Nature Search

Pleckstrin domain homology

Richard J. Haslam
Hiroshi B. Koide
Brian A. Hemmings
Research27 May 1993
Nature

Volume: 363, P: 309-310
Substantial increase of protein stability by multiple disulphide bonds

Masazumi Matsumura
Giovanni Signor
Brian W. Matthews
Research16 Nov 1989
Nature

Volume: 342, P: 291-293
IgM N-glycosylation correlates with COVID-19 severity and rate of complement deposition

The role of IgG glycosylation in the immune response has been studied, but less is known about IgM glycosylation. Here the authors characterize glycosylation of SARS-CoV-2 spike specific IgM and show that it correlates with COVID-19 severity and affects complement deposition.

Benjamin S. Haslund-Gourley
Kyra Woloszczuk
Mary Ann Comunale
ResearchOpen Access09 Jan 2024
Nature Communications

Volume: 15, P: 1-19
Oncolytic T-VEC virotherapy plus neoadjuvant chemotherapy in nonmetastatic triple-negative breast cancer: a phase 2 trial

Intratumoral injection of the oncolytic virus talimogene laherparepvec (T-VEC) during weekly paclitaxel before neoadjuvant doxorubicin and cyclophosphamide led to clinical benefit and was well tolerated in patients with stage 2–3 triple-negative breast cancer.

Hatem Soliman
Deanna Hogue
Brian Czerniecki
Research09 Feb 2023
Nature Medicine

Volume: 29, P: 450-457
Frequent truncating mutations of STAG2 in bladder cancer

Todd Waldman and colleagues screened 2,214 tumors for loss of STAG2 expression using immunohistochemistry. They followed up by sequencing STAG2 in 111 urothelial carcinomas and found mutations in 23 of the cases, identifying STAG2 as one of the most commonly mutated genes in bladder cancer.

David A Solomon
Jung-Sik Kim
Todd Waldman
Research13 Oct 2013
Nature Genetics

Volume: 45, P: 1428-1430
Orbital period change of Dimorphos due to the DART kinetic impact

The 33 minute change in the orbital period of Dimorphos after the DART kinetic impact suggests that ejecta contributed a substantial amount of momentum to the asteroid compared with the DART spacecraft alone.

Cristina A. Thomas
Shantanu P. Naidu
Harrison F. Agrusa
ResearchOpen Access01 Mar 2023
Nature

Volume: 616, P: 448-451
The androgen receptor is a therapeutic target in desmoplastic small round cell sarcoma

Androgen receptor can promote tumour progression in desmoplastic small round cell tumour (DSRCT), an aggressive paediatric malignancy that predominantly affects young males. Here, the authors show that DSRCT is an AR-driven malignancy and sensitive to androgen deprivation therapy

Salah-Eddine Lamhamedi-Cherradi
Mayinuer Maitituoheti
Joseph A. Ludwig
ResearchOpen Access01 Jun 2022
Nature Communications

Volume: 13, P: 1-16
Author Correction: Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig

Yulia Rubanova
Ruian Shi
Christian von Mering
Amendments and CorrectionsOpen Access08 Dec 2022
Nature Communications

Volume: 13, P: 1
Author Correction: Combined burden and functional impact tests for cancer driver discovery using DriverPower

Shimin Shuai
Federico Abascal
Christian von Mering
Amendments and CorrectionsOpen Access08 Dec 2022
Nature Communications

Volume: 13, P: 1
A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus

Thomas Vaughan and colleagues report a genome-wide association study of esophageal adenocarcinoma together with its precancerous lesion, Barrett's esophagus. They identified three loci associated with susceptibility to this cancer.

David M Levine
Weronica E Ek
Thomas L Vaughan
Research13 Oct 2013
Nature Genetics

Volume: 45, P: 1487-1493
Author Correction: Divergent mutational processes distinguish hypoxic and normoxic tumours

Vinayak Bhandari
Constance H. Li
Christian von Mering
Amendments and CorrectionsOpen Access08 Dec 2022
Nature Communications

Volume: 13, P: 1
Author Correction: Pathway and network analysis of more than 2500 whole cancer genomes

Matthew A. Reyna
David Haan
Christian von Mering
Amendments and CorrectionsOpen Access08 Dec 2022
Nature Communications

Volume: 13, P: 1
Author Correction: Pan-cancer analysis of whole genomes

Lauri A. Aaltonen
Federico Abascal
Christian von Mering
Amendments and CorrectionsOpen Access25 Jan 2023
Nature

Volume: 614, P: E39
Author Correction: The repertoire of mutational signatures in human cancer

Ludmil B. Alexandrov
Jaegil Kim
Christian von Mering
Amendments and CorrectionsOpen Access25 Jan 2023
Nature

Volume: 614, P: E41
Holding and amplifying electromagnetic waves with temporal non-foster metastructures

Here the authors proposes a mechanism to freeze and amplify electromagnetic waves via time interfaces where the permittivity of the medium is changed from positive to a Non-Foster negative value and then back to positive.

Victor Pacheco-Peña
Yasaman Kiasat
Nader Engheta
ResearchOpen Access20 Mar 2025
Nature Communications

Volume: 16, P: 1-11
Author Correction: Genomic footprints of activated telomere maintenance mechanisms in cancer

Lina Sieverling
Chen Hong
Christian von Mering
Amendments and CorrectionsOpen Access08 Dec 2022
Nature Communications

Volume: 13, P: 1
Author Correction: Integrative pathway enrichment analysis of multivariate omics data

Marta Paczkowska
Jonathan Barenboim
Christian von Mering
Amendments and CorrectionsOpen Access08 Dec 2022
Nature Communications

Volume: 13, P: 1
Author Correction: Inferring structural variant cancer cell fraction

Marek Cmero
Ke Yuan
Christian von Mering
Amendments and CorrectionsOpen Access08 Dec 2022
Nature Communications

Volume: 13, P: 1
Author Correction: The evolutionary history of 2,658 cancers

Moritz Gerstung
Clemency Jolly
Christian von Mering
Amendments and CorrectionsOpen Access25 Jan 2023
Nature

Volume: 614, P: E42
Author Correction: Analyses of non-coding somatic drivers in 2,658 cancer whole genomes

Esther Rheinbay
Morten Muhlig Nielsen
Christian von Mering
Amendments and CorrectionsOpen Access25 Jan 2023
Nature

Volume: 614, P: E40
Author Correction: Patterns of somatic structural variation in human cancer genomes

Yilong Li
Nicola D. Roberts
Christian von Mering
Amendments and CorrectionsOpen Access25 Jan 2023
Nature

Volume: 614, P: E38
Author Correction: A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns

Wei Jiao
Gurnit Atwal
Christian von Mering
Amendments and CorrectionsOpen Access08 Dec 2022
Nature Communications

Volume: 13, P: 1
Detectable clonal mosaicism and its relationship to aging and cancer

Luis Pérez-Jurado, Stephen Chanock and colleagues detect clonal chromosomal abnormalities in peripheral blood or buccal samples from individuals in the general population. They show that the frequency of such events increases with age and is associated with elevated risk of developing subsequent hematological cancers.

Kevin B Jacobs
Meredith Yeager
Stephen J Chanock
Research06 May 2012
Nature Genetics

Volume: 44, P: 651-658
Somatic mutations affect key pathways in lung adenocarcinoma

Sequencing of over 600 genes in a large collection of lung adenocarcinoma samples provides an overview of somatic mutations and signalling pathways altered in cancer genes in this tumour type.

Li Ding
Gad Getz
Richard K. Wilson
Research23 Oct 2008
Nature

Volume: 455, P: 1069-1075
Molecular and biological characterization of a murine ligand for CD40

Richard J. Armitage
William C. Fanslow
Melanie K. Spriggs
Research07 May 1992
Nature

Volume: 357, P: 80-82
Tumor-infiltrating mast cells are associated with resistance to anti-PD-1 therapy

Immune checkpoint therapies (ICT) are promising for treating various cancers, but response rates vary. Here the authors show, in mouse models, that tumor-infiltrating mast cells colocalize with regulatory T cells, coincide with local reduction of MHC-I and CD8 T cells, and is associated with resistance to ICT, which can be reversed by c-kit inhibitor treatment.

Rajasekharan Somasundaram
Thomas Connelly
Meenhard Herlyn
ResearchOpen Access12 Jan 2021
Nature Communications

Volume: 12, P: 1-14
Directional conjugation of monoclonal antibodies to nanoparticles using metal-free click chemistry

This Protocol Extension describes directional conjugation of monoclonal antibodies to nanoparticles via the Fc antibody moiety using metal-free click chemistry, including procedures for synthesis, quality control and evaluation of nanoparticle–antibody conjugates.

Ananthakrishnan S. Jeevarathinam
Mohammed R. Kawelah
Konstantin V. Sokolov
Protocols19 Nov 2025
Nature Protocols

P: 1-28
Quantifying how single dose Ad26.COV2.S vaccine efficacy depends on Spike sequence features

SARS-CoV-2 variants with mutations in spike have emerged during the pandemic. Magaret et al. show that in Latin America, efficacy of the Ad26.COV2.S vaccine against moderate to severe–critical COVID-19 varied by sequence features, antibody escape scores, and neutralization impacting features of the SARS-CoV-2 variant.

Craig A. Magaret
Li Li
Peter B. Gilbert
ResearchOpen Access11 Mar 2024
Nature Communications

Volume: 15, P: 1-22
Allelic effects on KLHL17 expression underlie a pancreatic cancer genome-wide association signal at chr1p36.33

Allele-preferential transcription factor binding can influence pancreatic ductal adenocarcinoma risk loci function. Here, the authors show allele-specific JunB and JunD binding at chr1p36.33 and propose a role for KLHL17 in protein homeostasis by mitigating inflammation.

Katelyn E. Connelly
Katherine Hullin
Laufey T. Amundadottir
ResearchOpen Access30 Apr 2025
Nature Communications

Volume: 16, P: 1-18
Inferring gene expression from cell-free DNA fragmentation profiles

EPIC-seq predicts expression of individual genes from cell-free DNA.

Mohammad Shahrokh Esfahani
Emily G. Hamilton
Ash A. Alizadeh
Research31 Mar 2022
Nature Biotechnology

Volume: 40, P: 585-597
Machine learning models predict long COVID outcomes based on baseline clinical and immunologic factors

Jayavelu, Samaha et al., apply machine learning models on hospital admission data, including antibody titers and viral load, to identify patients at high risk for Long COVID. Low antibody levels, high viral loads, chronic diseases, and female sex are key predictors, supporting early, targeted interventions.

Naresh Doni Jayavelu
Hady Samaha
Matthew C. Altman
ResearchOpen Access03 Jan 2026
Communications Medicine

Volume: 6, P: 1-10
Assessing the contribution of rare variants to complex trait heritability from whole-genome sequence data

Analysis of whole-genome sequences of 25,465 individuals of European ancestry shows that rare variants contribute substantially to the heritability of height and body mass index.

Pierrick Wainschtein
Deepti Jain
Peter M. Visscher
Research07 Mar 2022
Nature Genetics

Volume: 54, P: 263-273
A systematic review of income and education reporting in psychedelic clinical trials

This systematic review analyzes how income and educational attainment are reported in psychedelic-assisted therapy trials. It reveals that only a minority of trials report this information and, when reported, the data have considerable variation in format and ambiguity in details. It also reveals disparities, with participants having higher income and being highly educated overrepresented in trials.

Daniel H. Grossman
Kevin R. Madden
Peter S. Hendricks
Research12 May 2025
Nature Mental Health

Volume: 3, P: 567-574
Principle patterns

Brian Goodwin
Books & Arts06 Dec 1984
Nature

Volume: 312, P: 572-573
Turning on and turning off the sense of smell

Brian Burchell
News & Views07 Mar 1991
Nature

Volume: 350, P: 16-17
Host-microbe multiomic profiling identifies distinct COVID-19 immune dysregulation in solid organ transplant recipients

Solid organ transplant recipients are at increased risk of infectious disease and have unique molecular pathophysiology. Here the authors use host-microbe profiling to assess SARS-CoV-2 infection and immunity in solid organ transplant recipients, showing enhanced viral abundance, impaired clearance, and increased expression of innate immunity genes.

Harry Pickering
Joanna Schaenman
Charles R. Langelier
ResearchOpen Access10 Jan 2025
Nature Communications

Volume: 16, P: 1-16
Author Correction: Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples

Matthew H. Bailey
William U. Meyerson
Christian von Mering
Amendments and CorrectionsOpen Access30 Nov 2020
Nature Communications

Volume: 11, P: 1
A principal target of human immunity to malaria identified by molecular population genetic and immunological analyses

David J. Conway
David R. Cavanagh
Jana S. McBride
Research01 Jun 2000
Nature Medicine

Volume: 6, P: 689-692
Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome

It is unclear how often genetic mosaicism of chromosome X arises. Here, the authors examine women with cancer and cancer-free controls and show that X chromosome mosaicism occurs more frequently than on autosomes, especially on the inactive X chromosome, but is not linked to non-haematologic cancer risk

Mitchell J. Machiela
Weiyin Zhou
Stephen J. Chanock
ResearchOpen Access13 Jun 2016
Nature Communications

Volume: 7, P: 1-9
Lyons et al. reply

S. Kathleen Lyons
Joshua H. Miller
Nicholas J. Gotelli
Research26 Oct 2016
Nature

Volume: 538, P: E3-E4
Correction: Corrigendum: Holocene shifts in the assembly of plant and animal communities implicate human impacts

S. Kathleen Lyons
Kathryn L. Amatangelo
Nicholas J. Gotelli
Amendments and Corrections24 Aug 2016
Nature

Volume: 538, P: 542
Clonal haematopoiesis and risk of chronic liver disease

A study shows that clonal haematopoiesis of indeterminate potential is associated with an increased risk of chronic liver disease specifically through the promotion of liver inflammation and injury.

Waihay J. Wong
Connor Emdin
Pradeep Natarajan
Research12 Apr 2023
Nature

Volume: 616, P: 747-754
The metabolic enzyme hexokinase 2 localizes to the nucleus in AML and normal haematopoietic stem and progenitor cells to maintain stemness

Thomas, Egan et al. report that hexokinase 2 localizes to the nucleus of leukaemic and normal haematopoietic cells to maintain stemness by interacting with nuclear proteins and modulating chromatin accessibility independently of its kinase activity.

Geethu Emily Thomas
Grace Egan
Aaron D. Schimmer
ResearchOpen Access06 Jun 2022
Nature Cell Biology

Volume: 24, P: 872-884
Aptamer-based multiplexed proteomic technology for biomarker discovery

Larry Gold
Deborah Ayers
Dom Zichi
ResearchOpen Access14 Jun 2010
Nature Precedings

P: 1
The landscape of recombination in African Americans

Anjali G. Hinch
Arti Tandon
Simon R. Myers
Research20 Jul 2011
Nature

Volume: 476, P: 170-175
Network news: complete nuclear coverage

Mitosis in vertebrates involves nuclear-envelope breakdown and dispersal. On completion of chromatid segregation, disassembled nuclear-envelope components are reused to form nuclear membranes in the two daughter cells, and the endoplasmic reticulum membrane seems to make a key contribution to this process.

Brian Burke
News & Views01 Oct 2007
Nature Cell Biology

Volume: 9, P: 1123-1124
Genetic effects on gene expression across human tissues

Samples of different body regions from hundreds of human donors are used to study how genetic variation influences gene expression levels in 44 disease-relevant tissues.

François Aguet
Andrew A. Brown
Jingchun Zhu
ResearchOpen Access12 Oct 2017
Nature

Volume: 550, P: 204-213
Genomic analysis defines clonal relationships of ductal carcinoma in situ and recurrent invasive breast cancer

A genomic analysis of ductal carcinoma in situ (DCIS) samples with matched ipsilateral invasive breast cancer recurring later shows that around 18% of tumors were unrelated to the DCIS, and had distinct clonal origins.

Esther H. Lips
Tapsi Kumar
Elinor J. Sawyer
ResearchOpen Access09 Jun 2022
Nature Genetics

Volume: 54, P: 850-860
Developing a fit-for-purpose composite symptom score as a symptom burden endpoint for clinical trials in patients with malignant pleural mesothelioma

Charles S. Cleeland
Karen N. Keating
Tito R. Mendoza
ResearchOpen Access27 Jun 2024
Scientific Reports

Volume: 14, P: 1-10
Whole Genome Association Study of the Plasma Metabolome Identifies Metabolites Linked to Cardiometabolic Disease in Black Individuals

Most studies of the genetics of the metabolome have been done in individuals of European descent. Here, the authors integrate genomics and metabolomics in Black individuals, highlighting the value of whole genome sequencing in diverse populations and linking circulating metabolites to human disease.

Usman A. Tahir
Daniel H. Katz
Robert E. Gerszten
ResearchOpen Access22 Aug 2022
Nature Communications

Volume: 13, P: 1-16

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