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Showing 1–2 of 2 results
Advanced filters: Author: Bing Jhang Li Clear advanced filters

  • A thermoresponsive coacervate enabling the sustained release of micelles and siRNA was developed using an appropriate blend of ABA/AB block copolymers. At room temperature, siRNA-loaded polyion complex (PIC) micelles were dispersed in solution. Upon mild heating ( ≈ 45 °C), they assembled into coacervate microparticles through a reversible phase transition. When maintained at 37 °C, the coacervates continuously and constantly release siRNA and micelles. Biological activities were evaluated using living cells, and cellular uptake and gene knockdown effects were confirmed. This concept highlights a coacervate-based depot platform for siRNA delivery system.

    • Ziwei Ma
    • Hiroshi Kamizawa
    • Akihiro Kishimura
    Research
    Polymer Journal
    P: 1-12

  • Complex coacervates (CCs) are a promising platform for protein encapsulation obtained via simple mixing of some components. Using the novel precoating treatment of living cells, the cellular internalization of CCs was greatly enhanced. Besides, upon using the side-chain modified aniomers for CC fabrication, a wide variety of proteins were successfully encapsulated, which can expand the future biomedical application of CCs.

    • Bing Jhang Li
    • Biplab K C
    • Akihiro Kishimura
    Research
    Polymer Journal
    Volume: 57, P: 911-922