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Showing 1–3 of 3 results
Advanced filters: Author: Brendon L. Neuen Clear advanced filters

  • In a meta-analysis of 48 randomized trials of chronic kidney disease progression, reduction in the 6-month urinary albumin:creatinine ratio was associated with lower hazard ratios of established kidney disease endpoints, supporting the use of albuminuria change as a surrogate endpoint in clinical trials for chronic kidney disease.

    • Hiddo J. L. Heerspink
    • Willem H. Collier
    • Lesley A. Inker
    Research
    Nature Medicine
    Volume: 32, P: 281-287

  • A meta-analysis of individual-level patient data from 66 clinical studies supports the utility of glomerular filtration rate as a surrogate endpoint in clinical trials for chronic kidney disease, with potential to enable detection of events earlier in the disease course.

    • Lesley A. Inker
    • Willem Collier
    • Mauro Saddelli
    Research
    Nature Medicine
    Volume: 29, P: 1867-1876

  • Several risk tools can accurately predict individual baseline risks of adverse events in people with chronic kidney disease. Here, the authors examine methods of assessing risk and discuss risk-directed patient management, whereby risk is aligned with care delivery to maximize the benefit of available therapeutic strategies.

    • Matthew F. Blum
    • Brendon L. Neuen
    • Morgan E. Grams
    Reviews
    Nature Reviews Nephrology
    Volume: 21, P: 287-298