Nature Search

Controlling nephron precursor differentiation to generate proximal-biased kidney organoids with emerging maturity

Here, the authors develop pluripotent stem cell-derived kidney organoids by mimicking in vivo proximal differentiation, providing a model to study nephron development, injury responses, and a platform for therapeutic discovery.

Jack Schnell
Zhen Miao
Nils O. Lindström
ResearchOpen Access30 Aug 2025
Nature Communications

Volume: 16, P: 1-21
Axial nephron fate switching demonstrates a plastic system tunable on demand

A versatile, human iPSC-derived nephron engineering platform that permits scrutiny of axial patterning mechanisms is critical for identifying the origins of human kidney disease. Here they describe a system in which synchronized human nephron structures are generated from pluripotent stem cells, enabling manipulation of axial segmentation.

MaryAnne A. Achieng
Jack Schnell
Nils O. Lindström
ResearchOpen Access25 Aug 2025
Nature Communications

Volume: 16, P: 1-18
Highly stereoselective synthesis of cyclopentanes bearing four stereocentres by a rhodium carbene-initiated domino sequence

Rhodium catalysts can be used for the generation of cyclopentanes with four stereogenic centres. Here, the authors study the origin of stereoselectivity across multiple steps, ultimately leading to a process displaying extremely high enantio- and diastereoselectivity.

Brendan T Parr
Huw M.L. Davies
Research01 Aug 2014
Nature Communications

Volume: 5, P: 1-12
Genome-wide characteristics of de novo mutations in autism

Ryan KC Yuen
Daniele Merico
Stephen W Scherer
ResearchOpen Access03 Aug 2016
npj Genomic Medicine

Volume: 1, P: 1-10
Generation of patterned kidney organoids that recapitulate the adult kidney collecting duct system from expandable ureteric bud progenitors

Here, the authors model the collecting duct system in kidneys by taking ureteric bud (UB) progenitor cells from both mouse and human primary tissues, as well as from hESC and hiPSC to generate organoids, which can model congenital anomalies of the kidney and urinary tract.

Zipeng Zeng
Biao Huang
Zhongwei Li
ResearchOpen Access15 Jun 2021
Nature Communications

Volume: 12, P: 1-15
Zika Virus Infects Intermediate Progenitor Cells and Post-mitotic Committed Neurons in Human Fetal Brain Tissues

Ming-Yi Lin
Yi-Ling Wang
I-Chueh Huang
ResearchOpen Access01 Nov 2017
Scientific Reports

Volume: 7, P: 1-8
Multicellular tumor-stromal interactions recapitulate aspects of therapeutic response and human oncogenic signaling in a 3D disease model for H3K27M-altered DIPG

Meenakshi Upreti
Astgik Petrosyan
Peter A. Chiarelli
ResearchOpen Access06 Sept 2025
Oncogene

Volume: 44, P: 3694-3712
Sources of personal PM_2.5 exposure during pregnancy in the MADRES cohort

Yan Xu
Karl O’Sharkey
Rima Habre
ResearchOpen Access07 Feb 2024
Journal of Exposure Science & Environmental Epidemiology

Volume: 34, P: 868-877
Robust RNA-Seq of aRNA-amplified single cell material collected by patch clamp

Jae Mun “Hugo” Kim
Adrian Camarena
James A. Knowles
ResearchOpen Access06 Feb 2020
Scientific Reports

Volume: 10, P: 1-9
Glomerular endothelial cell heterogeneity in Alport syndrome

Hasmik Soloyan
Matthew Thornton
Sargis Sedrakyan
ResearchOpen Access10 Jul 2020
Scientific Reports

Volume: 10, P: 1-18
Third trimester cortisol is positively associated with gestational weight gain in pregnant women with class one obesity

Christine H. Naya
Claudia M. Toledo-Corral
Theresa M. Bastain
Research30 Oct 2021
International Journal of Obesity

Volume: 46, P: 366-373

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Controlling nephron precursor differentiation to generate proximal-biased kidney organoids with emerging maturity

Axial nephron fate switching demonstrates a plastic system tunable on demand

Highly stereoselective synthesis of cyclopentanes bearing four stereocentres by a rhodium carbene-initiated domino sequence

Genome-wide characteristics of de novo mutations in autism

Generation of patterned kidney organoids that recapitulate the adult kidney collecting duct system from expandable ureteric bud progenitors

Zika Virus Infects Intermediate Progenitor Cells and Post-mitotic Committed Neurons in Human Fetal Brain Tissues

Multicellular tumor-stromal interactions recapitulate aspects of therapeutic response and human oncogenic signaling in a 3D disease model for H3K27M-altered DIPG

Sources of personal PM_2.5 exposure during pregnancy in the MADRES cohort

Robust RNA-Seq of aRNA-amplified single cell material collected by patch clamp

Glomerular endothelial cell heterogeneity in Alport syndrome

Third trimester cortisol is positively associated with gestational weight gain in pregnant women with class one obesity

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