The role of cellular prion protein (PrP) during CMV infection in newborns is not entirely clear. Here, the authors show that CMV-induced PrP release mediated by ADAM10 shedding impairs the neonatal antiviral response in mice by compromising CD8 T-cells leading to higher viral titers and more severe disease outcome.
- Dubravka Karner
- Daria Kvestak
- Tihana Lenac Rovis
