch
    • Zainab M. Doctor
    • Nathanael S. Gray
    Research
    Nature Chemical Biology
    Volume: 16, P: 979-987

  • The development of Sulfopin, a highly selective and potent, covalent Pin1 inhibitor that phenocopies Pin1 knockout and regresses tumors in murine and zebrafish models of neuroblastoma as well as in a pancreatic cancer mouse model.

    • Christian Dubiella
    • Benika J. Pinch
    • Nir London
    Research
    Nature Chemical Biology
    Volume: 17, P: 954-963

  • Analysis with alleles encoding pharmacologically degradable Mediator subunits shows that Mediator acts as a global coactivator that facilitates transcription globally but is acutely required for cell-type-specific gene regulatory circuits.

    • Martin G. Jaeger
    • Björn Schwalb
    • Georg E. Winter
    Research
    Nature Genetics
    Volume: 52, P: 719-727

  • This study reports a global analysis of binding sites for over 200 RNA-binding proteins (RBPs) from 24 species; conserved RNA-binding motifs are identified, and their analysis allows prediction of interaction sites based on the sequence of the RNA-binding domain alone.

    • Debashish Ray
    • Hilal Kazan
    • Timothy R. Hughes
    Research
    Nature
    Volume: 499, P: 172-177

  • This study investigates the effects of MYCN on the chromatin and transcriptional landscape of neuroblastoma. The authors find that, at oncogenic levels, MYCN binds to canonical E-boxes at promoters and invades enhancers, leading to transcriptional amplification.

    • Rhamy Zeid
    • Matthew A. Lawlor
    • James E. Bradner
    Research
    Nature Genetics
    Volume: 50, P: 515-523

  • ENL, identified in a genome-scale loss-of-function screen as a crucial requirement for proliferation of acute leukaemia, is required for leukaemic gene expression, and its YEATS chromatin-reader domain is essential for leukaemic growth.

    • Michael A. Erb
    • Thomas G. Scott
    • James E. Bradner
    Research
    Nature
    Volume: 543, P: 270-274