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Showing 1–8 of 8 results
Advanced filters: Author: Ben Sprangers Clear advanced filters

  • Here, the authors provide guidance on the prevention, diagnosis and management of anticancer therapy nephrotoxicity in adult patients. They also define a research agenda focused on preventing and mitigating anticancer therapy toxicity, maximizing early detection of nephrotoxicity and enabling optimal drug dosing in patients with kidney disease.

    • Amanda DeMauro Renaghan
    • Marlies Ostermann
    • Mitchell H. Rosner
    Reviews
    Nature Reviews Nephrology
    P: 1-18

  • The goal of allogeneic hematopoietic stem-cell transplantation (alloHSCT) in the treatment of hematological malignancies is to harness the graft-versus-leukemia (GVL) effect, while minimizing the risk of graft-versus-host disease (GVHD). AlloHSCT research has focused on the GVL target antigens and effector mechanisms, and on potential approaches to exploit the GVL effect independently of GVHD. In this review, the authors focus on the currently available approaches to exploit these GVL mechanisms and discuss some of the newer approaches that have been explored in clinical practice.

    • Ben Sprangers
    • Bart Van Wijmeersch
    • An D Billiau
    Reviews
    Nature Clinical Practice Oncology
    Volume: 4, P: 404-414

  • Membranous nephropathy (MN) is a rare autoimmune disease of podocyte-directed antibodies, such as anti-phospholipase A2 receptor. Here, the authors report a genome-wide association study for MN and identify two previously unreported loci encompassing the NFKB1 and IRF4 genes and additional ancestry-specific effects.

    • Jingyuan Xie
    • Lili Liu
    • Krzysztof Kiryluk
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-18

  • Flares of systemic lupus erythematosus are broadly defined as an increase in disease activity requiring an intensification of therapy. A renal flare is indicated by an increase in proteinuria and/or serum creatinine concentration, abnormal urine sediment or a reduction in creatinine clearance rate as a result of active disease. In this Review the authors examine current definitions of renal flares and describe developments in the diagnosis and treatment of renal flares.

    • Ben Sprangers
    • Marianne Monahan
    • Gerald B. Appel
    Reviews
    Nature Reviews Nephrology
    Volume: 8, P: 709-717

  • Although long-term kidney allograft failure is broadly classified as T cell- or antibody-mediated, this dichotomy is not always apparent in all patients, highlighting the need for improved allograft tissue characterisation. Here, the authors use single-cell RNA sequencing and multiplex imaging for transcriptomic and spatial profiling of allograft tissue from patients experiencing different degrees of rejection severity.

    • Baptiste Lamarthée
    • Jasper Callemeyn
    • Maarten Naesens
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-22

  • Immune checkpoint inhibitors are increasingly used as anti-cancer treatments; however, their use can be associated with the development of immune-related adverse events, including acute kidney injury. This Review describes the symptoms, biochemical signs and possible underlying mechanisms of immune checkpoint inhibitor-associated acute kidney injury, and proposes an approach to its diagnosis and management.

    • Ben Sprangers
    • David E. Leaf
    • Mark A. Perazella
    Reviews
    Nature Reviews Nephrology
    Volume: 18, P: 794-805