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Showing 1–4 of 4 results
Advanced filters: Author: Brandon Peiffer Clear advanced filters

  • Liver regeneration often fails during chronic liver disease. Here, the authors conduct multiomic profiling of human livers to demonstrate that RNA splicing is dysregulated in alcohol-associated liver disease, interfering with liver regeneration.

    • Ullas V. Chembazhi
    • Sushant Bangru
    • Auinash Kalsotra
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-20

  • Rapamycin and FK506 are macrocycles that contain an FKBP-binding domain and an effector domain responsible for interacting with their respective targets, mTOR and calcineurin. Now, a 45,000-compound macrocycle library has been synthesized by fusing oligopeptides with synthetic FKBP-binding domains. Screening and subsequent optimization yielded a highly potent FKBP-dependent inhibitor of hENT1.

    • Zufeng Guo
    • Sam Y. Hong
    • Jun O. Liu
    Research
    Nature Chemistry
    Volume: 11, P: 254-263

  • Ceramides are signalling molecules that regulate several physiological functions including insulin sensitivity. Here the authors report a selective ceramide synthase 1 inhibitor that counteracts lipid accumulation within the muscle and adiposity by increasing fatty acid oxidation but without affecting insulin sensitivity in mice fed with an obesogenic diet.

    • Nigel Turner
    • Xin Ying Lim
    • Anthony S. Don
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-14