Nature Search

Selective optogenetic control of G_q signaling using human Neuropsin

Gq proteins are one of four major classes of G proteins; optogenetic receptors for selective and repetitive activation of Gq proteins with fast kinetics are lacking. Here the authors report UV light-dependent Gq signalling using human Neuropsin (hOPN5) and demonstrate its potential as an optogenetic tool.

Ahmed Wagdi
Daniela Malan
Tobias Bruegmann
ResearchOpen Access01 Apr 2022
Nature Communications

Volume: 13, P: 1-18
Integrating sequence and array data to create an improved 1000 Genomes Project haplotype reference panel

1000 Genomes imputation can increase the power of genome-wide association studies to detect genetic variants associated with human traits and diseases. Here, the authors develop a method to integrate and analyse low-coverage sequence data and SNP array data, and show that it improves imputation performance.

Olivier Delaneau
Jonathan Marchini
Leena Peltonenz
Research13 Jun 2014
Nature Communications

Volume: 5, P: 1-9
Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses

Genome-wide analysis identifies 32 loci associated with breast cancer susceptibility, accounting for estrogen receptor, progesterone receptor and human epidermal growth factor receptor 2 status and tumor grade.

Haoyu Zhang
Thomas U. Ahearn
Montserrat García-Closas
Research18 May 2020
Nature Genetics

Volume: 52, P: 572-581
Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins

Wollscheid et al. describe a multiplexed, mass spectrometry–based approach to catalog glycoproteins on the surfaces of live cells without the need for antibodies. They use it to monitor changes in the cell-surface glycoproteome during T-cell activation and the differentiation of embryonic stem cells to neural progenitors.

Bernd Wollscheid
Damaris Bausch-Fluck
Julian D Watts
Research06 Apr 2009
Nature Biotechnology

Volume: 27, P: 378-386
Trophic dynamics and metabolic pathways in host parasite interactions revealed by nitrogen isotope analysis of amino acids in multiple tissues

Shaista Khaliq
Milen Nachev
Torsten C. Schmidt
ResearchOpen Access18 Sept 2025
Scientific Reports

Volume: 15, P: 1-15
Vascular normalization in Rgs5-deficient tumours promotes immune destruction

RGS5, a signalling protein that regulates the activity of G proteins, is shown to be an important regulator of the tumour vasculature. Deletion of RGS5 leads to normalization of blood vessels of tumours, making them less leady and improving their coverage with pericytes. As a consequence, more immune cells that can target the tumour cells reach the tumour, which enhances the survival of tumour-bearing mice.

Juliana Hamzah
Manfred Jugold
Ruth Ganss
Research16 Apr 2008
Nature

Volume: 453, P: 410-414
A global reference for human genetic variation

Results for the final phase of the 1000 Genomes Project are presented including whole-genome sequencing, targeted exome sequencing, and genotyping on high-density SNP arrays for 2,504 individuals across 26 populations, providing a global reference data set to support biomedical genetics.

Adam Auton
Gonçalo R. Abecasis
Gonçalo R. Abecasis
ResearchOpen Access30 Sept 2015
Nature

Volume: 526, P: 68-74
Attractive and repulsive Fermi polarons in two dimensions

Investigations of a two-dimensional spin-imbalanced Fermi gas reveal the existence of the Fermi polaron for attractive and repulsive interactions, and the transition from the attractive polaron to a molecule.

Marco Koschorreck
Daniel Pertot
Michael Köhl
Research23 May 2012
Nature

Volume: 485, P: 619-622
A Biotechnological Method Provides Access to Aggregation Competent Monomeric Alzheimer's 1–42 Residue Amyloid Peptide

Heinz Döbeli
Nicholas Draeger
Martin Zulauf
Research01 Sept 1995
Bio/Technology

Volume: 13, P: 988-993
Blunted ventral striatal responses to anticipated rewards foreshadow problematic drug use in novelty-seeking adolescents

Some adolescents seek novelty, but it is unknown whether the brain circuits underlying this behaviour can be used to predict later, problematic behaviour. Here, authors show that diminished ventral striatal and prefrontal activity in response to anticipated rewards at age 14 in these individuals predicts problematic drug use at age 16.

Christian Büchel
Jan Peters
Veronika Ziesch
ResearchOpen Access21 Feb 2017
Nature Communications

Volume: 8, P: 1-11
Martian dust storm impact on atmospheric H₂O and D/H observed by ExoMars Trace Gas Orbiter

High-resolution measurements of Martian atmospheric dust, water and semiheavy water, obtained by the ExoMars Trace Gas Orbiter during a global dust storm on Mars, are reported.

Ann Carine Vandaele
Oleg Korablev
Maria Paz Zorzano
Research10 Apr 2019
Nature

Volume: 568, P: 521-525
Cardiac troponin T and echocardiographic dimensions after repeated sprint vs. moderate intensity continuous exercise in healthy young males

Matthias Weippert
Dimitar Divchev
Christoph A. Nienaber
ResearchOpen Access19 Apr 2016
Scientific Reports

Volume: 6, P: 1-7
Chiral magnetoresistance in the Weyl semimetal NbP

Anna Corinna Niemann
Johannes Gooth
Kornelius Nielsch
ResearchOpen Access06 Mar 2017
Scientific Reports

Volume: 7, P: 1-6
Experimental signatures of the mixed axial–gravitational anomaly in the Weyl semimetal NbP

A positive magneto-thermoelectric conductance is observed in the Weyl semimetal niobium phosphide, suggesting the presence of the elusive mixed axial–gravitational anomaly.

Johannes Gooth
Anna C. Niemann
Kornelius Nielsch
Research20 Jul 2017
Nature

Volume: 547, P: 324-327
Establishing and validating syndromic surveillance of gastrointestinal infections using routine emergency department data, Germany, 2019–2023

Jonathan Hans Josef Baum
Achim Dörre
Madlen Schranz
ResearchOpen Access03 Nov 2025
Scientific Reports

Volume: 15, P: 1-10
Engineered Fv Fragments as a Tool for the One-Step Purification of Integral Multisubunit Membrane Protein Complexes

Gerald Kleymann
Christian Ostermeier
Hartmut Michel
Research01 Feb 1995
Bio/Technology

Volume: 13, P: 155-160
Allogeneic transplantation in multiple myeloma: long-term follow-up and cytogenetic subgroup analysis

Stefan Knop
Monika Engelhardt
M. Svaldi
Research28 Aug 2019
Leukemia

Volume: 33, P: 2710-2719
Common genetic variants influence human subcortical brain structures

Genome-wide association studies are used to identify common genetic variants that affect the structure of selected subcortical regions of the human brain; their identification provides insight into the causes of variability in brain development and may help to determine mechanisms of neuropsychiatric dysfunction.

Derrek P. Hibar
Jason L. Stein
Sarah E. Medland
Research21 Jan 2015
Nature

Volume: 520, P: 224-229
Immune-mediated neuropathies

This Primer discusses the epidemiology, mechanisms, differential diagnosis and management of the immune-mediated neuropathies — a large group of disorders that includes Guillain–Barré syndrome, chronic inflammatory demyelinating polyradiculoneuropathy and multifocal motor neuropathy, among other disorders.

Bernd C. Kieseier
Emily K. Mathey
Hans-Peter Hartung
Reviews11 Oct 2018
Nature Reviews Disease Primers

Volume: 4, P: 1-23
Therapy-induced senescence of glioblastoma cells is determined by the p21^CIP1-CDK1/2 axis and does not require activation of DREAM

Christian Schwarzenbach
Justus Rinke
Markus Christmann
ResearchOpen Access03 May 2025
Cell Death & Disease

Volume: 16, P: 1-12
The genome of the recently domesticated crop plant sugar beet (Beta vulgaris)

A full genome sequence is presented of sugar beet Beta vulgaris, the first plant belonging to Caryophyllales to have its genome sequenced; spinach was sequenced to enable inter-clade comparisons, and intraspecific variation was analysed by comparative genomics of a progenitor of all beet crops and additional sugar beet accessions.

Juliane C. Dohm
André E. Minoche
Heinz Himmelbauer
ResearchOpen Access18 Dec 2013
Nature

Volume: 505, P: 546-549
Comparative proteomics reveals unexpected quantitative phosphorylation differences linked to platelet activation state

G. J. Schmidt
C. M. Reumiller
M. Zellner
ResearchOpen Access12 Dec 2019
Scientific Reports

Volume: 9, P: 1-16
Aggregation of type-2 diabetes, prediabetes, and metabolic syndrome in German couples

Lara Brieger
Sara Schramm
Bernd Kowall
ResearchOpen Access05 Feb 2024
Scientific Reports

Volume: 14, P: 1-10
Mutations in PYCR1 cause cutis laxa with progeroid features

Stefan Mundlos and colleagues report the identification of mutations in PYCR1 that cause autosomal recessive cutis laxa. PYCR1 encodes an enzyme involved in proline metabolism and localizes to mitochondria.

Bruno Reversade
Nathalie Escande-Beillard
Uwe Kornak
Research02 Aug 2009
Nature Genetics

Volume: 41, P: 1016-1021
Unlocking the potential of the terrestrial gastropod species Zootecus insularis as a climate archive for arid regions

Katharina E. Schmitt
Lucas Proctor
Bernd R. Schöne
ResearchOpen Access21 Apr 2025
Scientific Reports

Volume: 15, P: 1-13
Macromolecular organic compounds from the depths of Enceladus

The detection of complex organic molecules with masses higher than 200 atomic mass units in ice grains emitted from Enceladus indicates the presence of a thin organic-rich layer on top of the moon’s subsurface ocean.

Frank Postberg
Nozair Khawaja
J. Hunter Waite
Research27 Jun 2018
Nature

Volume: 558, P: 564-568
Familial cleft tongue caused by a unique translation initiation codon variant in TP63

Julia Schmidt
Gudrun Schreiber
Bernd Wollnik
ResearchOpen Access11 Oct 2021
European Journal of Human Genetics

Volume: 30, P: 211-218
A novel single-cell RNA-sequencing approach and its applicability connecting genotype to phenotype in ageing disease

Orr Shomroni
Maren Sitte
Gabriela Salinas
ResearchOpen Access08 Mar 2022
Scientific Reports

Volume: 12, P: 1-14
Through-bond and through-space radiofrequency amplification by stimulated emission of radiation

Radio Amplification by Stimulated Emission of Radiation (RASER) may produce very narrow NMR lines, background-free NMR spectroscopy, and excitation-free sensing of chemical transformations. Here, the authors show that pairwise addition of parahydrogen to various propargylic compounds induces RASER activity of other protons beyond those chemically introduced in the reaction via through-bond or through-space interactions.

Ivan A. Trofimov
Oleg G. Salnikov
Igor V. Koptyug
ResearchOpen Access16 Oct 2024
Communications Chemistry

Volume: 7, P: 1-9
Rapid in situ carbon-13 hyperpolarization and imaging of acetate and pyruvate esters without external polarizer

Hyperpolarized ¹³C MRI visualizes real-time metabolic processes in vivo, however, external polarizers are commonly required to produce hyperpolarized metabolites. Here, using a parahydrogen-based approach, the authors achieved up to 30% ¹³C polarization in situ in an MRI system for precursor molecules [1-¹³C]acetate and [1-¹³C]pyruvate ethyl esters in their perdeuterated forms, potentially facilitating future metabolic imaging applications.

Obaid Mohiuddin
Henri de Maissin
Andreas B. Schmidt
ResearchOpen Access23 Oct 2024
Communications Chemistry

Volume: 7, P: 1-9
How context alters value: The brain’s valuation and affective regulation system link price cues to experienced taste pleasantness

Liane Schmidt
Vasilisa Skvortsova
Hilke Plassmann
ResearchOpen Access14 Aug 2017
Scientific Reports

Volume: 7, P: 1-13
Large-scale assessment of physical activity in a population using high-resolution hip-worn accelerometry: the German National Cohort (NAKO)

Andrea Weber
Vincent T. van Hees
Hansjörg Baurecht
ResearchOpen Access04 Apr 2024
Scientific Reports

Volume: 14, P: 1-13
Neuropsychosocial profiles of current and future adolescent alcohol misusers

Many factors have been proposed as contributors to risk of alcohol abuse, but quantifying their influence has been difficult; here a longitudinal study of a large sample of adolescents and machine learning are used to generate models of predictors of current and future alcohol abuse, assessing the relative contribution of many factors, including life history, individual personality differences, brain structure and genotype.

Robert Whelan
Richard Watts
Veronika Ziesch.
Research02 Jul 2014
Nature

Volume: 512, P: 185-189
Genome-wide association study of germline variants and breast cancer-specific mortality

Maria Escala-Garcia
Qi Guo
Marjanka K. Schmidt
ResearchOpen Access21 Feb 2019
British Journal of Cancer

Volume: 120, P: 647-657
Associations between self-reported sleep characteristics and incident mild cognitive impairment: The Heinz Nixdorf Recall Cohort Study

Christian Brachem
Angela Winkler
Martha Jokisch
ResearchOpen Access16 Apr 2020
Scientific Reports

Volume: 10, P: 1-12
The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer

Gisella Figlioli
Massimo Bogliolo
Paolo Peterlongo
ResearchOpen Access01 Nov 2019
npj Breast Cancer

Volume: 5, P: 1-14
Monitoring underwater volcano degassing using fiber-optic sensing

Corentin Caudron
Yaolin Miao
Torsten Dahm
ResearchOpen Access07 Feb 2024
Scientific Reports

Volume: 14, P: 1-12
The association between frailty and MRI features of cerebral small vessel disease

Ilse M. J. Kant
Henri J. M. M. Mutsaerts
Norman Zacharias
ResearchOpen Access05 Aug 2019
Scientific Reports

Volume: 9, P: 1-9
Epidemiology of 7375 children and adolescents hospitalized with COVID-19 in Germany, reported via a prospective, nationwide surveillance study in 2020–2022

Maren Doenhardt
Markus Hufnagel
Ulrich Zügge
ResearchOpen Access02 Jan 2024
Scientific Reports

Volume: 14, P: 1-15
Tg1.4HBV-s-rec mice, a crossbred hepatitis B virus-transgenic model, develop mild hepatitis

Stefan Schefczyk
Xufeng Luo
Ruth Broering
ResearchOpen Access20 Dec 2023
Scientific Reports

Volume: 13, P: 1-14
No detection of methane on Mars from early ExoMars Trace Gas Orbiter observations

Highly sensitive measurements of the atmosphere of Mars with the ExoMars Trace Gas Orbiter do not detect any methane over a range of latitudes in both hemispheres, in contrast to previous local or remote detections.

Oleg Korablev
Ann Carine Vandaele
Maria Paz Zorzano
Research10 Apr 2019
Nature

Volume: 568, P: 517-520
Differential predictors for alcohol use in adolescents as a function of familial risk

Mira Tschorn
Robert C. Lorenz
Amir Tahmasebi
ResearchOpen Access04 Mar 2021
Translational Psychiatry

Volume: 11, P: 1-11
Synergism between coexisting eye diseases and sex in increasing the prevalence of the dry eye syndrome

Andreas Stang
Börge Schmidt
Gerd Geerling
ResearchOpen Access03 Jan 2024
Scientific Reports

Volume: 14, P: 1-9
Quasi-continuous production of highly hyperpolarized carbon-13 contrast agents every 15 seconds within an MRI system

Magnetic resonance imaging of hyperpolarized contrast agents has enabled unprecedented imaging capabilities in a biomedical setting, but its widespread application is hindered by the time and costs associated with preparing hyperpolarized carbon-13 samples. Here, the authors demonstrate virtually-continuous production of batches of highly-hyperpolarized carbon-13 contrast agents every 15 s within an MRI system without a stand-alone polarizer.

Andreas B. Schmidt
Mirko Zimmermann
Jan-Bernd Hövener
ResearchOpen Access18 Feb 2022
Communications Chemistry

Volume: 5, P: 1-7
Larix species range dynamics in Siberia since the Last Glacial captured from sedimentary ancient DNA

Using ancient sedimentary DNA from up to 50 kya, dramatic distributional shifts are documented in two dominant boreal larch species, likely guided by environmental changes suggesting climate as a strong determinant of species distribution.

Luise Schulte
Stefano Meucci
Ulrike Herzschuh
ResearchOpen Access09 Jun 2022
Communications Biology

Volume: 5, P: 1-11
A new technique to study nutrient flow in host-parasite systems by carbon stable isotope analysis of amino acids and glucose

Tobias Hesse
Milen Nachev
Torsten C. Schmidt
ResearchOpen Access19 Jan 2023
Scientific Reports

Volume: 13, P: 1-11
MR-orthopantomography in operative dentistry and oral and maxillofacial surgery: a proof of concept study

Adib Al-Haj Husain
Valérie Schmidt
Marco Piccirelli
ResearchOpen Access17 Apr 2023
Scientific Reports

Volume: 13, P: 1-12
E-cadherin breast tumor expression, risk factors and survival: Pooled analysis of 5,933 cases from 12 studies in the Breast Cancer Association Consortium

Hisani N. Horne
Hannah Oh
Jonine D. Figueroa
ResearchOpen Access26 Apr 2018
Scientific Reports

Volume: 8, P: 1-11
Insights into amino acid fractionation and incorporation by compound-specific carbon isotope analysis of three-spined sticklebacks

Tobias Hesse
Milen Nachev
Torsten C. Schmidt
ResearchOpen Access08 Jul 2022
Scientific Reports

Volume: 12, P: 1-11
Amplifications of the epidermal growth factor receptor gene (egfr) are common in phyllodes tumors of the breast and are associated with tumor progression

Christian Kersting
Arno Kuijper
Horst Buerger
Research24 Oct 2005
Laboratory Investigation

Volume: 86, P: 54-61

Search

Filter By:

Search

Quick links