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Showing 1–6 of 6 results
Advanced filters: Author: Benjamin Sivyer Clear advanced filters

  • How do dendrites contribute to neuronal computations in intact circuits? Using dual whole-cell recordings from the soma and dendrites of retinal ganglion cells, Sivyer and Williams demonstrate that the engagement and inhibitory synaptic control of a cascade of active dendritic integration compartments underlies the computation of image motion by direction-selective rabbit retinal ganglion cells—placing dendritic integration at the heart of physiologically engaged neuronal-circuit operation.

    • Benjamin Sivyer
    • Stephen R Williams
    Research
    Nature Neuroscience
    Volume: 16, P: 1848-1856

  • The inability of intrinsically photosensitive retinal ganglion cells to shift the circadian clock in the suprachiasmatic nucleus during daytime is caused by light-dependent depolarization block of these cells.

    • Ruchi Komal
    • Corinne Beier
    • Samer Hattar
    Research
    Nature
    Volume: 650, P: 942-950

  • The mechanisms that trigger neurodegeneration in demyelinating disease are unclear. Here, the authors find that impaired remyelination induces a DLK-mediated loss of retinal ganglion cells (RGCs), and that efficient remyelination or DLK inhibition block RGC death.

    • Greg J. Duncan
    • Sam D. Ingram
    • Ben Emery
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-19

  • Activating the spared neurons downstream of rods and cones is a potential therapeutic approach for retinal degeneration, but has been limited by the characteristics of the opsins available. Here, the authors use medium wavelength cone opsin which has faster kinetics than others and show that it resolves some of these difficulties in a mouse model.

    • Michael H. Berry
    • Amy Holt
    • Ehud Y. Isacoff
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12

  • Processing within neural circuits in the retina extracts information about the direction of motion of images projected onto the retina. Vaney and colleagues describe the cellular components of this circuitry and outline our current understanding of the mechanisms that are involved in generating direction-selective responses in the retina.

    • David I. Vaney
    • Benjamin Sivyer
    • W. Rowland Taylor
    Reviews
    Nature Reviews Neuroscience
    Volume: 13, P: 194-208