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Showing 1–6 of 6 results
Advanced filters: Author: Breanna Ford Clear advanced filters

  • Estrogen promotes negative energy balance and preserves skeletal physiology. Here the authors show that loss of estrogen signalling after ablating estrogen receptor alpha (ERa) in specific hypothalamic neuronal populations leads to a marked sex-dependent increase in bone mass in female mice.

    • Candice B. Herber
    • William C. Krause
    • Holly A. Ingraham
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-11

  • Timblin et al. demonstrate that LPS or hydroxyoestrogen-induced mitochondrial stress triggers mitohormesis in macrophages, restraining inflammatory gene activation by suppressing oxidative metabolism.

    • Greg A. Timblin
    • Kevin M. Tharp
    • Kaoru Saijo
    Research
    Nature Metabolism
    Volume: 3, P: 618-635

  • A synthetic lethal CRISPR–Cas9 screen identifies ferroptosis suppressor protein 1 as a key ferroptosis-resistance factor, the expression of which correlates with ferroptosis resistance in hundreds of cancer cell lines.

    • Kirill Bersuker
    • Joseph M. Hendricks
    • James A. Olzmann
    Research
    Nature
    Volume: 575, P: 688-692

  • A covalent ligand that targets C277 of ATP6V1A was identified resulting in enhanced v-ATPase activity, inhibition of mTORC1 signaling, increased lysosomal acidification, activation of autophagy and clearance of toxic protein aggregates.

    • Clive Yik-Sham Chung
    • Hijai R. Shin
    • Daniel K. Nomura
    Research
    Nature Chemical Biology
    Volume: 15, P: 776-785

  • In hybrid inviability between Xenopus laevis and Xenopus tropicalis, genomic regions on two X. laevis chromosomes are incompatible with the X. tropicalis cytoplasm and are mis-segregated during mitosis, leading to unbalanced gene expression at the maternal to zygotic transition, followed by cell-autonomous catastrophic embryo death.

    • Romain Gibeaux
    • Rachael Acker
    • Rebecca Heald
    Research
    Nature
    Volume: 553, P: 337-341

  • Development of VHL-recruiting PROTACs that degrade fall armyworm sfBRD3 and sfWDS proteins with high potencies in Sf9 cells and in full larvae, establishing the PROTAC modality as promising for agricultural applications.

    • Gina L. Morgan
    • Hamilton Dickson
    • Denis Fourches
    ResearchOpen Access
    Communications Biology
    Volume: 8, P: 1-12