Katagirya et al. conduct differential transcript expression analysis using bulk whole blood RNAseq from HIV-infected children with and without tuberculosis in Uganda, Botswana, and Eswatini. They identify distinct transcripts upregulated in tuberculosis infection by region, but find most transcripts lie within conserved pathways, most notably neutrophil degranulation.
- Eric Katagirya
- Busisiwe Mlotshwa
- Keofentse Mathuba
