Targeted Protein Degradation (TPD) relies on the binding of specific targets and E3 ubiquitin-ligases to promote ubiquitination and degradation of targets by the proteasome. Here, by designing chimeras that bind the proteasome-associated factor Usp14, the authors present a generalizable TPD approach based on proteasome-dependent and E3 ligase-independent small-molecule compounds.
- Mireia Casasampere
- Hector Carneros
- Bernat Crosas
